1. Novel bispecific nanobody mitigates experimental intestinal inflammation in mice by targeting TNF-▫$\alpha$▫ and IL-23p19 bioactivitiesJiewen Wang, Guangbo Kang, Huiying Lu, Ario De Marco, Haibin Yuan, Zelin Feng, Mengxue Gao, Xiaoli Wang, Huahong Wang, Xiaolan Zhang, 2024, izvirni znanstveni članek Ključne besede: bispecific constructs, nanobodies, intestinal inflammation
Objavljeno v RUNG: 27.03.2024; Ogledov: 263; Prenosov: 3
 Celotno besedilo (12,21 MB)
Gradivo ima več datotek! Več... |
2. Cosmic-ray Heavy Nuclei Spectra Using the ISS-CREAM InstrumentS.C. Kang, Jon Paul Lundquist, 2022, objavljeni znanstveni prispevek na konferenci Opis: Cosmic Ray Energetics And Mass for the International Space Station (ISS-CREAM) was designed to study high-energy cosmic rays up to PeV and recorded data from August 22nd, 2017 to February 12th, 2019 on the ISS. In this analysis, the Silicon Charge Detector (SCD), CALorimeter (CAL), and Top and Bottom Counting Detectors (TCD/BCD) are used. The SCD is composed of four layers and provides the measurement of cosmic-ray charges with a resolution of ∼0.2e. The CAL comprises 20 interleaved tungsten plates and scintillators, measures the incident cosmic-ray particles' energies, and provides a high energy trigger. The TCD/BCDs consist of photodiode arrays and plastic scintillators and provide a low-energy trigger. In this analysis, the SCD top layer is used for charge determination. Here, we present the heavy nuclei analysis using the ISS-CREAM instrument.
Ključne besede: ISS-CREAM, silicon charge detector, calorimeter, direct detection, heavy nuclei, cosmic rays, energy spectrum, composition
Objavljeno v RUNG: 26.09.2023; Ogledov: 577; Prenosov: 5
Celotno besedilo (1,82 MB)
Gradivo ima več datotek! Več... |
3. Affinity maturation of antibody fragments : a review encompassing the development from random approaches to computational rational optimizationJiaqi Liu, Guangbo Kang, Jiewen Wang, Haibin Yuan, Yili Wu, Shuxian Meng, Ping Wang, Miao Zhang, Yuli Wang, Yuanhang Feng, He Huang, Ario De Marco, 2023, pregledni znanstveni članek Ključne besede: deep learning, protein modeling, random mutagenesis, rational mutagenesis
Objavljeno v RUNG: 17.07.2023; Ogledov: 811; Prenosov: 3
Celotno besedilo (2,21 MB) |
4. ŁUKASIEWICZ ANTI FUZZY SUBALGEBRAS OF BCK/BCI-ALGEBRASJeong Gi Kang, Hashem Bordbar, 2025, izvirni znanstveni članek Opis: Abstract. The subalgebra of BCK/BCI-algebra using Łukasiewicz anti fuzzy set
introduced by Jun is studied in this article. The concept of Łukasiewicz anti
fuzzy subalgebra of a BCK/BCI-algebra is introduced, and several properties are
investigated. The relationship between anti fuzzy subalgebra and Łukasiewicz anti
fuzzy subalgebra is given, and the characterization of a Łukasiewicz anti fuzzy subalgebra
is discussed. Conditions are found in which a Lukasiewicz anti fuzzy set is a
Lukasiewicz anti fuzzy subalgebra Finally, conditions under which ⋖-subset, Υ- subset, and anti-subset become subalgebra are explored.
Ključne besede: Anti fuzzy subalgebra, Łukasiewicz anti fuzzy set, Łukasiewicz anti fuzzy subalgebra, ⋖-subset, Υ-subset, anti subset
Objavljeno v RUNG: 20.02.2023; Ogledov: 872; Prenosov: 0
Gradivo ima več datotek! Več... |
5. Design of nanobody-based bispecific constructs by in silico affinity maturation and umbrella sampling simulationsZixuan Bai, Jiewen Wang, Jiaqi Liu, Haibin Yuan, Ping Wang, Miao Zhang, Yuanhang Feng, Xiangtong Cao, Xiangan Cao, Guangbo Kang, Ario De Marco, He Huang, 2023, izvirni znanstveni članek Ključne besede: nanobody rational design, bispecific binders, protein activity inhibition
Objavljeno v RUNG: 03.01.2023; Ogledov: 1116; Prenosov: 3
Celotno besedilo (8,75 MB)
Gradivo ima več datotek! Več... |
6. Research progress and applications of multivalent, multispecific and modified nanobodies for disease treatmentJiewen Wang, Guangbo Kang, Haibin Yuan, Xiaocang Cao, He Huang, Ario De Marco, 2022, izvirni znanstveni članek Ključne besede: nanobody multimers, immunomodulation, intrabodies, imaging, nanobody functionalization
Objavljeno v RUNG: 18.01.2022; Ogledov: 1699; Prenosov: 153
 Povezava na celotno besedilo
Gradivo ima več datotek! Več... |
7. e/p separation study using the ISS-CREAM top and bottom counting detectorsS. C. Kang, Y. Amarea, D. Angelaszek, N. Anthony, G. H. Choi, M. Chung, M. Copley, L. Derome, L. Eraud, C. Falana, Jon Paul Lundquist, 2019, objavljeni znanstveni prispevek na konferenci Opis: Cosmic Ray Energetics And Mass for the International Space Station (ISS-CREAM) is an experiment for studying the origin, acceleration, and propagation mechanisms of high-energy cosmic rays. The ISS-CREAM instrument was launched on the 14th of August 2017 to the ISS aboard the SpaceX-12 Dragon spacecraft. The Top and Bottom Counting Detectors (TCD/BCD) are parts of the ISS-CREAM instrument and designed for studying electron and gamma-ray physics. The TCD/BCD each consist of an array of 20 × 20 photodiodes on a plastic scintillator. The TCD/BCD can separate electrons from protons by using the difference between the shapes of electromagnetic and hadronic showers in the high energy region. The Boosted Decision Tree (BDT) method, which is a deep learning method, is used in this separation study. We will present results of the electron/proton separation study and rejection power in various energy ranges.
Ključne besede: instrumentations, high energy cosmic rays, particle detectors, composition
Objavljeno v RUNG: 08.02.2021; Ogledov: 2225; Prenosov: 0
Gradivo ima več datotek! Več... |
8. On-orbit performance of the top and bottom counting detectors for the ISS-CREAM experiment on the international space stationS.C. Kang, Jon Paul Lundquist, 2019, izvirni znanstveni članek Opis: The Cosmic Ray Energetics And Mass (CREAM) instrument on the International Space Station (ISS) is an experiment to study origin, propagation, acceleration and elemental composition of cosmic rays. The Top Counting Detector (TCD) and Bottom Counting Detector (BCD) are parts of the detector suite of the ISS-CREAM experiment and are designed to separate electrons and protons for studying electron and gamma-ray physics. In addition, the TCD/BCD provide a redundant trigger to that of the calorimeter and a low energy trigger to the ISS-CREAM instrument. After launching, the TCD/BCD trigger was found to be working well. Also, the TCD/BCD have been stable and their hit positions were confirmed to be well matched with other detectors on board. We present the performance and status of the TCD/BCD in flight.
Ključne besede: ISS-CREAM, CREAM, Cosmic rays, TCD/BCD
Objavljeno v RUNG: 27.04.2020; Ogledov: 2610; Prenosov: 111
Celotno besedilo (2,00 MB) |
