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31.
Depression between biomedicine and Ayurvedic medicine
Maja Kolarević, 2015, doktorska disertacija

Opis: The present work explores the "major depression", which falls in a psychiatric categorization of mental disorders in the spectrum of mood disorders. The subject of the research was the (de)construction of scientific knowledge of depression in terms of Indian medicine: Ayurveda and biomedicine /psychiatry, and the understanding of treatment, accompanied by an example of these two medical systems from the points of view of the patients in Slovenia, diagnosed with major depression. This dissertation represents multi-layered content analysis highly relevant to the field of mental health – to cope and deal with the depressive mood disorder, as one of the most common forms of mental health problems. To this end the following was conducted: (1) a comparison between the conceptualization and treatment of major depressive disorder in psychiatric and Ayurvedic theory, (2) an examination of Ayurveda practice transferred to a different cultural environment, i.e. in Slovenia, in comparison with the environment from which it comes, i.e. in India, (3) an identification of key factors that prompt them to undergo Ayurvedic or psychiatric practice, (4) an analysis and a comparison of the course and the outcome of the treatment using both approaches, and (5) a comparison of participants understandings of depression from the psychiatric and the Ayurvedic aspects using narrative approach. The purpose of this research was to examine the differences between the two approaches of treatment for depression arising from the different concepts of understanding its causes, its course and consequently its therapeutic intervention. The main focus lies on the advantages / disadvantages of compared practices as experienced by patients with depression. This issue is particularly important because, according to health statistics, depression today ranks among one of the most common forms of mental disorders, and its incidence is on the rise. This is not necessarily a reflection of the increased cases as such, but might also be attributed to the better recognition and greater awareness of depression by healthcare professionals and the general public. The effects of Ayurvedic practice as treatment of mental disorders are still relatively poorly examined, as well as the transfer of Ayurvedic medicine into a different cultural environment. Studies on the treatment of mental disorders with Ayurvedic medicine from the perspective of a European patient experience are few and there is a major gap in this research field. In my opinion, the dissertation would immensely contribute to the enormous research gap on the treatment of major depressive disorders with Ayurvedic practice in Slovenian territory. From the scientific point of view, the results of this research represent a significant development in our current understanding of the still prevailing concepts of medical theories and practices in the field of mental health.
Ključne besede: major depression, psychiatry, Ayurvedic medicine, medicalization, paramedicalization
Objavljeno: 15.12.2015; Ogledov: 1230; Prenosov: 87
.pdf Polno besedilo (1,85 MB)

32.
MOLECULAR MECHANISMS REGULATING ATP SIGNALING IN MOUSE SENSORY NEURONS
Tanja Bele, 2015, doktorska disertacija

Opis: Coordinated and harmonized neuronal and glial responses to variations in extracellular levels of active soluble mediators such as ATP are essential in controlling neuronal activity. In pathological conditions involving sensory nervous system, elevations in extracellular ATP levels are believed to be one of the main reason for neuronal sensitization. This notion led us to explore mechanisms of ATP release in sensory ganglia and we found that association among P2X purinergic receptors, their downstream effectors (CASK and CaMKII) and hemichannel Panx1 regulates inhibition of ATP release in basal conditions and that same players are involved in P2X3 receptor evoked-ATP release which globally suggest that even if observed proteins are expressed in different cells, they could be modulated by similar mechanisms and are possibly part of an “ATP-keeper molecular system” that finely regulates extracellular levels of ATP by its sensing and further adjustments of peculiar extracellular concentrations. Further we showed that P2X3 receptors interact with Panx1 in sensory neurons and that molecular coupling between P2X3, CASK and Panx1 contributes to decoding of the complex purinergic signaling involved in nociception which represents a novel and interesting mechanism of pain regulation that could be precisely targeted in order to alleviate tedious disorders of sensory neurons.
Ključne besede: ATP, ATP release, purinergic signaling, trigeminal ganglion, pain, migraine, P2X3, CASK, Pannexin-1, synaptic strength
Objavljeno: 10.12.2015; Ogledov: 1267; Prenosov: 57
.pdf Polno besedilo (3,75 MB)

