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Diversity of bacteria and bacterial products as antibiofilm and antiquorum sensing drugs against pathogenic bacteria
Fazlurrahman Khan, Sandra Oloketuyi, Young-Mog Kim, 2019, pregledni znanstveni članek

Opis: The increase in antibiotic resistance of pathogenic bacteria has led to the development of new therapeutic approaches to inhibit biofilm formation as well as interfere quorum sensing (QS) signaling systems. The QS system is a phenomenon in which pathogenic bacteria produce signaling molecules that are involved in cell to cell communication, production of virulence factors, biofilm maturation, and several other functions. In the natural environment, several non-pathogenic bacteria are present as mixed population along with pathogenic bacteria and they control the behavior of microbial community by producing secondary metabolites. Similarly, non-pathogenic bacteria also take advantages of the QS signaling molecule as a sole carbon source for their growth through catabolism with enzymes. Several enzymes are produced by bacteria which disrupt the biofilm architecture by degrading the composition of extracellular polymeric substances (EPS) such as exopolysaccharide, extracellular- DNA and protein. Thus, the interference of QS system by bacterial metabolic products and enzymatic catalysis, modification of the QS signaling molecules as well as enzymatic disruption of biofilm architecture have been considered as the alternative therapeutic approaches. This review article elaborates on the diversity of different bacterial species with respect to their metabolic products as well as enzymes and their molecular modes of action. The bacterial enzymes and metabolic products will open new and promising perspectives for the development of strategies against the pathogenic bacterial infections.
Najdeno v: ključnih besedah
Povzetek najdenega: ...Bacteria, biofilm, quorum sensing, inhibition, metabolites, pathogen, virulence....
Ključne besede: Bacteria, biofilm, quorum sensing, inhibition, metabolites, pathogen, virulence.
Objavljeno: 18.01.2021; Ogledov: 827; Prenosov: 0
.pdf Polno besedilo (2,17 MB)

Strategies of biofilm inhibition and virulence attenuation of food borne pathogen-Escherichia coli O157:H7
Sandra Oloketuyi, Fazlurrahman Khan, 2017, pregledni znanstveni članek

Opis: Enterohemorrhagic Escherichia coli (E. coli) O157:H7, a gram-negative bacteria identified as a foodborne pathogen causing severe disease is of great concern worldwide. The pathogenicity of E. coli O157:H7 is due to the presence of some virulence factors and its ability to form biofilm which resist antimicrobial compounds, withstand harsh environmental condition and protects from the host immune responses. Formation of biofilm is a multistep process such as adhesion, cellular aggregation and productions of extracellular matrix in which colonies are embedded. There are high numbers of research in the discovery of natural and synthetic compounds which can attenuate the E. coli O157:H7 biofilm formation as well as suppress virulence-related genes. The present review article focuses on the steps involved in E. coli O157:H7 biofilm formation, factors associated with virulence and attenuation.
Najdeno v: ključnih besedah
Ključne besede: Escherichia coli, pathogen, virulence
Objavljeno: 14.01.2021; Ogledov: 725; Prenosov: 0
.pdf Polno besedilo (886,73 KB)

Inhibition strategies of Listeria monocytogenes biofilms- Current knowledge and future outlooks.
Sandra Oloketuyi, Fazlurrahman Khanna, 2017, pregledni znanstveni članek

Opis: There is an increasing trend in the food industry on the Listeria monocytogenes biofilm formation and inhibition. This is attributed to its easy survival on contact surfaces, resistance to disinfectants or antibiotics and growth under the stringent condition used for food processing and preservation thereby leading to food contamination products by direct or indirect exposure. Though, there is a lack of conclusive evidences about the mechanism of biofilm formation, in this review, the concept of biofilm formation and various chemical, physical, and green technology approaches to prevent or control the biofilm formed is discussed. State-of-the-art approaches ranging from the application of natural to synthetic molecules with high effectiveness and non-toxicity targeted at the different steps of biofilm formation could positively influence the biofilm inhibition in the future.
Najdeno v: ključnih besedah
Ključne besede: Listeria monocytogenes, biofilm, food industry, inhibition, pathogen
Objavljeno: 14.01.2021; Ogledov: 820; Prenosov: 0
.pdf Polno besedilo (697,40 KB)
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