Repozitorij Univerze v Novi Gorici

Iskanje po repozitoriju
A+ | A- | Pomoč | SLO | ENG

Iskalni niz: išči po
išči po
išči po
išči po
* po starem in bolonjskem študiju

Opcije:
  Ponastavi


1 - 5 / 5
Na začetekNa prejšnjo stran1Na naslednjo stranNa konec
1.
Selection criteria and engineering of nanobodies for oncological applications
Ario de Marco, predavanje na tuji univerzi

Opis: Lecture relative to the biotechnological features of nanobodies
Najdeno v: ključnih besedah
Povzetek najdenega: ...nanobodies, phage display, antibody engineering, panning...
Ključne besede: nanobodies, phage display, antibody engineering, panning
Objavljeno: 14.07.2016; Ogledov: 1242; Prenosov: 0
.pdf Polno besedilo (22,12 KB)

2.
NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies
Jean-Christophe Rain, Laetitia Ligat, Ario de Marco, Emilie Lemesre, Laura Keller, Virginie Bernard, Nicolas Bery, Sandrine Moutel, Gilles Fevre, Aurelien Olichon, Franck Perez, 2016, izvirni znanstveni članek

Opis: In vitro selection of antibodies allows to obtain highly functional binders, rapidly and at lower cost. Here, we describe the first fully synthetic phage display library of humanized llama single domain antibody (NaLi-H1: Nanobody Library Humanized 1). Based on a humanized synthetic single domain antibody (hs2dAb) scaffold optimized for intracellular stability, the highly diverse library provides high affinity binders without animal immunization. NaLi-H1 was screened following several selection schemes against various targets (Fluorescent proteins, actin, tubulin, p53, HP1). Conformation antibodies against active RHO GTPase were also obtained. Selected hs2dAb were used in various immunoassays and were often found to be functional intrabodies, enabling tracking or inhibition of endogenous targets. Functionalization of intrabodies allowed specific protein knockdown in living cells. Finally, direct selection against the surface of tumor cells produced hs2dAb directed against tumor-specific antigens further highlighting the potential use of this library for therapeutic applications.
Najdeno v: ključnih besedah
Povzetek najdenega: ...Here, we describe the first fully synthetic phage display library of humanized llama single domain antibody...
Ključne besede: nanobodies, synthetic phage display library, in vitro panning
Objavljeno: 17.08.2016; Ogledov: 1608; Prenosov: 132
.pdf Polno besedilo (4,32 MB)

3.
Nanobodies for research & clinical applications
Ario de Marco, predavanje na tuji univerzi

Opis: Nanobody technology evolved rapidly in the last years and now is available for applications in basic sciences as well as in diagnostics and therapy
Najdeno v: ključnih besedah
Povzetek najdenega: ...nanobodies, antibody functionalization, phage display panning, recombinant antibody production...
Ključne besede: nanobodies, antibody functionalization, phage display panning, recombinant antibody production
Objavljeno: 11.10.2016; Ogledov: 1470; Prenosov: 0
.pdf Polno besedilo (773,47 KB)

4.
Advantages offered by the nanobody format when highly-specific reagents are needed for biotechnological applications
Ario de Marco, predavanje na tuji univerzi

Najdeno v: ključnih besedah
Povzetek najdenega: ...Antibody panning, pre-immune phage display library, nanobody, tumor marker, bacterial display...
Ključne besede: Antibody panning, pre-immune phage display library, nanobody, tumor marker, bacterial display
Objavljeno: 18.05.2017; Ogledov: 1006; Prenosov: 0
.pdf Polno besedilo (2,23 MB)

5.
Nanobodies: How to Exploit Pre-Immune Libraries and Recombinant Antibody Fragments
Ario De Marco, vabljeno predavanje na konferenci brez natisa

Najdeno v: ključnih besedah
Povzetek najdenega: ...nanobodies, in vitro panning, phage display...
Ključne besede: nanobodies, in vitro panning, phage display
Objavljeno: 23.08.2019; Ogledov: 199; Prenosov: 0
.pdf Polno besedilo (188,41 KB)

Iskanje izvedeno v 0 sek.
Na vrh