33.
Ustno izročilo in kulturni spomin v zgornjem Obsotelju
Katarina Šrimpf, 2015, doktorska disertacija

Opis: Doktorska disertacija z naslovom Ustno izročilo in kolektivni spomin v zgornjem Obsotelju je celovita študija pripovednega izročila zgornjega Obsotelja, območja na slovenskem etničnem ozemlju. V uvodu prinaša predstavitev območja in krajev v treh raziskovanih občinah z zgodovinskega, gospodarskega pa tudi družbenega in kulturnega vidika ter predstavitev gradiva, tako starejšega, ki je bilo zbrano s pomočjo arhivskega dela, kot tudi novejšega, ki je bilo zbrano s terenskim delom. Gradivo je opisano in analizirano skozi žanrsko in tematsko strukturo. Drugi del disertacije je osredotočen na pomen in vlogo, ki jo imajo izbrani elementi pripovednega izročila v družbenem in kulturnem življenju obravnavanega območja. Kot ključni elementi za razumevanje pomena in vloge pripovedništva so se pokazali trije kriteriji: 1) percepcija prostora in časa, 2) konstruiranje identitet, 3) sodobna raba pripovedi in njihovih funkcij. Prostor in čas, kot se kažeta skozi pripovedno izročilo, sta koncipirana s pomočjo liminalnega časa in prostora ter etioloških povedk in zgodovinskih zgodb. Šaljive zgodbe o Lemberžanih ter zbadljivke in druge zgodbe o Hrvatih so v zgornjem Obsotelju priročno sredstvo za ločevanje ene skupine od druge, kar omogoča konstruiranje tako lokalnih kot nacionalnih in drugih identitet. Funkcijo vzbujanja občutka lokalne pripadnosti in vzpostavljanja lokalne identitete ima tudi sodobna raba lokalnega pripovednega izročila, ki je vzeto iz primarnega okolja. Poskus razumevanja pomenov in funkcij, ki jih ima ustno izročilo v lokalnem okolju, je glavna tema te disertacije.
Ključne besede: ustno izročilo, pripovedništvo, zgornje Obsotelje, percepcija prostora in časa, ustvarjanje identitet
Objavljeno: 04.12.2015; Ogledov: 1336; Prenosov: 98
.pdf Polno besedilo (5,95 MB)

34.
Earthen architecture, tradition and modernity: Local self construction through building tradition and technological innovation opportunities in Chiapas, Mexico
Karla Sánchez Torres, 2015, doktorska disertacija

Opis: Earthen architecture represents a long building tradition of numerous indigenous communities in Mexico, in particular in the state of Chiapas, where a significant number of examples represent a rich historical tradition of earthen architecture and a valuable source of information, hence a fertile ground for a deeper investigation on its potential significance and, more broadly, for a greater understanding of sustainable building today. Despite the fact that the relevance of earthen architecture is widespread all over the world, traditional earthen architecture in Chiapas is scarcely documented, it lacks systematic research projects aimed at preserving this important tradition of these indigenous groups who often live in precarious conditions. Hence, this research highlights not only the widespread employment of earth as a traditional building material for the indigenous groups of Chiapas, but also its additional function as being an authentic expression of the architectural legacy of indigenous culture and thus a key potential factor for the development of the self construction. The first part of the dissertation introduces a general overview and prevailing knowledge on earthen architecture, mainly through investigating the bibliographic, historical and technical sources as well as the particular studies on earthen architecture in Mexico. The second part discusses the results of the field studies related to the specific conditions of earthen architecture in Chiapas through sampling, testing, photographic reference and interviews. On analysing the results of the field studies it can be established that the local population has shown a particular interest in the continuity of the earthen building tradition, in spite of this period of far-reaching globalisation building trends. For this reason the final part of dissertation propooses the manual. The main objective of the manual is to improve the traditional earthen building system by introducing a number of minor variations to the building technologies and new sustainable suggestions for the management of the living space, without sacrificing the flair and simplicity found within the local building tradition, thus giving new opportunities for the development of local populations through the preservation of the earthen building tradition.
Ključne besede: earthen architecture, indigenous, self-construction, manual, tradition, local communities
Objavljeno: 01.12.2015; Ogledov: 1072; Prenosov: 8
.pdf Polno besedilo (34,58 MB)

