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Evaluation of VOC denuder efficiency and positive artefactdue to denuder breakthrough using TCA08
Asta Gregorič, Gašper Lavrič, Martin Rigler, 2019, objavljeni povzetek znanstvenega prispevka na konferenci

Najdeno v: ključnih besedah
Ključne besede: VOC denuder, TCA08, sampling artefact
Objavljeno: 17.07.2019; Ogledov: 795; Prenosov: 0
.pdf Polno besedilo (6,60 MB)

Capturing and Storing Exhaled Breath for Offline Analysis
Stephen J Fowler, Iain R White, 2019, samostojni znanstveni sestavek ali poglavje v monografski publikaciji

Opis: In this chapter we will summarize and discuss methods for the capture and storage of exhaled breath, prior to offline (and indirect online) analysis. We will detail and compare methods currently in use, including their applications, key strengths, and limitations. In synthesizing the best features of each technique, we will propose an ideal standardized breath sampling solution, and give a personal vision on the next steps to be taken in this exciting area of breath research.
Najdeno v: ključnih besedah
Ključne besede: Breath analysis, Breath sampling, Offline analysis, Thermal desorption, Gas chromatography-mass spectrometry
Objavljeno: 22.07.2019; Ogledov: 813; Prenosov: 0
.pdf Polno besedilo (36,24 MB)

Hao Jiang, 2020, diplomsko delo

Opis: For a newly established company, one of the most important issues is to promote its own products and/or services. How to survive among many competitors is a problem, which is worthy of attention. With the popularity of mobile devices, the networks, information and digital society has been established, where global e-commerce has been improved and developed. In this society, for a new company it is highly desirable to use e-commerce promotion methods, which include making a mobile application. However, there is still an open question whether a mobile app can be used as an efficient e-commerce promotion method. In this thesis first an app has been developed for connecting the users and suppliers of musical instruments. All the users are able to share their homemade videos while playing musical instruments and exchange thoughts with all the users. At the same time, all the musical instruments related products can be merchandized between the users and merchant. Then we addressed two issues after the app has been tested: 1. For a startup, is it worth developing a product-related app? 2. In the process of using the app, what kind of attitude is the user taking on the internal product advertisement? An experiment has been set up in which 30 participants were randomly selected. Their behavior has been monitored for one month and the obtained data have been analyzed. The main result of the analysis is that 70% of the participants believe that developing an app brings certain benefit to the company. The remaining 30% of the participants think that they would love to continue to use the app after the experiment. At the same time, they have a certain interest in product advertising in the app.
Najdeno v: ključnih besedah
Ključne besede: Android smartphone app, company promotion, e-commerce, sampling analysis, app development.
Objavljeno: 28.10.2020; Ogledov: 241; Prenosov: 13
.pdf Polno besedilo (918,26 KB)

Alice Avian, 2020, doktorska disertacija

Opis: Human Papillomavirus (HPV) infection is the causative agent for the invasive cervical cancer and its precancerous lesions, furthermore, there are growing evidences of HPV being a relevant factor in other anogenital cancers as well as head and neck cancers. Most sexually active women become infected with HPV at least once in their lifetime, but less than 10% of women becomes persistently infected, and it is precisely the persistent infection that contributes to the development of cervical cancer. The preventive effect of cervical cancer screening largely depends in the high women participation and coverage; indeed, a large number of cervical cancers diagnoses normally arise among under-screened and unscreened women. Increase in the screening coverage is essential to improve the effectiveness of cervical screening programmes. The main purpose of this PhD project was to solve some of the most relevant problems in the cervical cancer screening programmes, as the increase of cost-effectiveness and the amelioration of the screening coverage. My work was focused on the development and validation of the first Ulisse BioMed S.p.A. product, the HPV Selfy™ test, an innovative PCR-based kit for the direct detection and genotyping of 12 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59) and 2 possible/probable high-risk (66 and 68), specifically optimized for the analysis of self-collected vaginal specimens. The core of this innovative test is based on high-resolution melting (HRM) analysis, a recently developed technique for fast, high-throughput post-PCR analysis of variance in nucleic acid sequences, that characterizes the amplicons by studying thermal denaturation of double-stranded DNA. Based on this approach and through the design of different HPV type-specific primer pairs and the development of a specific master mix, unique melting peaks in a single fluorescence channel were obtained, allowing the multiple detection and genotyping of 14 HPV types in a single PCR well. Three different clinical studies have been carried out to validate the assay on the vaginal self-collected samples with truly amazing results regarding the assay’s performance, but also for self-sampling acceptability by women. Moreover, data collected in these studies suggest a future possible use of this test for the hard-to-reach women, as an alternative of the conventional clinician-collected sample, in order to increase the cervical cancer screening coverage.
Najdeno v: ključnih besedah
Povzetek najdenega: ...regarding the assay’s performance, but also for self-sampling acceptability by women. Moreover, data collected in...
Ključne besede: Human Papillomavirus, HPV test, cervical cancer screening, prevention, diagnostic test, High resolution melting, HRM, genotyping, PCR, Self-sampling, clinical validation.
Objavljeno: 17.06.2020; Ogledov: 481; Prenosov: 11
.pdf Polno besedilo (37,88 MB)

Effects of high relative humidity and dry purging on VOCs obtained during breath sampling on common sorbent tubes
Maxim Wilkinson, Iain R White, Roy Goodacre, Tamara Nijsen, Stephen Fowler, 2020, izvirni znanstveni članek

Opis: Offline breath analysis by thermal desorption gas chromatography mass spectrometry (TD-GC-MS) requires the use of sorbent traps to concentrate and store volatile compounds. The selection of which sorbent to use and best practices for managing high relative humidity are important considerations to allow for reproducible, untargeted, biomarker discovery in water saturated breath samples. This work aims to assess three commonly used sorbent materials for their use in breath volatile sampling and determine how the high relative humidity inherent in such samples effects the capture of volatile compounds of interest. TenaxGR, TenaxTA/Carbograph1TD and TenaxTA/Carbograph5TD tubes were selected as they are the most commonly used sorbents in the breath sampling literature. The recovery of 29 compounds in a standard mix loaded using high humidity gas was tested for each sorbent and compared to loading in dry gas. Water retention and dry purge rates were determined for each sorbent for 500 ml and 1000 ml breath collections. Finally, breath samples were collected simultaneously on to each sorbent type using the ReCIVA and analysed by TD-GC-MS. All three sorbents exhibited acceptable reproducibility when loaded with the standard mix in dry gas (RSD < 10%). Loading the standard mix in humid gas led to reduced recovery of compounds based on their chemical properties. Dry purging performance for each sorbent material was assessed and was shown to be 1.14, 1.13 and 0.89 mg H2O min−1 for TenaxGR, TenaxTA/Carbograph1TD and TenaxTA/Carbograph5TD respectively when flushed with 50 ml min−1 of N2. A comparison of breath profiles on different sorbents showed differences in background artefacts (sulfur dioxide, cyclopenten-1-one and 3-nonene) and endogenous breath compounds (2-methyl-furan and furfural). This work demonstrates that high relative humidity during sampling reduces the ability of sorbent tubes to capture volatile compounds and could impact method detection limits during breath sampling. Sufficient water to impair accurate analysis was retained on all tubes. Minimal differences were observed between sorbent materials when used to sample breath, however, suggestions are provided for sorbent selection for future studies.
Najdeno v: ključnih besedah
Ključne besede: VOCs, Breath sampling, ReCIVA
Objavljeno: 27.07.2020; Ogledov: 445; Prenosov: 17
.pdf Polno besedilo (1,18 MB)

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