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1.
Hybrid research between Art and Science
2020, radio or television broadcast

Found in: ključnih besedah
Keywords: art thinking, artistic sensibility, born hybrid, collective filtering, video theory, transdisciplinary, organising research, research design, hybrid thinking, curatorship
Published: 08.12.2020; Views: 76; Downloads: 4
URL Fulltext (0,00 KB)

2.
Development and characterization of improved materials for antifouling applications
Urška Lavrenčič Štangar, Iztok Arčon, Tihana Čižmar, 2015, published scientific conference contribution abstract

Found in: ključnih besedah
Summary of found: ...sol-gel method, photocatalysis, hybrid materials, Cu K-edge XANES, photocatalytic activity...
Keywords: sol-gel method, photocatalysis, hybrid materials, Cu K-edge XANES, photocatalytic activity
Published: 15.02.2016; Views: 2215; Downloads: 0
.pdf Fulltext (131,22 KB)

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Auger Highlights
Marko Zavrtanik, Danilo Zavrtanik, Darko Veberič, Samo Stanič, Andrej Filipčič, Antonella Castellina, Gašper Kukec Mezek, Ahmed Saleh, Marta Trini, Serguei Vorobiov, Lili Yang, 2014, published scientific conference contribution

Found in: ključnih besedah
Summary of found: ...Auger Observatory, ultra high energy cosmic rays (UHECR), UHECR hybrid detection technique, UHECR energy spectrum, UHECR mass composition,...
Keywords: Pierre Auger Observatory, ultra high energy cosmic rays (UHECR), UHECR hybrid detection technique, UHECR energy spectrum, UHECR mass composition, UHECR arrival directions
Published: 20.06.2017; Views: 1890; Downloads: 259
.pdf Fulltext (861,47 KB)

6.
New strategy for magnetic gas sensing
Roberta Ciprian, Piero Torelli, Angelo Giglia, B Gobaut, Barbara Ressel, Janez Štupar, Matija Stupar, Antonio Caretta, Giovanni De Ninno, Tommaso Pincelli, Barbara Casarin, Ganesh Adhikari, G Sberviglieri, C Baratto, Marco Malvestuto, 2016, original scientific article

Found in: ključnih besedah
Summary of found: ... hybrid nanostructures, sensor, absorption spectroscopy...
Keywords: hybrid nanostructures, sensor, absorption spectroscopy
Published: 05.02.2018; Views: 1327; Downloads: 0
.pdf Fulltext (2,25 MB)

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8.
Structural and functional determinants of TDP-43 aggregation
Sanja Škaro, 2019, doctoral dissertation

Abstract: TDP-43 (TAR DNA-binding protein) is an hnRNP that was identified as the main component of the brain inclusions characteristically found in patients suffering of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. As an hnRNP protein, TDP-43 fulfills diverse roles in mRNA metabolism, localization and transport. Structurally, TDP-43 is composed of a well conserved N terminal domain (NTD), two RRM domains of which RRM1 is necessary for recognizing and binding to its target, UG rich RNA sequences, and the C-terminal domain (CTD) which is a Glycine rich domain. The CTD also contains a Q/N rich region that plays a key role in protein aggregation and interaction with another hnRNP proteins and polyglutamine repeats. This thesis focus on the structural determinants involved in the different TDP-43 interactions with itself and with other hnRNPs. Both the carboxyl and amino terminal domains are involved in these interactions. We have mapped the regions more relevant for the function of TDP-43 and for the aggregation process characteristic of the pathological pathway leading to neurodegeneration. We have started to further study the N-terminal domain. Previous results in our laboratory using a cellular aggregation model have shown that the N-terminal domain is also necessary for sequestering the endogenous TDP-43 into the aggregates. In particular, the intact NTD, specifically residues 1 to 77, have been shown to be needed to efficiently recruit TDP-43 monomers into these aggregates. We have extended our knowledge of NTD structure and function, by assessing the behavior of a series of proteins in which key structural features (α-helix and β-sheets) were modified and TDP-43 splicing function together with structure via NMR were analyzed. It was found that by disrupting protein secondary structure in the NTD (mutation in α-helix NTD-31V/R-32T/R) the capacity of the aggregates to sequester enough TDP-43 to induce loss of function was lost.In fact, this protein is also unable to recovery TDP-43 functionality when it is disrupted due to sequestration of the endogenous TDP-43 in add back experiments. Disturbing protein stability through substitution of residues in α-helix also affects its ability to form an active conformation. On the other hand, synthesis of hybrid peptides containing certain NTD and CTD segments was performed in order to see if they are capable to bind to the TDP-43 aggregates. However, it has been shown that these synthetic peptides have a greater ability to induce TDP-43 aggregation than to bind to them, probably due to specific functional characteristics of NTD and CTD segments used for their synthesis.The main focus of the thesis was on the C-terminal domain sequences involved in protein-protein interaction, misfolding and aggregation.A comparison of human, mouse, zebrafish, Annelida, flatworms and Drosophila showed a very strong conservation of the NTD and RRMs, but the C terminal regions of human and other TDP-43 orthologues are very different.I have studied Human and Drosophila melanogaster orthologues, because Drosophila orthologue contains different paralogs of TDP-43.Through a series of deletions and mutations it was shown that the shorter paralog of Drosophila TDP-43 (TBPH-RA) is more active than the longer one (TBPH-RC), and that this is due to a combination of two factors: 1. TBPH-RC by itself aggregates more than TBPH-RA, 2. The functionality of TBPH-RC is downregulated by intramolecular interactions in the C terminal domain. Apparently there is a cation-π interaction involving Tryptophan and Arginine in TBPH-RC that has a high relevance to the protein function and is lacking in the TBPH-RA.Overall this data has identified structural features essential for the proper function of TDP-43.In addition, we have also identified sequences that are critical in the pathological aggregation process of TDP-43 that lead to the characteristic brain inclusions in ALS and FTLD and to the loss of functionality
Found in: ključnih besedah
Summary of found: ...conformation. On the other hand, synthesis of hybrid peptides containing certain NTD and CTD segments...
Keywords: TDP-43 structural determinants, hybrid peptides, protein-protein interactions, intramolecular interaction, cation-π interaction, Drosophila orthologues.
Published: 22.07.2019; Views: 907; Downloads: 42
.pdf Fulltext (6,84 MB)

