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2182. |
2183. Diversity of bacteria and bacterial products as antibiofilm and antiquorum sensing drugs against pathogenic bacteriaFazlurrahman Khan, Sandra Oloketuyi, Young-Mog Kim, 2019, pregledni znanstveni članek Opis: The increase in antibiotic resistance of pathogenic bacteria has led to the development of new therapeutic approaches to inhibit biofilm formation as well as interfere quorum sensing (QS) signaling systems. The QS system is a phenomenon in which pathogenic bacteria produce signaling molecules that are involved in cell to cell communication, production of virulence factors, biofilm maturation, and several other functions. In the natural environment, several non-pathogenic bacteria are present as mixed population along with pathogenic bacteria and they control the behavior of microbial community by producing secondary metabolites. Similarly, non-pathogenic bacteria also take advantages of the QS signaling molecule as a sole carbon source for their growth through catabolism with enzymes. Several enzymes are produced by bacteria which disrupt the biofilm architecture by degrading the composition of extracellular polymeric substances (EPS) such as exopolysaccharide, extracellular- DNA and protein. Thus, the interference of QS system by bacterial metabolic products and enzymatic catalysis, modification of the QS signaling molecules as well as enzymatic disruption of biofilm architecture have been considered as the alternative therapeutic approaches. This review article elaborates on the diversity of different bacterial species with respect to their metabolic products as well as enzymes and their molecular modes of action. The bacterial enzymes and metabolic products will open new and promising perspectives for the development of strategies against the pathogenic bacterial infections.
Ključne besede: Bacteria, biofilm, quorum sensing, inhibition, metabolites, pathogen, virulence.
Objavljeno v RUNG: 18.01.2021; Ogledov: 2404; Prenosov: 0
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2184. |
2185. Treatment strategies targeting persister cell formation in bacterial pathogensFazlurrahman Khan, Dung Pham, Nazia Tabassum, Sandra Oloketuyi, Young-Mog Kim, 2020, pregledni znanstveni članek Opis: Persister cells are transiently antibiotic-tolerant and dormant subpopulations that are produced to escape the effects of antibiotics within biofilms or planktonic cell populations. Persister cells are of high clinical importance due to their tolerance to antimicrobial agents and subsequent failure in antibiotic treatments. Understanding persister cell formation mechanisms is therefore highly important for developing effective therapeutic strategies against pathogenic bacterial persisters. Several anti-persister compounds have been previously identified via isolation from natural resources or chemical synthesis. Furthermore, a combination of these compounds with antibiotics or non-antibiotic drugs also allows action on multiple targets while reducing the administration frequency. Here, we present a comprehensive overview of the clinical importance and formation mechanisms of persister cells as well as the current treatment strategies against persister cell formations in chronic infections.
Ključne besede: Biofilm, anti-persister agents, persister cells, pathogenic bacteria, chronic infections
Objavljeno v RUNG: 14.01.2021; Ogledov: 2612; Prenosov: 0
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2186. Molecules involved in motility regulation in Escherichia coli cells: a reviewFazlurrahman Khan, Nazia Tabassum, Dung :Pham, Sandra Oloketuyi, Young-Mog Kim, 2020, izvirni znanstveni članek Opis: The initial colonization of the host organism by commensal, probiotic, and pathogenic Escherichia coli strains is an important step in the development of infections and biofilms. Sensing and colonization of host cell surfaces are governed by flagellar and fimbriae/pili appendages, respectively. Biofilm formation confers great advantages on pathogenic E. coli cells such as protection against the host immune system, antimicrobial agents, and several environmental stress factors. The transition from planktonic to sessile physiological states involves several signaling cascades and factors responsible for the regulation of flagellar motility in E. coli cells. These regulatory factors have thus become important targets to control pathogenicity. Hence, attenuation of flagellar motility is considered a potential therapy against pathogenic E. coli. The present review describes signaling pathways and proteins involved in direct or indirect regulation of flagellar motility. Furthermore, application strategies for antimotility natural or synthetic compounds are discussed also.
Ključne besede: Biofilm formation, Escherichia coli, inhibition, motility, pathogenesis
Objavljeno v RUNG: 14.01.2021; Ogledov: 3601; Prenosov: 0
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2187. Scientific Advancement in Contemporary Society: Interface between Technology, Law and ScienceAdetutu Aina-Pelemo, Ananya Patil, Paul Ejembi, Sandra Oloketuyi, Iseoluwa Aina, 2019, izvirni znanstveni članek Opis: This article is premised on the relation of technology and applied sciences with law. The three subjects are not only interwoven but cannot be protected and regulated without the viable use of law. The unprecedented advancement ofscientific innovations has far-reaching implication in virtually all ramifications of human endeavour. Technology is an invention created using science, which needs to be sustained by prudent management and law. The research goal is to narrow down a middle ground where all these independent fields can meet and share a symbiotic relationship without stifling each other. The research seeks to ascertain the knowledge and perception of selected university students of Nigeria and India, about Science, Law and Technology. The authors adopted the doctrinal and empirical research methodology coupled with the use of cases and legislations as source of information. The research revealed that majority of the participants has knowledge about the co-existence and impact of Science, Technology and Law in the society. However, the attitude and perception of the participants constitute a fundamental influence on the degree to which technological orientations occur during learning process. Also, 85% of 200 participants agreed that there is need for frequent education and legislation as science and technology evolves in the society. Hence, this article recommends the implementation and frequent modifications of law to continually protect, encourage and ensure the societal sustainability of ethical standards.
