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Multicaloric effect during nerve action
Matjaz Valant, 2016, objavljeni povzetek znanstvenega prispevka na konferenci (vabljeno predavanje)

Najdeno v: ključnih besedah
Ključne besede: multikalorični efekt, prenos žičnega signala, solitonski model
Objavljeno: 04.01.2017; Ogledov: 2055; Prenosov: 0
.pdf Polno besedilo (2,48 MB)
Gradivo ima več datotek! Več...

Data model issues in the Cherenkov Telescope Array project
Marko Zavrtanik, Danilo Zavrtanik, Gabrijela Zaharijas, Lili Yang, Serguei Vorobiov, Samo Stanič, Gašper Kukec Mezek, Andrej Filipčič, J.L. Contreras, 2015, objavljeni znanstveni prispevek na konferenci

Najdeno v: ključnih besedah
Ključne besede: Cherenkov Telescope Array (CTA), public observatory, data model
Objavljeno: 02.03.2017; Ogledov: 1425; Prenosov: 137
.pdf Polno besedilo (1,20 MB)

Model vrednotenja primernosti kandidatov za delovna mesta v zdravstvenem domu
Boštjan Milič, 2017, magistrsko delo

Opis: IZVLEČEK V magistrskem delu smo opisali nastali kadrovski odločitveni problem v Zdravstvenem domu Sežana. Obravnavali smo problem vrednotenja primernosti kandidatov za izbrano delovno mesto v zdravstvenem domu. Osredotočili smo se na tri delovna mesta (administratorja, zdravnika stomatologa in zdravnika pediatra) in najprej pridobili podatke o razpisanih delovnih mestih. V razpisih so bili podani kriteriji, s katerimi smo izdelali večparametrski model vrednotenja za vsako delovno mesto posebej. Te modele smo izdelali z računalniškim programom DEXi. Na podlagi tega programa smo vrednotili kandidate za delovna mesta. Izmed 334 prijavljenih kandidatov za delovno mesto administratorja smo z modelom ovrednotili in ugotovili, da je za delovno mesto najprimernejši ekonomist računovodske smeri. Podobno smo izbrali najprimernejša izmed 254 prijavljenih kandidatov za delovno mesto zdravnika stomatologa in med 145 prijavljenimi kandidati za novo delovno mesto zdravnika pediatra. Večparametrski model DEX se je izkazal za odlično alternativo pri izbiri novega kandidata za izbrano delovno mesto. Z uporabo metode šestih klobukov razmišljanja smo potrdili rezultate izbora kandidatov.
Najdeno v: ključnih besedah
Ključne besede: kandidati, delovno mesto, večparametrski model vrednotenja, analiza SWOT, metoda šestih klobukov razmišljanja
Objavljeno: 02.03.2018; Ogledov: 2219; Prenosov: 122
.pdf Polno besedilo (1,24 MB)

Nuovi modelli di ricerca: oncologia comparativa per lo studio dei sarcomi
Ario de Marco, vabljeno predavanje na konferenci brez natisa

Najdeno v: ključnih besedah
Povzetek najdenega: ...Comparative oncology, sarcoma, canine model, immune-reagents...
Ključne besede: Comparative oncology, sarcoma, canine model, immune-reagents
Objavljeno: 10.10.2017; Ogledov: 1408; Prenosov: 0
.pdf Polno besedilo (173,81 KB)

Search for Physics beyond the Standard Model with the CRESST Experiment
2017, magistrsko delo

Opis: In spite of the successes of observational astro- and particle physics and cosmology very much of the universe remains unknown. The Standard Model of particle physics is a theory describing the electromagnetic, weak, and strong nuclear interactions, as well as classifying all the subatomic particles known. But there is overwhelming evidence, that all the known particles, the ordinary (baryonic) matter, the building blocks of planets, stars and ourselves, only make up about 4.9% of the energy content of the universe. The standard model of cosmology (CDM) indicates that the total mass-energy of the universe contains beside the 4.9% ordinary matter two other components: 26.8% dark matter and 68.3% dark energy. The accelerating expansion of the Universe is the result of the effect of the dark energy with its most simple form given by a cosmological constant in Einstein's Equation. Dark matter is an unidentified type of matter that is not accounted for by dark energy and neutrinos and is generally believed to be a non-relativistic, charge neutral and non-baryonic new form of matter. Although dark matter has not been directly observed yet, its existence and properties are inferred from its gravitational effects such as the motions of visible matter, gravitational lensing, its influence on the universe's large-scale structure, and its effects in the cosmic microwave background. Thus the search for Dark Matter is the search for physics beyond the standard model. Although the nature of dark matter is yet unknown, its presence is crucial to understanding the future of the universe. The CRESST experiment is searching for direct evidence in the form of a nuclear recoil induced on a scintillating CaWO4 crystal by a dark matter particle, and is installed and taking data underground at Laboratory Nazionali del Gran Sasso (LNGS) in Italy. While both, dark energy and dark matter, have not been detected directly, a class of dark matter particles that interact only via gravity and the weak force, referred to asWeakly Interacting Massive Particles (WIMPs), has been established as the leading candidate among the dark matter community. For this thesis a special model of dark matter was studied, namely the dark photon. This thesis provides a detailed description of the calculation of the 90% upper limit on the dark photon kinetic mixing based on data from the second phase of the CRESST experiment. The analysis was carried out in a frequentist approach based on the (unbinned) maximum-likelihood method and likelihood ratios. To make a statement about the calculated result and its quality, the used algorithm had to be tested, what was done with Monte Carlo simulations (pseudo data).
Najdeno v: ključnih besedah
Ključne besede: astro physics, particle physics, cosmology, universe, Standard Model of particle physics, standard model of cosmology, matter, ordinary matter, dark matter, dark energy, accelerating expansion of the Universe, non-baryonic, new form of matter, gravitational lensing, cosmic microwave background, search for physics beyond the standard model, CRESST experiment, direct detection, CaWO4 crystal, underground laboratory, Laboratory Nazionali del Gran Sasso, Weakly Interacting Massive Particles, WIMP, dark photon, 90% upper limit, upper limit, kinetic mixing, frequentist approach, unbinned, maximum likelihood
Objavljeno: 13.10.2017; Ogledov: 1651; Prenosov: 0
.pdf Polno besedilo (10,71 MB)

