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1.
Vpliv fenilbutirata na aktivnost z AMP aktivirane protein-kinaze v sesalskih celicah
Tina Kocjan, 2013, diplomsko delo

Najdeno v: ključnih besedah
Ključne besede: fenilbutirat, protein-kinaza, celične kulture, imunodetekcija, sesalne celice, diplomske naloge
Objavljeno: 15.10.2013; Ogledov: 2527; Prenosov: 237
URL Polno besedilo (0,00 KB)
Gradivo ima več datotek! Več...

2.
In vitro selection of DNA aptamers for proteins immobilized on magnetic beads and monitoring of ssDNA pool evolution
Nina Mencin, 2015, doktorska disertacija

Najdeno v: ključnih besedah
Povzetek najdenega: ...aptamer, SELEX, protocol optimization, pool evolution monitoring, protein Cdc45...
Ključne besede: aptamer, SELEX, protocol optimization, pool evolution monitoring, protein Cdc45
Objavljeno: 01.04.2015; Ogledov: 2610; Prenosov: 218
.pdf Polno besedilo (2,71 MB)

3.
In vitro selection of DNA aptamers for proteins immobilized on magnetic beads and monitoring of ssDNA pool evolution
Nina Mencin, 2015, doktorska disertacija

Najdeno v: ključnih besedah
Povzetek najdenega: ...aptameri, SELEX, optimizacija protokola, protein Cdc45, disertacije, ...
Ključne besede: aptameri, SELEX, optimizacija protokola, protein Cdc45, disertacije
Objavljeno: 10.07.2015; Ogledov: 2045; Prenosov: 65
URL Polno besedilo (0,00 KB)

4.
Computational design of customised nanobodies for biotechnological applications
Sara Fortuna, Ario de Marco, Miguel Soler, 2016, prispevek na konferenci brez natisa

Opis: In silico modeling to improve the biophysical characteristics of recombinant single-domain antibodies
Najdeno v: ključnih besedah
Povzetek najdenega: ...nanobodies, modeling, protein stability, antibody humanization, molecular dynamics...
Ključne besede: nanobodies, modeling, protein stability, antibody humanization, molecular dynamics
Objavljeno: 26.04.2016; Ogledov: 1382; Prenosov: 0
.pdf Polno besedilo (2,42 MB)

5.
Entropic cost of folding and phase diagrams of polypeptides: Why are IDPs unfolded at room temperature?
Artem Badasyan, predavanje na tuji univerzi

Opis: In spin models, that are applied to describe the conformational transitions in polymers, the number of spin orientations, that correspond to the disordered conformation, can be estimated using fundamental definitions of Statistical Physics. For instance, when considering alpha-helix to coil transition in polypeptides, the role of generalized coordinates is played by pairs of torsional angle, and the repeating unit populates different regions of that 2D contour map, depending on conformation. By scanning over all possible torsional angles, that do not violate the obvious limitations due to the excluded volume, the so-called Ramachandran map can be plotted, which is actually the phase space visualization for the helix-coil transition problem. The region of phase space, corresponding to the ordered, helical conformations, is much more limited, than the one, corresponding to all other (allowed) conformations. We can calculate the areas of these regions as Γhelix and Γcoil , and construct the ratio Q = Γcoil . Naturally, it can be interpreted as log(Q) = Scoil − Shelix = ΔS, the entropic cost of helix with respect to coil. To illustrate the importance of the entropic price of ordered conformation we report our recent results, that allowed to explain the peculiarity of phase diagrams of Intrinsically Disordered Proteins (IDP) out of larger Q-values, as compared to globular counterparts. In particular, it has been shown, that due to larger Q, the phase diagram of IDP is shifted towards higher temperatures.
Najdeno v: ključnih besedah
Povzetek najdenega: ...IDP, protein folding, phase diagram...
Ključne besede: IDP, protein folding, phase diagram
Objavljeno: 23.06.2016; Ogledov: 1558; Prenosov: 0
.pdf Polno besedilo (2,96 MB)
Gradivo ima več datotek! Več...

