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1.
Biotechnological applications of nanobody pre-immune libraries
Ario De Marco, predavanje na tuji univerzi

Najdeno v: ključnih besedah
Ključne besede: nanobodies, pre-immune libraries, in vitro selection, biomarkers, recombinant proteins
Objavljeno: 16.05.2017; Ogledov: 1033; Prenosov: 0
.pdf Polno besedilo (331,92 KB)

2.
Nanobodies as biotechnological tools
Ario de Marco, predavanje na tuji univerzi

Najdeno v: ključnih besedah
Ključne besede: nanobodies, pre-immune phage library, recombinant expression, biomarkers, tumors
Objavljeno: 17.05.2017; Ogledov: 1062; Prenosov: 0
.pdf Polno besedilo (290,82 KB)

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4.
Canonical and selective approaches in exosome purification and their implications for diagnostic accuracy
Ario de Marco, Milica Popovic, 2017, pregledni znanstveni članek

Najdeno v: ključnih besedah
Ključne besede: Extracellular vesicles, exosome biomarkers, immune-purification
Objavljeno: 25.09.2017; Ogledov: 1141; Prenosov: 0
.pdf Polno besedilo (1,11 MB)

5.
Nuovi modelli di ricerca: oncologia comparativa per lo studio dei sarcomi
Ario de Marco, vabljeno predavanje na konferenci brez natisa

Najdeno v: ključnih besedah
Ključne besede: Comparative oncology, sarcoma, canine model, immune-reagents
Objavljeno: 10.10.2017; Ogledov: 860; Prenosov: 0
.pdf Polno besedilo (173,81 KB)

6.
Whole-cell biopanning with a synthetic phage display library of nanobodies enabled the recovery of follicle-stimulating hormone receptor inhibitors
Ronan Crepin, Gianluca Veggiani, Selma Djender, Anne Beugnet, Francois Planeix, Christophe Pichon, Sandrine Moutel, Sebastian Amigorena, Franck Pérez, Nicolae Ghinea, Ario De Marco, 2017, izvirni znanstveni članek

Opis: Antibodies are essential reagents that are increasingly used in diagnostics and therapy. Their specificity and capacity to recognize their native antigen are critical characteristics for their in vivo application. Follicle-stimulating hormone receptor is a GPCR protein regulating ovarian follicular maturation and spermatogenesis. Recently, its potentiality as a cancer biomarker has been demonstrated but no antibody suitable for in vivo tumor targeting and treatment has been characterized so far. In this paper we describe the first successful attempt to recover recombinant antibodies against the FSHR and that: i) are directly panned from a pre-immune library using whole cells expressing the target receptor at their surface; ii) show inhibitory activity towards the FSH-induced cAMP accumulation; iii) do not share the same epitope with the natural binder FSH; iv) can be produced inexpensively as mono- or bivalent functional molecules in the bacterial cytoplasm. We expect that the proposed biopanning strategy will be profitable to identify useful functional antibodies for further members of the GPCR class.
Najdeno v: ključnih besedah
Ključne besede: nanobodies, GPCR proteins, FSHR, panning, pre-immune antibody library
Objavljeno: 19.10.2017; Ogledov: 896; Prenosov: 0
.pdf Polno besedilo (982,69 KB)

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