35.
Diagnostic and prognostic markers in canine inflammatory and neoplastic head and neck conditions
Ana Rejec, 2015, doktorska disertacija

Opis: Several different types of conditions with inflammatory and neoplastic background affect the anatomical localities of the head and neck in a dog. It is a well-recognized fact that these conditions affect the quality of life, as they are associated with various degree of regional dysfunction, have systemic effects and can be direct or indirect cause of death. Unfortunately, many dogs with both inflammatory and neoplastic head and neck conditions are presented at an advanced stage of the disease which can have significant impact on treatment strategies. The identification of biomarkers is advisable to enhance effective staging, grading and prognostication, which will in turn more accurately direct recommendations for therapy. These biomarkers can theoretically help to distinguish between inflammatory and neoplastic conditions, justify the management of patients more accurately and potentially predict the prognosis and the survival of patients. It was our interest to investigate the diagnostic and prognostic value of complete blood count parameters and indices in dogs with head and neck conditions of inflammatory and neoplastic origin, regulatory T cells in dogs with periodontal disease, immunohistochemical (Ki-67 and VEGFR-2) and histopathological biomarkers in dogs with inflammatory and neoplastic head and neck conditions and to evaluate the effectiveness of an accelerated radiotherapy protocol for the treatment of advanced canine HNSCC. We have proved that the parameters investigated might serve as important supportive diagnostic and/or prognostic biomarkers which might help to improve the treatment strategies of both inflammatory and neoplastic head and neck conditions in dogs and that the accelerated chemoradiotherapy protocol represents an effective alternative treatment option for dogs with advanced HNSCC.
Ključne besede: biomarkers, dogs, periodontal disease, regulatory T cells, head and neck tumours, complete blood count, radiotherapy, vascular endothelial growth factor receptor 2
Objavljeno: 26.11.2015; Ogledov: 1237; Prenosov: 19
.pdf Polno besedilo (59,54 MB)

36.
Aspects of micro black hole evaporation
Saeede Nafooshe, 2015, doktorska disertacija

Ključne besede: micro black holes, evaporation, gravitons, grey-body factors, large dimensions, quasi-normal modes, Vaidya metric
Objavljeno: 17.11.2015; Ogledov: 1560; Prenosov: 96
.pdf Polno besedilo (3,14 MB)

