Repozitorij Univerze v Novi Gorici

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22.
The VPS4 component of the ESCRT machinery plays an essential role in HPV infectious entry and capsid disassembly
Lawrence Banks, Colin Crump, Anna Gozdzicka-Jozefiak, Martina Bergant, David Pim, Paola Massimi, Justyna Broniarczyk, 2017, izvirni znanstveni članek

Opis: Human Papillomavirus (HPV) infection involves multiple steps, from cell attachment, through endocytic trafficking towards the trans-Golgi network, and, ultimately, the entry into the nucleus during mitosis. An essential viral protein in infectious entry is the minor capsid protein L2, which engages different components of the endocytic sorting machinery during this process. The ESCRT machinery is one such component that seems to play an important role in the early stages of infection. Here we have analysed the role of specific ESCRT components in HPV infection, and we find an essential role for VPS4. Loss of VPS4 blocks infection with multiple PV types, suggesting an evolutionarily conserved critical step in infectious entry. Intriguingly, both L1 and L2 can interact with VPS4, and appear to be in complex with VPS4 during the early stages of virus infection. By using cell lines stably expressing a dominant-negative mutant form of VPS4, we also show that loss of VPS4 ATPase activity results in a marked delay in capsid uncoating, resulting in a defect in the endocytic transport of incoming PsVs. These results demonstrate that the ESCRT machinery, and in particular VPS4, plays a critical role in the early stages of PV infection.
Najdeno v: osebi
Ključne besede: HPV, ESCRT machinery, infection
Objavljeno: 08.05.2017; Ogledov: 1208; Prenosov: 88
.pdf Polno besedilo (1,10 MB)

23.
Procjena genotoksičnog potencijala uzoraka aerosola iz Tuzle
Maida Šljivić Husejnović, Dalila Imamović, Ermina Cilović, Aida Smajlović, Nahida Srabović, Martina Bergant, 2018, objavljeni znanstveni prispevek na konferenci

Najdeno v: osebi
Ključne besede: aerozagađenje, genotoksičnost, zdravlje ljudi, aerosol, Tuzla
Objavljeno: 30.03.2018; Ogledov: 800; Prenosov: 0
.pdf Polno besedilo (7,20 MB)

24.
How to react to the necessity of a sustainable animal production? The EcoLamb project
Sinan Ogun, Petra Makorič, Martina Bergant, Ario de Marco, Tanja Peric, 2018, objavljeni povzetek znanstvenega prispevka na konferenci

Opis: EcoLamb assesses the sustainability of diverse European sheep production systems focusing on the ecological footprint, animal welfare aspects and nutrition value of lamb meat. The outcomes of these assessments will be used to understand the potential future barriers that limit the innovative capacity and development of the sector and the opportunities that may provide a future market niche against competitive products from other global markets. Farm solutions that incorporate consumer expectations for animal welfare and meat quality will enhance the competitiveness of Europe's lamb meat sector. The project engages trans-national research and industry stakeholders from 6 countries made up of Germany, Italy, Portugal, Slovenia, Spain and Turkey to analyse on 20 case study farms resource-efficient, competitive and low-carbon lamb production models. Direct linkage between animal welfare, meat quality and pharmaceutical use will also be determined using innovative Precision Farming techniques. The project will produce a tool-box of recommendations for productive sheep farm management, supply chain and marketing on how to improve the acceptability of lamb meat by consumers. Thus, the multidisciplinary approach and the multi-actor involvement of the EU sheep sector will assist in re-designing critical aspects to increase society acceptance and the place of lamb meat in future diets and the outcomes of the project will be used by stakeholders to promote changes in farm management, marketing and processing of meat from sheep. Additionally, results will be used by farm consultants, farmer groups and policy officers to re-design consulting approaches and plan new initiatives to make all aspects of the European sheep industry more sustainable.
Najdeno v: osebi
Ključne besede: sustainable, animal production, lamb, sheep, Jezersko-Solčavska, EcoLamb
Objavljeno: 05.09.2018; Ogledov: 507; Prenosov: 0
.pdf Polno besedilo (1,54 MB)

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