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1.
Comprehensive exploration of wine aroma-related compounds as promoted by alternative vinification procedures in case of Zelen (Vitis vinifera L.) grapes processing
Cristèle Delsart, Urška Vrhovšek, Melita Sternad Lemut, Cesare Lotti, 2016, prispevek na konferenci brez natisa

Najdeno v: ključnih besedah
Povzetek najdenega: ...Zelen (Vitis vinifera L.), targeted metabolomics, wine aroma, sensory evaluation, alternative vinification procedures...
Ključne besede: Zelen (Vitis vinifera L.), targeted metabolomics, wine aroma, sensory evaluation, alternative vinification procedures
Objavljeno: 18.04.2017; Ogledov: 1832; Prenosov: 0
.pdf Polno besedilo (841,25 KB)

2.
Comparison of aroma-related compounds of carbonic maceration and traditional young red winemaking in case of Merlot by means of targeted metabolomic approach
Urška Vrhovšek, Cesare Lotti, Melita Sternad Lemut, 2016, prispevek na konferenci brez natisa

Najdeno v: ključnih besedah
Povzetek najdenega: ...L.), wine aroma, wine sensory evaluation, targeted metabolomics, carbonic maceration...
Ključne besede: Merlot (Vitis vinifera L.), wine aroma, wine sensory evaluation, targeted metabolomics, carbonic maceration
Objavljeno: 18.04.2017; Ogledov: 1868; Prenosov: 0
.pdf Polno besedilo (846,88 KB)

3.
Vitis vinifera root and leaf metabolic composition during fruit maturation: Implications of defoliation
Alain Deloire, Bruno, P. Holzapfel, Celia Barril, Jason, A Smith, katja Šuklje, Baverley, A, Orchard, Gerhard, C. Rossouw, izvirni znanstveni članek

Najdeno v: ključnih besedah
Povzetek najdenega: ...leaf removal, metabolomics, primary metabolsim,vitis vinifera...
Ključne besede: leaf removal, metabolomics, primary metabolsim, vitis vinifera
Objavljeno: 26.07.2017; Ogledov: 2056; Prenosov: 0
.pdf Polno besedilo (1,67 MB)

4.
Study of grapevine early leaf removal sustainability potential by means of targeted metabolomic approach
Melita Sternad Lemut, Paolo Sivilotti, Lorena Butinar, Ajda Lemut, Urška Vrhovšek, 2017, objavljeni povzetek znanstvenega prispevka na konferenci

Najdeno v: ključnih besedah
Povzetek najdenega: ...leaf removal, sustainable viticulture, grape compactness, targeted metabolomics, phenolic compounds...
Ključne besede: Pinot gris, early leaf removal, sustainable viticulture, grape compactness, targeted metabolomics, phenolic compounds
Objavljeno: 21.09.2017; Ogledov: 2127; Prenosov: 0
.pdf Polno besedilo (102,93 KB)

5.
SIGNALING STUDIES IN THE EMERGING KIWIFRUIT PATHOGEN Pseudomonas syringae pv. actinidiae
Sree Gowrinadh Javvadi, 2017, doktorska disertacija

Opis: In the past two decades emerging and re-emerging plant pathogens have caused new threats to the production of several economically important crops, one among them is P. syringae pv. actinidiae (PSA) which causes canker or leaf spot on kiwifruit plants. PSA enters plant through wounds and remains dormant in cortex tissue of the branches, and spreads in the tissue to cause severe symptoms from winter to early spring. The disease can be visualized by brown discoloration of buds, dark brown angular spots surrounded by yellow haloes on leaves, cankers with white to reddish (oxydation) exudate on twigs and trunks, fruit collapse, wilting and eventually plant mortality. Current control methods have their own significance in disease control, however there is considerable lack of clear understanding of PSA pathogenicity. Virulence of plant pathogens often relies on the synchronized/coordinated expression of pathogenicity factors via quorum sensing (QS). Therefore, investigations on QS in PSA may lead to develop novel disease control strategies and reliable methods to curb the disease. It is currently unknown whether PSA produces a QS signal molecule thus the aim of this thesis is to investigate whether PSA possesses a QS system. As genome mining did not reveal the presence of any currently known QS system, this study initially by metabolomics was aimed at identifying potentially low molecular weight secondary metabolite QS molecules produced by PSA. Azelaic acid was discovered to be produced by PSA, this is the first report of azelaic acid production by bacteria. The characterization and possible role of azelaic acid in QS is presented. Since azelaic acid is ubiquitous in nature, in addition to determining its biological role, the catabolism of azelaic acid in bacteria using the efficient degrader Pseudomonas nitroreducens DSM 9128 was also studied.
Najdeno v: ključnih besedah
Povzetek najdenega: ...currently known QS system, this study initially by metabolomics was aimed at identifying potentially low molecular...
Ključne besede: Quorum sensing, Azelaic acid, Metabolomics, Catabolism
Objavljeno: 19.12.2017; Ogledov: 1859; Prenosov: 110
.pdf Polno besedilo (4,41 MB)