6.
Human papillomavirus infection requires the TSG101 component of the ESCRT machinery
Martina Bergant Marušič, Justyna Broniarczyk, Anna Gozdzicka-Jozefiak, Lawrence Banks, 2014, izvirni znanstveni članek

Najdeno v: ključnih besedah
Povzetek najdenega: ...humani virusi papiloma, infekcije, protein L2, TSG101, ...
Ključne besede: humani virusi papiloma, infekcije, protein L2, TSG101
Objavljeno: 16.06.2016; Ogledov: 1655; Prenosov: 4
URL Polno besedilo (0,00 KB)

7.
An intrabody specific for the nucleophosmin carboxy-terminal mutant and fused to a nuclear localization sequence binds its antigen but fails to relocate it in the nucleus
Ario De Marco, Chiara Martinelli, Emanuela Colombo, Daniele Piccini, Cristina Sironi, Pier Giuseppe Pelicci, 2014, izvirni znanstveni članek

Najdeno v: ključnih besedah
Povzetek najdenega: ...intrabody, leukemia, protein shuttling, recombinant fusion protein, single-chain antibody, ...
Ključne besede: intrabody, leukemia, protein shuttling, recombinant fusion protein, single-chain antibody
Objavljeno: 16.06.2016; Ogledov: 1233; Prenosov: 8
URL Polno besedilo (0,00 KB)

8.
Recent contributions in the field of the recombinant expression of disulfide bonded proteins in bacteria
Ario De Marco, 2012, kratki znanstveni prispevek

Najdeno v: ključnih besedah
Povzetek najdenega: ...recombinant protein expression, disulfide, bonds, redox conditions, ...
Ključne besede: recombinant protein expression, disulfide, bonds, redox conditions
Objavljeno: 16.06.2016; Ogledov: 1184; Prenosov: 48
URL Polno besedilo (0,00 KB)

9.
The Trip Adviser guide to the protein science world
Ario De Marco, Mario Lebendiker, Tsafi Danieli, 2014, kratki znanstveni prispevek

Najdeno v: ključnih besedah
Ključne besede: protein quality, protein production, biophysics
Objavljeno: 16.06.2016; Ogledov: 1279; Prenosov: 50
URL Polno besedilo (0,00 KB)

10.
Distance-based configurational entropy of proteins from molecular dynamics simulations
Federico Fogolari, Alessandra Corazza, Sara Fortuna, Miguel Angel Soler, Bryan VanSchouwen, Giorgia Brancolini, Stefano Corni, Giuseppe Melacini, Gennaro Esposito, 2015, izvirni znanstveni članek

Opis: Estimation of configurational entropy from molecular dynamics trajectories is a difficult task which is often performed using quasi-harmonic or histogram analysis. An entirely different approach, proposed recently, estimates local density distribution around each conformational sample by measuring the distance from its nearest neighbors. In this work we show this theoretically well grounded the method can be easily applied to estimate the entropy from conformational sampling. We consider a set of systems that are representative of important biomolecular processes. In particular: reference entropies for amino acids in unfolded proteins are obtained from a database of residues not participating in secondary structure elements; the conformational entropy of folding of β2-microglobulin is computed from molecular dynamics simulations using reference entropies for the unfolded state; backbone conformational entropy is computed from molecular dynamics simulations of four different states of the EPAC protein and compared with order parameters (often used as a measure of entropy); the conformational and rototranslational entropy of binding is computed from simulations of 20 tripeptides bound to the peptide binding protein OppA and of β2-microglobulin bound to a citrate coated gold surface. This work shows the potential of the method in the most representative biological processes involving proteins, and provides a valuable alternative, principally in the shown cases, where other approaches are problematic.
Najdeno v: ključnih besedah
Povzetek najdenega: ...reference entropies for amino acids in unfolded proteins are obtained from a database of residues...
Ključne besede: entropy, protein, molecular dynamics, simulations, MD
Objavljeno: 12.10.2016; Ogledov: 1233; Prenosov: 118
.pdf Polno besedilo (2,40 MB)

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