20.500.12556/RUNG-6723
Untargeted molecular analysis of exhaled breath as a diagnostic test for ventilator-associated lower respiratory tract infections (BreathDx)
Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.
ventilator-associated pneumonia
breath analysis
volatile organic compounds
metabolomics
intensive care
hospital acquired infections
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true
false
Angleški jezik
Ni določen
Neznano
2021-09-07 10:29:43
2021-09-07 12:05:21
2023-06-09 03:44:27
0000-00-00 00:00:00
2021
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0
str. 1-3
iss.
Vol.
2021
0000-00-00
NiDoloceno
NiDoloceno
NiDoloceno
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0000-00-00
0000-00-00
75487235
616.2
0040-6376
10.1136/thoraxjnl-2021-217362
URN:SI:UNG:REP:PVOIQNHM
Univerza v Novi Gorici
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