37.
On the Optionality of Wh-Fronting in a Multiple Wh-Fronting Language
Petra Mišmaš, 2015, doktorska disertacija

Opis: This thesis explores the fact that in Slovenian multiple wh-questions not all wh-phrases have to front. This suggests that multiple wh-movement in Slovenian is optional. The majority of the existing literature on multiple wh-fronting focuses on questions in which all wh-phrases have to move to clause initial positions, I, on the other hand, focus on optionality in multiple wh-questions. I show movement in Slovenian is not avoided because of phonological, syntactic or semantic restrictions that influence other languages (cf. Bošković 2002), and that the Principle of Distinctness (Richards 2010) does not account for all cases of optional multiple wh-fronting in Slovenian. Three types of multiple wh-questions in Slovenian are determined and analyzed: (i) questions in which all wh-phrases move to clause initial positions (i.e. questions with multiple wh-fronting), (ii) questions in which one wh-phrase has to be moved to a clause initial position and the rest undergo movement to a clause internal position (multiple wh-questions with short movement), (iii) questions in which at least one wh-phrase has to be moved to a clause initial position and the rest stay in situ (multiple wh-questions with wh-in-situ). Crucially, in all three types at least one wh-phrase has to move to a clause initial position for a question to receive a true question reading. I assume the Cartographic approach and propose an account of multiple wh-fronting in Slovenian in which one wh-phrase has to move to an Interrogative Projection (the clause initial position) in the Left Periphery while the remaining wh-phrases move to Wh-Projections in the Left Periphery, questions in (i), or the Low Periphery, questions in (ii). I propose that wh-phrases with a wh-feature undergo wh-movement, which means that wh-movement is in fact obligatory in Slovenian. In questions of type (iii), wh-phrases that do not undergo movement are in fact bare wh-pronouns, which one also finds in polarity contexts, that are licensed by the interpretable Q+wh-feature located in the Interrogative Projection. Because the bare wh-pronouns do not come with a wh-feature, they do not have to move. I conclude that wh-movement in Slovenian only appears to be optional.
Ključne besede: multiple wh-fronting, short movement, optionality, Interrogative Projection, Left Periphery, Low Periphery, bare wh-pronouns, wh-in-situ
Objavljeno: 10.11.2015; Ogledov: 2032; Prenosov: 116
.pdf Polno besedilo (1,43 MB)

38.
EXPLORING BIODIVERSITY POTENTIAL OF WINE ASSOCIATED YEASTS
Sofia Dashko, 2015, doktorska disertacija

Opis: Human exploitation of yeast fermentation dates back to the Neolithic. S. cerevisiae has been the most important yeast used for numerous fermentations of biotechnological interest, including grape fermentation for wine production. Despite its abundant use, the molecular mechanisms controlling alcoholic fermentation are rather unclear and the choice of S. cerevisiae as an inoculum is often the consequence of a mere habit, rather than the result of rational analyses. In this work we focused on the role of different yeasts in the winemaking process. I was interested in understanding how the specific strain used for inoculum could influence the wine aroma formation. Furthermore, I wished to investigate the yeast genetics and ecology by characterizing their population and strain diversity in one of the wine regions of Slovenia. To evaluate the effect of the yeast species on the fermentation outcome, we performed successive fermentations with five different species in combination with the industrial strain S. cerevisiae Lalvin T73. The experiment showed that at least two more yeast species, Kazachstania gamospora and Zygosaccharomyces kombuchaensis have good potential to be applied in the winemaking. , The main conclusions of this study are the possibility of: i) expanding the palette of alternative starters to widen the aromatic components ii) co–fermenting using two different yeast species. Mixed yeast culture fermentations are present in the natural context, but this practice has been neglected in biotechnological processes. Positive results of wine fermentations with non – conventional yeast urged us to explore the diversity of Slovenian wine region natural isolates. The resulting yeast collection counts more than 1200 strains for which phenotype and genotype have been defined. Numerous isolates, including non – Saccharomyces species, showed promising oenological and biotechnological traits because of their capacity of rapid utilization of various carbon sources, growth at low pH and at presence of copper sulfite and potassium metabisulfite. Sampling also revealed sharp discrimination between the ecological niches of S. cerevisiae and S. paradoxus, which is a striking feature of European vineyards. While S. cerevisiae habitats are strongly associated with human activity, S. paradoxus was mainly isolated from the forest sources. Profound analysis of the collected data could give some explanations to the driving forces of S. cerevisiae domestication and S. paradoxus geographic isolation population structure.
Ključne besede: Yeasts, biodiversity, molecular biology, alcoholic fermentation
Objavljeno: 02.11.2015; Ogledov: 1980; Prenosov: 18
.pdf Polno besedilo (41,27 MB)

