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1.
Role of calcitonin gene-related peptide and brain natriuretic peptide to modulate the excitability state of trigeminal neurons
Andrea Nistri, Elsa Fabbretti, Sandra Vilotti, 2015, pregledni znanstveni članek

Najdeno v: ključnih besedah
Povzetek najdenega: ...trigeminal ganglion, headache, pain, sensory neurons, P2X3, TRPV1, ...
Ključne besede: trigeminal ganglion, headache, pain, sensory neurons, P2X3, TRPV1
Objavljeno: 17.05.2016; Ogledov: 1570; Prenosov: 3
URL Polno besedilo (0,00 KB)

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Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization
Elsa Fabbretti, Andrea Nistri, Sandra Vilotti, Anna Marchenkova, 2015, izvirni znanstveni članek

Najdeno v: ključnih besedah
Povzetek najdenega: ...pain, sensory neurons, natriuretic peptide, signaling, ...
Ključne besede: pain, sensory neurons, natriuretic peptide, signaling
Objavljeno: 17.05.2016; Ogledov: 1583; Prenosov: 36
URL Polno besedilo (0,00 KB)

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P2X receptors, sensory neurons and pain
Elsa Fabbretti, Tanja Bele, 2015, pregledni znanstveni članek

Najdeno v: ključnih besedah
Ključne besede: synapse, pain receptors, ATP, sensory neurons, MAGUK
Objavljeno: 16.06.2016; Ogledov: 1646; Prenosov: 47
URL Polno besedilo (0,00 KB)

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The scaffold protein calcium/calmodulin-dependent serine protein kinase controls ATP release in sensory ganglia upon P2X3 receptor activation and is part of an ATP keeper complex.
Elsa Fabbretti, Tanja Bele, 2016, izvirni znanstveni članek

Opis: P2X3 receptors, gated by extracellular ATP, are expressed by sensory neurons and are involved in peripheral nociception and pain sensitization. The ability of P2X3 receptors to transduce extracellular stimuli into neuronal signals critically depends on the dynamic molecular partnership with the calcium/calmodulin-dependent serine protein kinase (CASK). The present work used trigeminal sensory neurons to study the impact that activation of P2X3 receptors (evoked by the agonist α,β-meATP) has on the release of endogenous ATP and how CASK modulates this phenomenon. P2X3 receptor function was followed by ATP efflux via Pannexin1 (Panx1) hemichannels, a mechanism that was blocked by the P2X3 receptor antagonist A-317491, and by P2X3 silencing. ATP efflux was enhanced by nerve growth factor, a treatment known to potentiate P2X3 receptor function. Basal ATP efflux was not controlled by CASK, and carbenoxolone or Pannexin silencing reduced ATP release upon P2X3 receptor function. CASK-controlled ATP efflux followed P2X3 receptor activity, but not depolarization-evoked ATP release. Molecular biology experiments showed that CASK was essential for the transactivation of Panx1 upon P2X3 receptor activation. These data suggest that P2X3 receptor function controls a new type of feed-forward purinergic signaling on surrounding cells, with consequences at peripheral and spinal cord level. Thus, P2X3 receptor-mediated ATP efflux may be considered for the future development of pharmacological strategies aimed at containing neuronal sensitization. P2X3 receptors are involved in sensory transduction and associate to CASK. We have studied in primary sensory neurons the molecular mechanisms downstream P2X3 receptor activation, namely ATP release and partnership with CASK or Panx1. Our data suggest that CASK and P2X3 receptors are part of an ATP keeper complex, with important feed-forward consequences at peripheral and central level.
Najdeno v: ključnih besedah
Ključne besede: DRG, hemichannels, pain, purinergic signaling, sensory neurons
Objavljeno: 19.01.2017; Ogledov: 1402; Prenosov: 0
.pdf Polno besedilo (801,97 KB)

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Comprehensive exploration of wine aroma-related compounds as promoted by alternative vinification procedures in case of Zelen (Vitis vinifera L.) grapes processing
Cristèle Delsart, Urška Vrhovšek, Melita Sternad Lemut, Cesare Lotti, 2016, prispevek na konferenci brez natisa

Najdeno v: ključnih besedah
Povzetek najdenega: ...(Vitis vinifera L.), targeted metabolomics, wine aroma, sensory evaluation, alternative vinification procedures...
Ključne besede: Zelen (Vitis vinifera L.), targeted metabolomics, wine aroma, sensory evaluation, alternative vinification procedures
Objavljeno: 18.04.2017; Ogledov: 1357; Prenosov: 0
.pdf Polno besedilo (841,25 KB)

7.
Comparison of aroma-related compounds of carbonic maceration and traditional young red winemaking in case of Merlot by means of targeted metabolomic approach
Urška Vrhovšek, Cesare Lotti, Melita Sternad Lemut, 2016, prispevek na konferenci brez natisa

Najdeno v: ključnih besedah
Povzetek najdenega: ...Merlot (Vitis vinifera L.), wine aroma, wine sensory evaluation, targeted metabolomics, carbonic maceration...
Ključne besede: Merlot (Vitis vinifera L.), wine aroma, wine sensory evaluation, targeted metabolomics, carbonic maceration
Objavljeno: 18.04.2017; Ogledov: 1376; Prenosov: 0
.pdf Polno besedilo (846,88 KB)

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