Ključne besede: Advancement, Law, Relations, Science, Sustainability, Technology
Objavljeno v RUNG: 14.01.2021; Ogledov: 2273; Prenosov: 0
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2188. Chitosan and their derivatives: Antibiofilm drugs against pathogenic bacteriaFazlurrahman Khan, Dong Pham, Sandra Oloketuyi, Panchanathan Manivasagan, Junghwan Oh, Young-Mog Kim, 2020, pregledni znanstveni članek Opis: Biofilm formed by several pathogenic bacteria results in the development of resistance against antimicrobial compounds. The polymeric materials present in the biofilm architecture hinder the entry of antimicrobial compounds through the surface of bacterial cells which are embedded as well as enclosed beneath the biofilm matrix. Recent and past studies explored the alternative approaches to inhibit the formation of biofilm by different agents isolated from plants, animals, and microbes. Among these agents, chitosan and its derivatives have got more attention due to their properties such as biodegradability, biocompatibility, non-allergenic and non-toxicity. Recent researches have focused on employing chitosan and its derivatives as effective agents to inhibit biofilm formation and attenuate virulence properties by various pathogenic bacteria. Such antibiofilm activity of chitosan and its derivatives can be further enhanced by conjugation with a wide range of bioactive compounds. The present review describes the antibiofilm properties of chitosan and its derivatives against the pathogenic bacteria. This review also summarizes the mechanisms of biofilm inhibition exhibited by these molecules. The knowledge of the antibiofilm activities of chitosan and its derivatives as well as their underlying mechanisms provides essential insights for widening their applications in the future.
Ključne besede: Antibiofilm, Biofilm inhibition, Chitosan, Chitosan derivatives, Pathogenic bacteria
Objavljeno v RUNG: 14.01.2021; Ogledov: 2327; Prenosov: 0
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2189. Antimicrobial efficacy and phytochemical screening of Mushrooms, Lenzites betulinus, and Coriolopsis gallica extracts.Soji Fakoya, Sandra Oloketuyi, 2012, izvirni znanstveni članek Opis: AIM: The spread of multidrug-resistant strains of bacteria makes it necessary to discover new classes of
antibacterial and compounds that inhibit these resistant mechanisms. Hence, this study was conducted to
evaluate the antimicrobial activities of Lenzites betulinus and Coriolopsis gallica extracts against some
bacterial isolates of medical importance.
METHOD: The organisms are Pseudomonas aeruginosa, Staphylococcus aureus, Proteus vulgaris,
Klebsiella pneumoniae, Escherichia coli. Using agar well diffusion assay, the ethanolic, petroleum ether
and aqueous extract of C. gallica was assayed against the bacterial isolates and the result showed that
Petroleum ether extract of C. gallica and L. betulinus was able to inhibit P. vulgaris with inhibition
zones of 26.0 mm and 20.0 mm respectively.
RESULTS: Ethanolic extract of C. gallica also inhibited P. vulgaris with inhibition zone of 22.0 mm
while aqueous extract and petroleum ether of L. betulinus inhibited P. aeruginosa with inhibition zones
of 20.0 mm and 23.0 mm respectively. E. coli and S. aureus were also inhibited by the aqueous and
ethanolic extract of L. betulinus with zones of inhibition 15.0 mm and 26.0 mm against E. coli while
19.0 mm and 22.0 mm against S. aureus respectively. This study also showed the presence of some
phytochemicals like tannins, phenolics, flavonoids, steroids, and saponin in the mushrooms with
antimicrobial effects against the bacterial isolates used.
CONCLUSION: The active components present in ethanolic, aqueous and petroleum ether extracts of
C. gallica include phenolics, flavonoids, and steroids while phytochemicals obtained from L. betulinus
are phenolics, tannins, flavonoids, and saponin respectively.
Ključne besede: Coriolopsis gallica, Lenzites betulinus, Antimicrobial, Phytochemicals, Bacterial İsolates
Objavljeno v RUNG: 14.01.2021; Ogledov: 2071; Prenosov: 0
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2190. Inhibition strategies of Listeria monocytogenes biofilms- Current knowledge and future outlooks.Sandra Oloketuyi, Fazlurrahman Khanna, 2017, pregledni znanstveni članek Opis: There is an increasing trend in the food industry on the Listeria monocytogenes biofilm formation and inhibition. This is attributed to its easy survival on contact surfaces, resistance to disinfectants or antibiotics and growth under the stringent condition used for food processing and preservation thereby leading to food contamination products by direct or indirect exposure. Though, there is a lack of conclusive evidences about the mechanism of biofilm formation, in this review, the concept of biofilm formation and various chemical, physical, and green technology approaches to prevent or control the biofilm formed is discussed. State-of-the-art approaches ranging from the application of natural to synthetic molecules with high effectiveness and non-toxicity targeted at the different steps of biofilm formation could positively influence the biofilm inhibition in the future.
Ključne besede: Listeria monocytogenes, biofilm, food industry, inhibition, pathogen
Objavljeno v RUNG: 14.01.2021; Ogledov: 2201; Prenosov: 0
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