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51.
Whole-cell biopanning with a synthetic phage display library of nanobodies enabled the recovery of follicle-stimulating hormone receptor inhibitors
Ronan Crepin, Gianluca Veggiani, Selma Djender, Anne Beugnet, Francois Planeix, Christophe Pichon, Sandrine Moutel, Sebastian Amigorena, Franck Pérez, Nicolae Ghinea, Ario De Marco, 2017, izvirni znanstveni članek

Opis: Antibodies are essential reagents that are increasingly used in diagnostics and therapy. Their specificity and capacity to recognize their native antigen are critical characteristics for their in vivo application. Follicle-stimulating hormone receptor is a GPCR protein regulating ovarian follicular maturation and spermatogenesis. Recently, its potentiality as a cancer biomarker has been demonstrated but no antibody suitable for in vivo tumor targeting and treatment has been characterized so far. In this paper we describe the first successful attempt to recover recombinant antibodies against the FSHR and that: i) are directly panned from a pre-immune library using whole cells expressing the target receptor at their surface; ii) show inhibitory activity towards the FSH-induced cAMP accumulation; iii) do not share the same epitope with the natural binder FSH; iv) can be produced inexpensively as mono- or bivalent functional molecules in the bacterial cytoplasm. We expect that the proposed biopanning strategy will be profitable to identify useful functional antibodies for further members of the GPCR class.
Ključne besede: nanobodies, GPCR proteins, FSHR, panning, pre-immune antibody library
Objavljeno: 19.10.2017; Ogledov: 118; Prenosov: 0
.pdf Polno besedilo (982,69 KB)

52.
Reducibility in hypergroups (crisp and fuzzy case)
Irina Cristea, 2015, objavljeni znanstveni prispevek na konferenci

Ključne besede: fundamental relations, reduced hypergroup, fuzzy reduced hypergroup, fuzzy grade
Objavljeno: 18.10.2017; Ogledov: 139; Prenosov: 0
.pdf Polno besedilo (300,72 KB)

53.
Slovenian questions with short wh-movement and the low periphery
Petra Mišmaš, 2017, izvirni znanstveni članek

Ključne besede: wh-movement, wh-questions, topic phrase, focus phrase, wh-phrase, low periphery Slovenian, syntax, cartography
Objavljeno: 18.10.2017; Ogledov: 111; Prenosov: 0
.pdf Polno besedilo (750,87 KB)

54.
Simulations of Tidal Disruption Events Observations with the LSST
Katja Bricman, 2017, magistrsko delo

Opis: The Large Synoptic Survey Telescope (LSST) will produce a multi-colour survey of 25000 square deg of the Southern sky during its 10 years of operations. It will observe over 20 billion galaxies and a similar number of stars, map the Solar System and the Milky Way, and probe dark matter and dark energy. In addition, it will discover thousands of transients every night, including new classes of objects, which have not yet been observed. Due to its large coverage of the sky it will be a perfect tool for the search of rare Tidal Disruption Events (TDEs), which occur when a star passes close by a supermassive black hole and gets disrupted by its tidal force. Afterwards the stellar debris fall back to the black hole, initially at a rate exceeding the Eddington rate, producing an outflow, which releases a flare of energy. When the fallback rate subsides below the Eddington rate, the gas accretes onto the black hole via accretion disk. The LSST simulation framework enables us to simulate observations of different types of objects with the LSST. In this work, we include TDEs in the LSST simulation framework, estimate the number of detected TDEs, and simulate their light curves using a theoretical model, which predicts a t^(-2.6) light curve decline with time in the outflow phase and a t^{-0.4} decline in the disk phase. We also take a closer look at the distribution of the detected TDEs over cosmological redshift and black hole mass.
Ključne besede: Astronomical observations, Large Synoptic Survey Telescope, Tidal Disruption Events, Black Holes, simulations
Objavljeno: 17.10.2017; Ogledov: 110; Prenosov: 0
.pdf Polno besedilo (8,73 MB)

55.
Povezovanje hierarhije pridevnikov v samostalniški zvezi in kognicije
Petra Mišmaš, Franc Marušič, 2017, objavljeni povzetek znanstvenega prispevka na konferenci

Ključne besede: pridevniki, kognicija, samostalniška zveza, kartografija, skladnja
Objavljeno: 16.10.2017; Ogledov: 96; Prenosov: 0
.pdf Polno besedilo (315,62 KB)

56.
Kaj nam usvajanje nejezikovnih prvin pove o ustroju jezika
Tjaša Popovič, Petra Mišmaš, Rok Žaucer, 2017, objavljeni povzetek znanstvenega prispevka na konferenci

Ključne besede: usvajanje, pridevniki, koncepti, kognicija, kartografija, skladnja
Objavljeno: 16.10.2017; Ogledov: 112; Prenosov: 0
.pdf Polno besedilo (447,79 KB)

57.
Ostati sam v času, ki ga ni
Rok Andres, 2017, strokovni članek

Ključne besede: Vinko Möderndorfer, Tri ženske, Prešernovo gledališče Kranj, dramatika, gledališče
Objavljeno: 16.10.2017; Ogledov: 100; Prenosov: 0
.pdf Polno besedilo (1,85 MB)

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Sadovnjak Pod skalco v Kojskem - 150 starih sadnih sort
Zoran Božič, druga izvedena dela

Opis: Predstavitev Goriške kot sadjarske regije in sadovnjaka Pod skalco (genetske banke), s poudarkom na nastanku in značilnostih (visokodebelne podlage, sajenje, gnojenje in škropljenje, najbolj zanimive sorte) ter predstavitev publikacij Stare sadne sorte na Goriškem in Sadje sonca: bogastvo starih briških sadnih sort.
Ključne besede: travniški sadovnjak, visokodebelni sadovnjak, Goriška Brda, ekološka pridelava, sadjarstvo, agronomija, Avstro-Ogrska, trženje sadja, podlage za cepljenje, gnojenje, škropljenje, drevesnica Omezzolli, drevesnica Dal Monte, Riva del Garda, Brisighella, kmetijstvo
Objavljeno: 16.10.2017; Ogledov: 84; Prenosov: 3
.pdf Polno besedilo (14,85 MB)

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