3431. Enhancement of Charge Transport in Polythiophene Semiconducting Polymer by Blending with Graphene NanoparticlesEgon Pavlica, Gvido Bratina, 2019, izvirni znanstveni članek Opis: This paper describes a study on the charge transport in a composite of liquid‐exfoliated graphene nanoparticles (GNPs) and a polythiophene semiconducting polymer. While the former component is highly conducting, although it consists of isolated nanostructures, the latter offers an efficient charge transport path between the individual GNPs within the film, overall yielding enhanced charge transport properties of the resulting bi‐component system. The electrical characteristics of the composite layers were investigated by means of measurements of time‐of‐flight photoconductivity and transconductance in field‐effect transistors. In order to analyze both phenomena separately, charge density and charge mobility contributions to the conductivity were singled out. With the increasing GNP concentration, the charge mobility was found to increase, thereby reducing the time spent by the carriers on the polymer chains. In addition, for GNP loading above 0.2 % (wt.), an increase of free charge density was observed that highlights an additional key role played by doping. Variable‐range hopping model of a mixed two‐ and three‐dimensional transport is explained using temperature dependence of mobility and free charge density. The temperature variation of free charge density was related to the electron transfer from polythiophene to GNP, with an energy barrier of 24 meV.
Ključne besede: grafen, polimeri, transport električnega naboja, časovno odvisna fotoprevodnost
Objavljeno v RUNG: 23.08.2019; Ogledov: 2873; Prenosov: 0
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3432. Pregnancy and delivery in online communities: new ownership practices, new forms of technoscientific citizenshipGiulia Annovi, Yurji Castelfranchi, Chiara Saviane, Elena Bellio, Donatella Fontanot, Luca Buccoliero, Nico Pitrelli, Gianluigi Scannapieco, 2017, izvirni znanstveni članek Ključne besede: knowledge, expertise, collective learning, web, technoscientific citizenship
Objavljeno v RUNG: 23.08.2019; Ogledov: 2426; Prenosov: 0
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3433. New insights into autophagic cell death in the gypsy moth Lymantria dispar: a proteomic approach.Davide Malagoli, Federica Boraldi, Giulia Annovi, Daniela Quaglino, Enzo Ottaviani, 2009, izvirni znanstveni članek Opis: Autophagy is an evolutionary ancient process based on the activity of genes conserved from yeast to metazoan taxa. Whereas its role as a mechanism to provide energy during cell starvation is commonly accepted, debate continues about the occurrence of autophagy as a means specifically activated to achieve cell death. The IPLB-LdFB insect cell line, derived from the larval fat body of the lepidoptera Lymantria dispar, represents a suitable model to address this question, as both autophagic and apoptotic cell death can be induced by various stimuli. Using morphological and functional approaches, we have observed that the culture medium conditioned by IPLB-LdFB cells committed to death by the ATPase inhibitor oligomycin A stimulates autophagic cell death in untreated IPLB-LdFB cells. Moreover, proteomic analysis of the conditioned media suggests that, in IPLB-LdFB cells, oligomycin A promotes a shift towards lipid metabolism, increases oxidative stress and specifically directs the cells towards autophagic activity.
Ključne besede: Autophagic cell death, Fat body, IDGF, IPLB-LdFB, Proteomics
Objavljeno v RUNG: 23.08.2019; Ogledov: 2904; Prenosov: 0
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3434. A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing.Manuela Malatesta, Federica Boraldi, Giulia Annovi, Beatrice Baldelli, Serafina Battistelli, Marco Baggiogera, Daniela Quaglino, 2008, izvirni znanstveni članek Opis: Liver represents a suitable model for monitoring the effects of a diet, due to its key role in controlling the whole metabolism. Although no direct evidence has been reported so far that genetically modified (GM) food may affect health, previous studies on hepatocytes from young female mice fed on GM soybean demonstrated nuclear modifications involving transcription and splicing pathways. In this study, the effects of this diet were studied on liver of old female mice in order to elucidate possible interference with ageing. The morpho-functional characteristics of the liver of 24-month-old mice, fed from weaning on control or GM soybean, were investigated by combining a proteomic approach with ultrastructural, morphometrical and immunoelectron microscopical analyses. Several proteins belonging to hepatocyte metabolism, stress response, calcium signalling and mitochondria were differentially expressed in GM-fed mice, indicating a more marked expression of senescence markers in comparison to controls. Moreover, hepatocytes of GM-fed mice showed mitochondrial and nuclear modifications indicative of reduced metabolic rate. This study demonstrates that GM soybean intake can influence some liver features during ageing and, although the mechanisms remain unknown, underlines the importance to investigate the long-term consequences of GM-diets and the potential synergistic effects with ageing, xenobiotics and/or stress conditions.
Ključne besede: Genetically modified soybean, liver, mitochondria
Objavljeno v RUNG: 23.08.2019; Ogledov: 3232; Prenosov: 0
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