Chitosan and their derivatives: Antibiofilm drugs against pathogenic bacteria
Biofilm formed by several pathogenic bacteria results in the development of resistance against antimicrobial compounds. The polymeric materials present in the biofilm architecture hinder the entry of antimicrobial compounds through the surface of bacterial cells which are embedded as well as enclosed beneath the biofilm matrix. Recent and past studies explored the alternative approaches to inhibit the formation of biofilm by different agents isolated from plants, animals, and microbes. Among these agents, chitosan and its derivatives have got more attention due to their properties such as biodegradability, biocompatibility, non-allergenic and non-toxicity. Recent researches have focused on employing chitosan and its derivatives as effective agents to inhibit biofilm formation and attenuate virulence properties by various pathogenic bacteria. Such antibiofilm activity of chitosan and its derivatives can be further enhanced by conjugation with a wide range of bioactive compounds. The present review describes the antibiofilm properties of chitosan and its derivatives against the pathogenic bacteria. This review also summarizes the mechanisms of biofilm inhibition exhibited by these molecules. The knowledge of the antibiofilm activities of chitosan and its derivatives as well as their underlying mechanisms provides essential insights for widening their applications in the future.
2020
2021-01-14 12:19:15
1033
Antibiofilm, Biofilm inhibition, Chitosan, Chitosan derivatives, Pathogenic bacteria
r6
Fazlurrahman
Khan
70
Dong
Pham
70
Sandra
Oloketuyi
70
Panchanathan
Manivasagan
70
Junghwan
Oh
70
Young-Mog
Kim
70
COBISS_ID
3
47102979
DOI
15
10.1016/j.colsurfb.2019.110627
NUK URN
18
URN:SI:UNG:REP:IWJFOPRX
RAZ_Khan_Fazlurrahman_i2020.pdf
4144089
Predstavitvena datoteka
2021-01-14 14:58:38
0
Izvorni URL
2021-01-14 12:19:15