39.
Radioactive isotopes in ground waters of Slovenia
Katarina Kovačič, 2015, doktorska disertacija

Opis: Within the duration of three projects (J7-0363, L1-0437, L1-4280), in the period from 2008 to 2013, measurements of tritium (3H), 40K and γ-ray emitters of uranium (238U, 226Ra and 210Pb) and thorium (228Ra and 228Th) decay series in groundwaters of Slovenia were carried out. Tritium was also measured in precipitation at selected locations. Groundwater sampling sites were selected in order to cover the most representative lithological units that are found in Slovenia and were at the same time evenly distributed throughout the country. In total, 281 samples were measured from 120 different locations. Measurements in the period 2009-2013 have shown that tritium concentrations in precipitation in Ljubljana are for about 30% lower compared to those in Vienna, however they are in line with seasonal fluctuations observed in Vienna. This was an important information in the process of the reconstruction of past tritium concentrations in precipitation in Ljubljana (tritium curve) for the missing period between 1953 and 1981. Tritium curve represents the input data when determining the average age of water. In determining the influence of various parameters on the final interpretation of the groundwater age it has been found that the greatest uncertainty contribute the measurements of the tritium curve and the measurements of tritium in groundwater samples. Also, the interaction of other factors (continental effect, rainfall regime, infiltration) and the lack of knowledge of them may have a major impact on the misinterpretation of groundwater age. Based on tritium concentration, groundwaters were divided into 4 major categories, into groundwaters that are older than 100 years (tritium concentration was below the detection limit), groundwaters, where the older component prevails (concentration of tritium was between 0 and 2.5 TU), groundwaters with the age between 30 and 60 years (the concentration of tritium was on average 8 TU) and recent groundwaters with age up to 15 years (tritium concentration of about 6 TU). The natural background of γ-ray emitters was determined for each lithological unit. The most represented radionuclide was 40K with concentrations always above the detection limit. A dependency of 40K concentrations on nitrate was observed, especially in the recharge areas, where limestone prevailed. Other γ-ray emitters revealed some dependence on nitrate concentration, especially both radium isotopes (226Ra and 228Ra). The concentration of 210Pb in groundwaters is mainly due to the connection with the surface and consequently with atmospheric 210Pb. The highest concentrations of 238U and 228Ra were measured in groundwaters from recharge areas in clastic rocks with a clay component. In contrast to the expected, concentrations for all γ-ray emitters (except 210Pb) were the lowest or even not detectable, in groundwaters from recharge areas in igneous and metamorphic rocks. Among γ-ray emitters and categorization based on tritium concentrations, elevated concentrations of 238U were observed in groundwaters with prevailing older component. Elevated concentrations of 40K were also observed in them. The largest scattering of 210Pb and 40K concentrations was observed in recent waters, which indicates a connection with the surface and application of fertilizers.
Ključne besede: Groundwaters, Slovenia, tritium input curve, natural gamma-ray emitters background.
Objavljeno: 05.10.2015; Ogledov: 1482; Prenosov: 43
.pdf Polno besedilo (8,62 MB)