9.
Study of Ultra-High Energy Cosmic Ray composition using Telescope Array’s Middle Drum detector and surface array in hybrid mode
J. P. Lundquist, R.U. Abbasi, 2015, original scientific article

Abstract: Previous measurements of the composition of Ultra-High Energy Cosmic Rays (UHECRs) made by the High Resolution Fly’s Eye (HiRes) and Pierre Auger Observatory (PAO) are seemingly contradictory, but utilize different detection methods, as HiRes was a stereo detector and PAO is a hybrid detector. The five year Telescope Array (TA) Middle Drum hybrid composition measurement is similar in some, but not all, respects in methodology to PAO, and good agreement is evident between data and a light, largely protonic, composition when comparing the measurements to predictions obtained with the QGSJetII-03 and QGSJet-01c models. These models are also in agreement with previous HiRes stereo measurements, confirming the equivalence of the stereo and hybrid methods. The data is incompatible with a pure iron composition, for all models examined, over the available range of energies. The elongation rate and mean values of are in good agreement with Pierre Auger Observatory data. This analysis is presented using two methods: data cuts using simple geometrical variables and a new pattern recognition technique.
Found in: ključnih besedah
Keywords: Ultra-High Energy Cosmic Rays, Cosmic ray composition, Atmospheric fluorescence, Extensive air shower array, Hybrid, Telescope Array
Published: 24.04.2020; Views: 526; Downloads: 0
.pdf Fulltext (3,45 MB)

10.
The hybrid energy spectrum of Telescope Array’s Middle Drum Detector and surface array
J. P. Lundquist, R.U. Abbasi, 2015, original scientific article

Abstract: The Telescope Array experiment studies ultra high energy cosmic rays using a hybrid detector. Fluorescence telescopes measure the longitudinal development of the extensive air shower generated when a primary cosmic ray particle interacts with the atmosphere. Meanwhile, scintillator detectors measure the lateral distribution of secondary shower particles that hit the ground. The Middle Drum (MD) fluorescence telescope station consists of 14 telescopes from the High Resolution Fly’s Eye (HiRes) experiment, providing a direct link back to the HiRes measurements. Using the scintillator detector data in conjunction with the telescope data improves the geometrical reconstruction of the showers significantly, and hence, provides a more accurate reconstruction of the energy of the primary particle. The Middle Drum hybrid spectrum is presented and compared to that measured by the Middle Drum station in monocular mode. Further, the hybrid data establishes a link between the Middle Drum data and the surface array. A comparison between the Middle Drum hybrid energy spectrum and scintillator Surface Detector (SD) spectrum is also shown.
Found in: ključnih besedah
Keywords: Cosmic rays, Energy spectrum, Telescope Array, Hybrid, Ultra high energy
Published: 27.04.2020; Views: 424; Downloads: 0
.pdf Fulltext (3,12 MB)

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