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Heart rate variability and nonlinear dynamic analysis in patients with stress-induced cardiomyopathy
Antonija Krstačić, Paolo Castiglioni, Dragan Gamberger, Gianfranco Parati, Goran Krstačić, Robert Steiner, 2012, izvirni znanstveni članek

Opis: Complexity-based analyses may quantify abnormalities in heart rate variability (HRV). The aim of this study was to investigate the clinical and prognostic significances of dynamic HRV changes in patients with stress-induced cardiomyopathy Takotsubo syndrome (TS) by means of linear and nonlinear analysis. Patients with TS were included in study after complete noninvasive and invasive cardiovascular diagnostic evaluation and compared to an age and gender matched control group of healthy subjects. Series of R–R interval and of ST–T interval values were obtained from 24-h ECG recordings after digital sampling. HRV analysis was performed by ‘range rescaled analysis’ to determine the Hurst exponent, by detrended fluctuation analysis to quantify fractal longrange correlation properties, and by approximate entropy to assess time-series predictability. Short- and long-term fractal-scaling exponents were significantly higher in patients with TS in acute phases, opposite to lower approximate entropy and Hurst exponent, but all variables normalized in a few weeks. Dynamic HRV analysis allows assessing changes in complexity features of HRV in TS patients during the acute stage, and to monitor recovery after treatment, thus complementing traditional ECG and clinically analysis.
Najdeno v: ključnih besedah
Ključne besede: Heart rate variability, Nonlinear dynamics, Chaos theory, Stress-induced cardiomyopathy, Takotsubo syndrome
Objavljeno: 13.07.2017; Ogledov: 1679; Prenosov: 0
.pdf Polno besedilo (742,92 KB)

Confronting two biomolecular techniques to detect NRF2 gene polymorphism biomarkers
Pieranna Chiarella, Renata Sisto, Ario de Marco, 2018, izvirni znanstveni članek

Najdeno v: ključnih besedah
Povzetek najdenega: ...biomarkers, gene polymorphism, NRF2, oxidative stress, PCR, RFLP...
Ključne besede: biomarkers, gene polymorphism, NRF2, oxidative stress, PCR, RFLP
Objavljeno: 11.12.2018; Ogledov: 707; Prenosov: 67
URL Polno besedilo (0,00 KB)
Gradivo ima več datotek! Več...

Comparison of ex vivo and in vitro human fibroblast ageing models.
Pascal Sommer, Roberta Tiozzo, Giulia Annovi, Federica Boraldi, Daniela Quaglino, 2010, izvirni znanstveni članek

Opis: Several studies have analyzed modulation of gene expression during physiological ageing with interesting, but often contradictory results, depending on the model used. In the present report we compare age-related metabolic and synthetic parameters in human dermal fibroblasts (HDF) isolated from young and old subjects (ex vivo ageing model) and cultured from early up to late cumulative population doublings (CPD) (in vitro ageing model) in order to distinguish changes induced in vivo by the aged environment and maintained in vitro, from those associated with cell senescence and progressive CPD. Results demonstrate that fibroblasts from aged donors, already at early CPD, exhibit an impaired redox balance, highlighting the importance of this parameter during ageing, even in the presence of standard environmental conditions, which are considered optimal for cell growth. By contrast, several proteins, as those related to heat shock response, or involved in endoplasmic reticulum and membrane trafficking, appeared differentially expressed only during in vitro ageing, suggesting that, at high CPD, the whole cell machinery becomes permanently altered. Finally, given the importance of the elastic component for a long-lasting connective tissue structural and functional compliance, this study focuses also on elastin and fibulin-5 synthesis and deposition, demonstrating a close relationship between fibulin-5 and ageing.
Najdeno v: ključnih besedah
Povzetek najdenega: ...Ageing Fibroblast Connective tissue Oxidative stress Protein expression Elastin...
Ključne besede: Ageing Fibroblast Connective tissue Oxidative stress Protein expression Elastin
Objavljeno: 23.08.2019; Ogledov: 606; Prenosov: 0
.pdf Polno besedilo (830,45 KB)

The excess of phosphorus in soil reduces physiological performances over time but enhances prompt recovery of salt-stressed Arundo donax plants
Cristina Gonnelli, Roberto Tognetti, Mauro Centritto, Francesco Loreto, Cecilia Brunetti, Federico Brilli, Sara Pignattelli, Susanna Pollastri, Claudia Cocozza, 2020, izvirni znanstveni članek