6.
Grapes to wine: the nexus between berry ripening, composition and wine style
katja Šuklje, Guillaume Antalick, Campbell Meeks, John W. Blackman, Alain Deloire, Leigh Schmidtke, 2017, objavljeni znanstveni prispevek na konferenci

Najdeno v: ključnih besedah
Povzetek najdenega: ...ACOMDIM, metabolomics, terroir, maturation...
Ključne besede: ACOMDIM, metabolomics, terroir, maturation
Objavljeno: 04.04.2018; Ogledov: 1295; Prenosov: 0
.pdf Polno besedilo (865,76 KB)

7.
Breathomics and its Application for Disease Diagnosis: A Review of Analytical Techniques and Approaches
Enzo A Palombo, Konstantinos A Kouremenos, Ding Y Oh, Iain R White, David J Beale, Avinash V Karpe, Oliver A H Jones, 2018, samostojni znanstveni sestavek ali poglavje v monografski publikaciji

Opis: The application of metabolomics to an ever-greater variety of sample types is a key focus of systems biology research. Recently, there has been a strong focus on applying these approaches toward the rapid analysis of metabolites found in non-invasively acquired samples, such as exhaled breath (also known as ‘breathomics’). The sampling process involved in collecting exhaled breath is nonintrusive and comparatively low-cost. It uses a series of globally approved methods and provides researchers with easy access to the metabolites secreted by the human body. Owing to its accuracy and rapid nature, metabolomic analysis of breath is a rapidly growing field that has proven effective in detecting and diagnosing the early stages of numerous diseases and infections. This review discusses the various collection and analysis methods currently applied in breathomics research. Some of the salient research completed in this field to date is also assessed and discussed in order to provide a basis for possible future scientific directions.
Najdeno v: ključnih besedah
Povzetek najdenega: ...The application of metabolomics to an ever-greater variety of sample types...
Ključne besede: Metabolomics, breath research, VOCs, breathomics
Objavljeno: 22.07.2019; Ogledov: 573; Prenosov: 0
.pdf Polno besedilo (25,96 MB)

8.
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
James Nazroo, Royston Goodacre, Neil Pendleton, Frederick Wu, Iain White, Bram Vanhoutte, Gindo Tampubolon, Alan Marshall, Krisztina Mekli, Zahra Rattray, Tarani Chandola, Caroline Johnson, Drupad Trivedi, Yun Xu, Nicholas Rattray, 2019, izvirni znanstveni članek

Opis: Global ageing poses a substantial economic burden on health and social care costs. Enabling a greater proportion of older people to stay healthy for longer is key to the future sustainability of health, social and economic policy. Frailty and associated decrease in resilience plays a central role in poor health in later life. In this study, we present a population level assessment of the metabolic phenotype associated with frailty. Analysis of serum from 1191 older individuals (aged between 56 and 84 years old) and subsequent longitudinal validation (on 786 subjects) was carried out using liquid and gas chromatography-mass spectrometry metabolomics and stratified across a frailty index designed to quantitatively summarize vulnerability. Through multivariate regression and network modelling and mROC modeling we identified 12 significant metabolites (including three tocotrienols and six carnitines) that differentiate frail and non-frail phenotypes. Our study provides evidence that the dysregulation of carnitine shuttle and vitamin E pathways play a role in the risk of frailty.
Najdeno v: ključnih besedah
Povzetek najdenega: ...out using liquid and gas chromatography-mass spectrometry metabolomics and stratified across a frailty index designed...
Ključne besede: metabolomics, frailty, ageing, LC-MS, serum
Objavljeno: 08.11.2019; Ogledov: 520; Prenosov: 21
.pdf Polno besedilo (2,35 MB)

