20.500.12556/RUNG-4880-73a7c638-1534-6200-19ca-7d5637e30274
Effects of alfaxalone or propofol on giant-breed dog neonates viability during elective caesarean sections
Attention must be paid to C-section anesthesia effects on mother and offspring. Alfaxalone induction results in improved puppy viability when compared to propofol. The present study aims to evaluate effects of alfaxalone or propofol induction for elective C-section on newborns, expressed as Apgar score and fetal fluids cortisol concentration. Anesthesia was induced with alfaxalone 3 mg/kg iv in 5 bitches (group A), and propofol 4 mg/kg iv in another 5 (group P), maintained with isoflurane. Amniotic and allantoic fluids were collected to determine cortisol concentration. Apgar score, litter size, newborn gender, birth-weight, maternal age, and parity were recorded. ANOVA, U Mann-Whitney test and ANCOVA assessed the effects of drugs on the Apgar score and fetal fluids cortisol. Thirty-six puppies were randomly selected for the study: 16 from group A and 20 from group P. Only the Apgar score significantly differed between groups. ANCOVA confirmed a significantly higher Apgar score in group A underlining the influence of fetal fluids cortisol concentrations, both resulting in covariates. Present results confirm the effect of anesthesia on the Apgar score of newborns, which is significantly higher for alfaxalone than propofol, suggesting the use of fetal fluids cortisol as a covariate. These findings could be a starting point for further investigations when less viable puppies are detected or expected, such as during an emergency C-section. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Alfaxalone
Apgar score
C-section
Canine neonates
Cortisol
Fetal fluids
true
true
false
Angleški jezik
Ni določen
Delo ni kategorizirano
2019-11-26 03:42:08
2019-11-26 04:12:20
2023-06-09 03:35:18
0000-00-00 00:00:00
2019
0
0
11
9
2019
2019
0000-00-00
PostprintKoncna
Objavljeno
NiDoloceno
0000-00-00
0000-00-00
0000-00-00
5485563
10.3390/ani9110962
URN:SI:UNG:REP:AIYHD2IL
animals-09-00962.pdf
animals-09-00962.pdf
1
CDE4CC4085E9A5836E79A375AD9FF3DE
a7e54512eba3ac7eefd084fde42da5357336c52c4fa9ce1aba5b21ad7c25ee5f
68ae4063-05cf-11ee-9c48-5ef991fed68f
https://repozitorij.ung.si/Dokument.php?lang=slv&id=18915
Univerza v Novi Gorici
0
0
0