Portrait of light
Marco Pelos Spagno, 2017, diplomsko delo

Opis: This work aims to research the basic structure of lighting in portraits in a controlled light situation. After providing a brief historical introduction to define where modern lighting comes from, I will describe and analyse the tools used to modify the light in a studio and the procedure to follow before a portrait session. I will present a series of images shot in a studio, and I will touch upon most possible basic lighting setups in a portrait session, from most simple ones to some more complex ones, describing the set of lights, the type of modifiers used, and the effects that the light can have on a viewer. My final aim is to build up a collection of light setups that can be helpful to anyone who wants to approach portrait photography and the studio workflow, not aiming to build a manual, but just providing a report on my personal research and study.
Najdeno v: ključnih besedah
Povzetek najdenega: ...portrait, light, studio, study, technique, photography, bw, model, modifiers, controloflight, history, paintings, art, exposure...
Ključne besede: portrait, light, studio, study, technique, photography, bw, model, modifiers, controloflight, history, paintings, art, exposure
Objavljeno: 29.11.2017; Ogledov: 2180; Prenosov: 233
.pdf Polno besedilo (6,53 MB)

Katarzyna Rajkowska, 2018, doktorska disertacija

Opis: The experimental work of this thesis was performed at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in the Human Molecular Genetics Group, under the scientific direction of Prof. Franco Pagani. The project was developed during the academic years 2014-2017. Modified U1 RNAs, also named Exon Specific U1s (ExSpeU1s) represent a novel class of small RNA-based molecules that correct exons splicing defects. To evaluate their therapeutic potential focused on Familial Dysautonomia (FD), a rare autosomal recessive disorder characterized by progressive degeneration of the sensory and autonomic nervous system. More than 99% of patients are homozygous for the T to C transition in position 6 of the IKBKAP intron 20 (c.2204+6T>C). This substitution modifies the exon 20 5’ splice site (5’ss) inducing exon skipping in a tissue-specific manner and reducing the total amount of IKAP protein. The molecular mechanisms underlying the IKBKAP mis-splicing are not completely clear and there are no effective treatments. In this thesis, I investigated the therapeutic potential of ExSpeU1s and the role of cis- and trans-acting factors that regulates IKBKAP splicing. Using a splicing functional assay, I identified ExSpeU1s that bind to intron 20 sequences and rescue the exon 20 skipping defect. Interestingly, their rescue activity was modulated by several splicing factors and requires a critical exonic splicing enhancer element. Transfection experiment showed the involvement of both enhancing (TIA1, PTBP1 and PTB4) and inhibitory (SRSF3, hnRNPA1, FOX and FUS) splicing factors in IKBKAP splicing. To better evaluate the ExSpeU1s therapeutic efficacy, I transduced FD patient’s fibroblasts with a lentiviral vector expressing the most active ExSpeU1. This resulted in a complete rescue of the exon skipping defect and improvement in IKAP protein expression. Most importantly, intraperitoneal delivery of ExSpeU1s by AAV9 into a transgenic mouse model, that recapitulates the tissue-specific mis-splicing seen in FD patients, corrected the aberrant splicing patterns in several tissues increasing the amount of the corresponding IKAP protein. All together, these results identify novel regulatory splicing factors involved in the IKBKAP exon 20 regulation and provide the proof of principle that ExSpeU1s delivered in vivo by AAV vectors represent a novel therapeutic strategy for FD.
Najdeno v: ključnih besedah
Povzetek najdenega: ...ExSpeU1s by AAV9 into a transgenic mouse model, that recapitulates the tissue-specific mis-splicing seen in FD...
Ključne besede: Familial Dysautonomia, IKBKAP, IKAP, splicing, splicing defects, ExSpeU1, U1 snRNA, mouse model, AAV
Objavljeno: 26.03.2018; Ogledov: 1908; Prenosov: 56
.pdf Polno besedilo (13,96 MB)