Opis: Arundo donax L. is an invasive grass species with high tolerance to a wide range of environmental stresses. The response of potted A. donax plants to soil stress characterized by prolonged exposure (43 days) to salinity (+Na), to high concentration of phosphorus (+P), and to the combination of high Na and P (+NaP) followed by 14 days of recovery under optimal nutrient solution, was investigated along the entire time-course of the experiment. After an exposure of 43 days, salinity induced a progressive decline in stomatal conductance that hampered A. donax growth through diffusional limitations to photosynthesis and, when combined with high P, reduced the electron transport rate. Isoprene emission from A. donax leaves was stimulated as Na+ concentration raised in leaves. Prolonged growth in P-enriched substrate did not significantly affect A. donax performance, but decreased isoprene emission from leaves. Prolonged exposure of A. donax to + NaP increased the leaf level of H2O2, stimulated the production of carbohydrates, phenylpropanoids, zeaxanthin and increased the de-epoxidation state of the xanthophylls. This might have resulted in a higher stress tolerance that allowed a fast and full recovery following stress relief. Moreover, the high amount of ABA-glucose ester accumulated in leaves of A. donax exposed to + NaP might have favored stomata re-opening further sustaining the observed prompt recovery of photosynthesis. Therefore, prolonged exposure to high P exacerbated the negative effects of salt stress in A. donax plants photosynthetic performances, but enhanced activation of physiological mechanisms that allowed a prompt and full recovery after stress.
Najdeno v: ključnih besedah
Povzetek najdenega: ...tolerance to a wide range of environmental stresses. The response of potted A. donax plants to...
Ključne besede: Arundo donax Phosphorus Salinity Stress tolerance Biomass production
Objavljeno: 20.04.2020; Ogledov: 295; Prenosov: 0
.pdf Polno besedilo (6,60 MB)

The multi-purpose role of hairiness in the lichens of coastal environments: Insights from Seirophora villosa (Ach.) Frödén
Elisabetta Bianchi, Renato Benesperi, Ilaria Colzi, Andrea Coppi, Lorenzo Lazzaro, Luca Paoli, Alessio Papini, Sara Pignattelli, Corrado Tani, Pamela Vignolini, Cristina Gonnelli, 2019, izvirni znanstveni članek

Opis: The fruticose epiphytic lichen Seirophora villosa, strictly associated with Juniperus shrublands in the Mediterranean basin, was used to investigate the role of hairiness on a lichen thallus, as a characteristic morphological trait. We evaluated the effect of hair removal on the physiological parameters of a set of samples, during desiccation and on exposure to different salt concentrations. Hairy thalli were less affected by salt, suggesting that during dehydration, the presence of hair protects the thallus from light irradiance, oxidative stresses and the lipid peroxidation generated by free radicals, and could offer passive, but selective, water control. Our results showed that hair could not only increase thallus surface and promote water absorption when availability is low, but could also repel the salt dissolved in water by activating a passive resistance mechanism, by preventing salt entering.
Najdeno v: ključnih besedah
Ključne besede: Antioxidant activity Chlorophyll a fluorescence Juniperus shrublands Hair MDA Salt stress
Objavljeno: 20.04.2020; Ogledov: 302; Prenosov: 0
.pdf Polno besedilo (9,03 MB)

Impact of high or low levels of phosphorus and high sodium in soils on productivity and stress tolerance of Arundo donax plants
Claudia Cocozza, Federico Brilli, Laura Miozzi, Sara Pignattelli, Silvia Rotunno, Cecilia Brunetti, Cristiana Giordano, Susanna Pollastri, Mauro Centritto, Gian Paolo Accotto, Roberto Tognetti, Francesco Loreto, 2019, izvirni znanstveni članek

Opis: The potential of Arundo donax to grow in degraded soils, characterized by excess of salinity (Na+), and phosphorus deficiency (-P) or excess (+P) also coupled with salinity (+NaP), was investigated by combining in vivo plant phenotyping, quantification of metabolites and ultrastructural imaging of leaves with a transcriptome-wide screening. Photosynthesis and growth were impaired by+Na, -P and+NaP. While+Na caused stomatal closure, enhanced biosynthesis of carotenoids, sucrose and isoprene and impaired anatomy of cell walls, +P negatively affected starch production and isoprene emission, and damaged chloroplasts. Finally, +NaP largely inhibited photosynthesis due to stomatal limitations, increased sugar content, induced/repressed a number of genes 10 time higher with respect to+P and+Na, and caused appearance of numerous and large plastoglobules and starch granules in chloroplasts. Our results show that A. donax is sensitive to unbalances of soil ion content, despite activation of defensive mechanisms that enhance plant resilience, growth and biomass production of A. donax under these conditions.
Najdeno v: ključnih besedah
Ključne besede: Abiotic stress Giant reed Isoprene emission Phosphorus Salinity Transcriptome
Objavljeno: 20.04.2020; Ogledov: 291; Prenosov: 0
.pdf Polno besedilo (10,07 MB)