40.
Development of Advanced TiO2/SiO2 Photocatalyst for Indoor Air Cleaning
Andraž Šuligoj, 2015, doktorska disertacija

Opis: TiO2 - SiO2 composites were synthesized by low-temperature sol-gel impregnation method, using four different titania sources (P-25 from Degussa, PC500 from Millennium, CCA 100 AS and CCA 100 BS from Cinkarna, later denoted as AS and BS, respectively) and deposited on aluminium and glass carriers. Ordered and disordered mesoporous silicas were impregnated with ce{TiO2} in powder or suspension form in the Ti : Si molar ratio 1 : 1. Structure, size, band gap, chemical composition and specific surface area of nanoparticles were determined by X-ray diffraction (XRD), scanning (SEM) and transmission electron microscopy (TEM), UV-vis diffuse reflectance spectroscopy (DR-UV-vis), Fourier transform infrared spectroscopy (FT-IR) and ce{N2} physisorption. Additionally, quantity of surface hydroxyl groups, surface acidity and mechanical stability of the coatings were determined by temperature programmed Fourier transform infrared spectroscopy (TPD-IR) and Wolff-Wilborn method, respectively. The photocatalytic activity of TiO2 and TiO2 - SiO2 composites was evaluated in the photodegradation of toluene and formaldehyde, as model VOCs, under UVA light irradiation in lab-made photoreactor system with two different regimes; batch and plug-flow mode. These two VOCs are being considered as examples of two of the six major classes of indoor air contaminants. Adsorption properties of the samples with toluene, have shown that the addition of mesoporous silica was beneficial. The increase of the adsorption of the bare AS TiO2 (9.5 %) was higher in the case of ordered silica, SBA-15 (2.8 times for AS/SBA15 to 26.8 %) than disordered SiO2 KIL-2 (2.4 times for AS/KIL2 to 22.7 %) although it was significant in both types of mesoporous silica supports (over 20 %). Adsorption was found to be dependent mostly on the quantity of surface Si-OH groups. Regarding the photocatalytic activities towards toluene degradation, the results with pure TiO2 showed the fastest kinetics in case of sample AS followed by PC500 and P25. The observed behaviour was ascribed to smaller particle size, and consequently higher specific surface area. Grafting titania onto silica showed the importance of structural parameters. Most importantly, if the pore structure of bare TiO2 collapsed, this resulted in decreased activity. On the other hand, retainment of the pore structure improved the distribution of nanoparticles, crystallinity and optical properties, which resulted in improved photocatalytic activity. In the degradation of formaldehyde, it was found that adsorption and degradation abilities of the materials were much more dependent on the structural properties of the samples, i.e., the pore structure. This was explained as a consequence of the different degradation mechanisms of both pollutants. Toluene degradation is governed by the oxidation through photogenerated holes - direct oxidation, whereas in the degradation of formaldehyde, the major oxidative species are OH radicals. In addition, the same as in toluene oxidation, the activity was dependent mainly on the number of crystal defects and the band gap values, that is the oxidation and reduction potentials of the catalysts. The degradation efficiency was increased from 88 % in pure AS TiO2 to 97 % when this titania was grafted onto colloidal silica (7C). An important highlight of the thesis is synthesis of a novel photocatalyst, labelled AS7C, which comprises an acidic colloidal suspension AS as TiO2 source and colloidal silica, using a low-temperature sol-gel impregnation method. This sample used all the above mentioned properties that improve photocatalytic activity towards both pollutants. Mechanical stability of the samples was also tested. The tests showed that binder, in the form of colloidal SiO2 (in size of 25 nm) in combination with colloidal titania of appropriate size - 6 nm, produced the highest mechanical stability of the coatings, which also showed excellent photocatalytic activity. Stability of the coatings, using AS as titania source, was greatly improved. The Wolff-Wilborn test on AS coating showed no mechanical resistance, while with the optimal (in terms of photocatalytic performance) addition of 7C SiO2 binder stability was excellent (F, which is in the middle of 6B-6H hardness scale). This sample (AS7C) was also tested for release of aerosols, during operation of the reactor, which could be harmful for human health at longer exposure times. It was found that aerosols are formed, probably as a consequence of detachment of nanoparticles in the first period of photodegradation test. However, their formation in consecutive tests was greatly reduced. Last but not least, a pilot plug-flow reactor was constructed to test the photocatalyst's efficiency in one-pass degradation of toluene. Sample AS7C was able to degrade toluene at conditions applied (v= 400 mL/min, m(catalyst) = 1049 mg, C(0) = 1 ppmv), which means that the out-flow from reactor was clean of the pollutant and any possible intermediates, comprising only of humid air and CO2. Deactivation of the catalyst was found at higher air flow and higher initial concentration of the pollutant. However, the concentrations of pollutants in living conditions are few orders of magnitude lower, hence this is a promising result.
Ključne besede: Air remediation, TiO2 photocatalysis, Immobilization, Thin layers, TiO2/SiO2 composites
Objavljeno: 31.08.2015; Ogledov: 2101; Prenosov: 50
.pdf Polno besedilo (33,47 MB)

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