Real-time multi-marker measurement of organic compounds in human breath: Towards fingerprinting breath
The prospects for exploiting proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) in medical diagnostics are illustrated through a series of case studies. Measurements of acetone levels in the breath of 68 healthy people are presented along with a longitudinal study of a single person over a period of 1 month. The median acetone concentration across the population was 484 ppbV with a geometric standard deviation (GSD) of 1.6, whilst the average GSD during the single subject longtitudinal study was 1.5. An additional case study is presented which highlights the potential of PTR-ToF-MS in pharmacokinetic studies, based upon the analysis of online breath samples of a person following the consumption of ethanol. PTR-ToF-MS comes into its own when information across a wide mass range is required, particularly when such information must be gathered in a short time during a breathing cycle. To illustrate this property, multicomponent breath analysis in a small study of cystic fibrosis patients is detailed, which provides tentative evidence that online PTR-ToF-MS analysis of tidal breath can distinguish between active infection and non-infected patients.
2013
2019-07-17 21:29:16
1033
Volatile Organic Compounds, breath, proton transfer reaction mass spectrometry, Cystic Fibrosis
r6
Iain R.
White
70
Kerry A
Willis
70
Christopher
Whyte
70
Rebecca
Cordell
70
Robert S
Blake
70
Andrew J
Wardlaw
70
COBISS_ID
3
5423867
DOI
15
10.1088/1752-7155/7/1/017112
NUK URN
18
URN:SI:UNG:REP:WRX9CNKR
RAZ_White_Iain_R_i2013.pdf
1432760
Predstavitvena datoteka
2019-07-22 08:33:39