Under fungal attack on a metalliferous soil: ROS or not ROS? Insights from Silene paradoxa L. growing under copper stress
Cosimo Taiti, Elisabetta Giorni, Ilaria Colzi, Sara Pignattelli, Nadia Bazihizina, Antonella Buccianti, Simone Luti, Luigia Pazzagli, Stefano Mancuso, Cristina Gonnelli, 2016, izvirni znanstveni članek

Opis: We investigated how the adaptation to metalliferous environments can influence the plant response to biotic stress. In a metallicolous and a non-metallicolous population of Silene paradoxa the induction of oxidative stress and the production of callose and volatiles were evaluated in the presence of copper and of the PAMP fungal protein cerato-platanin, separately and in combination. Our results showed incompatibility between the ordinary ROS-mediated response to fungal attack and the acquired mechanisms of preventing oxidative stress in the tolerant population. A similar situation was also demonstrated by the sensitive population growing in the presence of copper but, in this case, with a lack of certain responses, such as callose production. In addition, in terms of the joint behaviour of emitted volatiles, multivariate statistics showed that not only did the populations respond differently to the presence of copper or biotic stress, but also that the biotic and abiotic stresses interacted in different ways in the two populations. Our results demonstrated that the same incompatibility of hyperaccumulators in ROS-mediated biotic stress signals also seemed to be exhibited by the excluder metallophyte, but without the advantage of being able to rely on the elemental defence for plant protection from natural enemies.
Najdeno v: ključnih besedah
Ključne besede: Biotic interactions Callose Heavy metals Oxidative stress VOCs
Objavljeno: 20.04.2020; Ogledov: 275; Prenosov: 0
.pdf Polno besedilo (6,63 MB)

Verb wasn't built in a cycle (it was built in two)
Marko Simonović, Petra Mišmaš, objavljeni povzetek znanstvenega prispevka na konferenci

Opis: In this talk, we focus on verbs and argue that verbs lack prosodic specification in their lexical entry. We propose that the two different stress patterns in verbs are a consequence of two positions for theme vowels in the verbal domain. Assuming that Slovenian prosody places stress at the final syllable of the deepest cycle (Simonović under review), we argue that the verb forms that surface with a stressed theme vowel (e.g. godrnj-á-mo) have the theme vowel positioned just below the first cyclic head, whereas the remaining verbs have their theme vowel above this position which leads to stem-final stress (vijúg-a-mo).
Najdeno v: ključnih besedah
Povzetek najdenega: ...entry. We propose that the two different stress patterns in verbs are a consequence of...
Ključne besede: verbs, stress, root allomorphy, Slovenian, Distributed Morphology
Objavljeno: 07.09.2020; Ogledov: 114; Prenosov: 0
.pdf Polno besedilo (126,96 KB)

Think globally, act locally
Marko Simonović, Petra Mišmaš, prispevek na konferenci brez natisa

Opis: Slovenian is one of the languages used as a source of data for a model of non-local allomorphy in Božič (2019). Specifically, Božič (2019: 501) argues for non-local allomorphy in Slovenian because the root of the verb can differ depending on the finiteness of the form and this interaction occurs across the theme vowel (ž-e-ti ‘to reap’ vs. žanj-e-m ‘I reap’). In this talk we will, based on observations in Marvin (2003), propose a general account of theme vowels in Slovenian as the spellout of the v head and present additional data in favor of the more traditional analysis že-∅-ti~žanj-e-m (e.g. in Šekli 2010), which only involves local allomorphy.
Najdeno v: ključnih besedah
Povzetek najdenega: ...verbs, Slovenian, allomorphy, stress, theme vowels, spellout...
Ključne besede: verbs, Slovenian, allomorphy, stress, theme vowels, spellout
Objavljeno: 24.09.2020; Ogledov: 132; Prenosov: 0
.pdf Polno besedilo (169,08 KB)

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