9.
Facilitating green care improvements in viticulture
Paolo Sivilotti, Tjaša Jug, Urban Česnik, Adesida Rowland, Melita Sternad Lemut, Lorena Butinar, Urška Vrhovšek, 2019, objavljeni znanstveni prispevek na konferenci

Opis: The growing demand of consumers for environment-friendly and safe food products already forced many winemakers to restrict the application of synthetic fungicides to earlier season, trying to reduce the risk of residues being detected in wines. Main risk for infection by B. cinerea, however, occurs later in the season. To support an improvement in whole-season B. cinerea green care, the potential of yeasts as biocontrol agent (PBA) was studied. Selected yeasts were tested for their antifungal activities. Furthermore, a field experiment in Pinot noir and Pinot gris vineyards was designed to study different combinations of optimized canopy microclimate manipulation (CMM) techniques and PBA application. In experimental conditions, PBA's ability to maintain appropriate population density for disease prevention was observed. Grape and wine quality parameters were evaluated. Analytical approach of metabolomics was applied to upgrade the understanding of potentially induced changes in plant metabolism. Based on yeasts testing results, biocontrol yeast P. guilliermondii ZIM 624 was selected and after its field application, we were able to detect its suitable density on grapes until harvest. In case of early defoliation for both varieties smaller grape compactness was confirmed together with lower yield. Among grape basic quality parameters, optimized techniques showed positive effect on sugar content, but unexpectedly, in the treatments with biocontrol yeasts the trends toward higher acidity were noticed in Pinot gris. CMM and PBA introduction indicated some effects on grapevine biosynthetic behaviour but the differences in content of these metabolites compared to control were poorly detected in final wines with exception of mainly some flavonols, stilbenes and flavan-3-ols (and consequently total phenolic content).
Najdeno v: ključnih besedah
Povzetek najdenega: ...quality parameters were evaluated. Analytical approach of metabolomics was applied to upgrade the understanding of...
Ključne besede: sustainable viticulture, Botrytis cinerea, yeasts, biocontrol, canopy microclimate manipulation, metabolomics, grapevine metabolites
Objavljeno: 28.02.2020; Ogledov: 389; Prenosov: 0
.pdf Polno besedilo (7,85 MB)

10.
A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study
Mohammed Ashrafi, Yun Xu, Howbeer Muhamadali, Iain R White, Maxim Wilkinson, Mohamed Baguneid, Roy Goodacre, Ardeshir Bayat, 2020, izvirni znanstveni članek

Opis: Profiling skin microbiome and metabolome has been utilised to gain further insight into wound healing processes. The aims of this multi-part temporal study in 11 volunteers were to analytically profile the dynamic wound tissue and headspace metabolome and sequence microbial communities in acute wound healing at days 0, 7, 14, 21 and 28, and to investigate their relationship to wound healing, using non-invasive quantitative devices. Metabolites were obtained using tissue extraction, sorbent and polydimethylsiloxane patches and analysed using GCMS. PCA of wound tissue metabolome clearly separated time points with 10 metabolites of 346 being involved in separation. Analysis of variance-simultaneous component analysis identified a statistical difference between the wound headspace metabolome, sites (P = 0.0024) and time points (P<0.0001), with 10 out of the 129 metabolites measured involved with this separation between sites and time points. A reciprocal relationship between Staphylococcus spp. and Propionibacterium spp. was observed at day 21 (P<0.05) with a statistical correlation between collagen and Propionibacterium (r = 0.417; P = 0.038) and Staphylococcus (r = -0.434; P = 0.03). Procrustes analysis showed a statistically significant similarity between wound headspace and tissue metabolome with non-invasive wound devices. This exploratory study demonstrates the temporal and dynamic nature of acute wound metabolome and microbiome presenting a novel class of biomarkers that correspond to wound healing, with further confirmatory studies now necessary.
Najdeno v: ključnih besedah
Povzetek najdenega: ... metabolomics, skin, volatile organic compounds, VOCs, wound healing...
Ključne besede: metabolomics, skin, volatile organic compounds, VOCs, wound healing
Objavljeno: 03.03.2020; Ogledov: 409; Prenosov: 0
.pdf Polno besedilo (2,45 MB)

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