Hadronic Models of the Fermi Bubbles: Future Perspectives
Lili Yang, Soebur Razzaque, 2018, izvirni znanstveni članek

Najdeno v: ključnih besedah
Povzetek najdenega: ...Fermi bubbles, hadronic model, neutrino, gamma ray...
Ključne besede: Fermi bubbles, hadronic model, neutrino, gamma ray
Objavljeno: 13.04.2018; Ogledov: 1374; Prenosov: 0
.pdf Polno besedilo (605,80 KB)

Dejan Bregar, 2018, doktorska disertacija

Opis: The major causes of Diabetes Mellitus Type 2 (T2DM) are multi-factorial consequences of complex interactions between environmental, social and genetic factors. We investigated the genetic risk factors in Slovene patients with T2DM on a model of microvascular complication – Diabetic Retinopathy (DR). Retrospective case-control study includes a T2DM Slovene population with clinical risk factors for T2DM and DR. Only some of the candidate genes with selected single nucleotid polymorphisms (SNPs) were included: (EDN1 (rs5370, rs3087459, rs1476046), EDNRA (rs5335, rs1801708), EDNRB (rs10507875, rs4885493), NOS3 (rs869109213). By genotyping with either real-time polymerase chain reaction or standard polymerase chain reaction (PCR) we successfully identified the contribution of variable number of tandem repeats rs869109213 in DR progression (Proliferative Diabetic Retinopathy (PDR)) in Slovene patients with T2DM. The joint effect of individual genotypes of rs10507875 in EDNRB and rs869109213 in NOS3 on DR onset (DR) and DR progression (PDR) was demonstrated as well. The joint effect of the two polymorphisms on DR onset (DR) and DR progression (PDR) was greater than the individual effect of each polymorphism separately in the analyzed genetic models. Despite genetic research contributions in DR, linkage studies, and Genome-wide association studies the identification of susceptible loci through candidate gene approaches still remains in its early stages. The frequent approach with an ultimate focus on SNP associations with phenotype is likely to underestimate the roles of genetics in human diseases by disregarding not only the joint effect of multiple loci but the complex interaction network between them. By identifying polymorphisms in genetic disorders in a more systematic way, we will be able to deepen our understanding of the regulatory mechanisms and disease etiology which should lead to a more effective development of mechanism-based therapies as well.
Najdeno v: ključnih besedah
Povzetek najdenega: Slovene patients with T2DM on a model of microvascular complication – Diabetic Retinopathy (DR). Retrospective...
Ključne besede: endothelin 1, EDN1, endothelin receptor A, EDNRA, endothelin receptor B, EDNRB, nitric oxide synthase 3, NOS3, diabetic retinopathy, DR, diabetes mellitus type 2, T2DM, polymorphism, SNP, genetic model
Objavljeno: 07.09.2018; Ogledov: 1171; Prenosov: 86
.pdf Polno besedilo (3,06 MB)

Vrednotenje in izbira merilnih sistemov v avtomobilski industriji
Matevž Ivančič, 2018, magistrsko delo

Opis: V magistrskem delu smo obravnavali vrednotenje in izbiro merilnih sistemov v avtomobilski industriji. Uporaba merilnih sistemov se nanaša na kontrolo premerov lukenj na komutatorjih, ki so eden izmed elementov električnih motorjev. Kontrola premerov lukenj je pomembna faza proizvodnega procesa, saj s tem preprečimo dobavo neustreznih proizvodov. Odločitveni problem se nanaša na izbor najprimernejšega merilnega sistema, kjer izbiramo med štirimi merilnimi sistemi: ročno kontrolo s kontrolnikom Gre/Ne gre, avtomatsko kontrolo s trnom Gre/Ne gre, avtomatsko kontrolo s trnom Gre/Gre s silo in vzporednim merjenjem sile ter avtomatsko kontrolo s kroglico. Vrednotenje in izbor poteka z uporabo večparametrske metode DEX, pri kateri smo za merilni sistem določili ekonomske, tehnološke in kakovostne kriterije ter jih vključili v model za vse štiri merilne sisteme. Po korakih, ki jih določajo metode večparametrskega vrednotenja, smo izdelali celoten model ter z njim ovrednotili in analizirali merilne sisteme. Analize so obsegale analizo ±1, analizo kaj-če ter analizo prednosti in slabosti. Končni rezultat je predlog najprimernejšega merilnega sistema, to je avtomatski merilni sistem s trnom Gre/Gre s silo in vzporednim merjenjem sile.
Najdeno v: ključnih besedah
Povzetek najdenega: kakovostne kriterije ter jih vključili v model za vse štiri merilne sisteme. Po korakih,...
Ključne besede: komutator, premer luknje komutatorja, merilni sistem, odločitveni model, večparametrsko odločanje, metoda DEX, program DEXi
Objavljeno: 03.10.2018; Ogledov: 1665; Prenosov: 94
.pdf Polno besedilo (2,34 MB)

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