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Raman LIDARs and atmospheric calibration along the line-of-sight of the Cherenkov Telescope Array
Samo Stanič, Longlong Wang, Marko Zavrtanik, 2019, objavljeni znanstveni prispevek na konferenci

Opis: The Cherenkov Telescope Array (CTA) is the next generation ground-based observatory for gamma-ray astronomy at very-high energies. Employing more than 100 (north and south sites) Imaging Atmospheric Cherenkov Telescopes in the northern and southern hemispheres, it was designed to reach unprecedented sensitivity and energy resolution. Understanding and correcting for systematic biases on the absolute energy scale and instrument response functions will be a cru- cial issue for the performance of CTA. The Montpellier group and the Spanish/Italian/Slovenian collaboration are currently building two Raman LIDAR prototypes for the online atmospheric cal- ibration along the line-of-sight of the CTA. Requirements for such a solution include the ability to characterize aerosol extinction at two wavelengths to distances up to 30 km with an accuracy better than 5%, within exposure time scales of about a minute, steering capabilities and close interaction with the CTA array control and data acquisition system as well as other auxiliary in- struments. Our Raman LIDARs have design features that make them different from those used in atmospheric science and are characterized by large collecting mirrors (∼2.5 m 2 ), liquid light- guides that collect the light at the focal plane and transport it to the readout system, reduced acquisition time and highly precise Raman spectrometers. The Raman LIDARs will participate in a cross-calibration and characterization campaign of the atmosphere at the CTA North site at La Palma, together with other site characterization instruments. After a one-year test period there, an in-depth evaluation of the solutions adopted by the two projects will lead to a final Raman LIDAR design proposal for both CTA sites.
Ključne besede: Raman lidar atmospheric calibration Cherenkov Telescope Array
Objavljeno: 29.08.2019; Ogledov: 102; Prenosov: 2
.pdf Polno besedilo (1,29 MB)

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Analysis of 19 Minerals and Cortisol in Red Deer Hair in Two Di erent Areas of the Stelvio National Park: A Preliminary Study
Marta Montillo, Tanja Peric, 2019, izvirni znanstveni članek

Opis: The aim of the study was to perform an investigation on the concentration of 19 minerals and cortisol in red deer (Cervus elaphus) hair, a matrix that is easy to collect with non-invasive and painless sampling, able to represent an integrative values of long-term substance concentrations, and able to give useful information, also when performed on dead animals, given its extreme stability over time. In the study thirty-five animals were included, coming from two di erent sides of a valley in the Stelvio National Park, where ocial water analysis had pointed out elevated concentrations of As in one of the two orographic sides. Hair cortisol concentrations were measured using a RIA(Radio Immuno Assay), while minerals were detected using ICP-MS (Inductively Coupled Plasma- Mass Spectrometry). Results showed a negative relationship between cortisol and some mineral concentrations (Li, Co, As, Cd, Cr and Tl) and significant di erences in some mineral concentrations between park areas (Al, Co, Cu, Cd and Ni). As, Cr and cortisol di erences approached statistical significance. This preliminary study represents a step forward in the study of wildlife allostatic load and a valid method for applications in wildlife management programs, in environmental studies and in public health programs.
Ključne besede: hair, deer, mineral, cortisol
Objavljeno: 27.08.2019; Ogledov: 71; Prenosov: 2
.pdf Polno besedilo (2,10 MB)

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The Multifaceted Complexity of Genetic Diseases: A Lesson from Pseudoxanthoma Elasticum
Ivonne Pasquali Ronchetti, Giulia Annovi, Federica Boraldi, Daniela Quaglino, 2011, samostojni znanstveni sestavek ali poglavje v monografski publikaciji

Ključne besede: Genetic pathology, skin, morphology, PXE
Objavljeno: 23.08.2019; Ogledov: 134; Prenosov: 0
.pdf Polno besedilo (23,60 MB)

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Recovery of bioactive components from fruit processing wastes
Branka Mozetič Vodopivec, 2019, objavljeni znanstveni prispevek na konferenci

Ključne besede: processing wastes, green extraction methods, polyphenols
Objavljeno: 23.08.2019; Ogledov: 118; Prenosov: 0
.pdf Polno besedilo (616,59 KB)
Gradivo ima več datotek! Več...

26.
Nanobodies: How to Exploit Pre-Immune Libraries and Recombinant Antibody Fragments
Ario De Marco, vabljeno predavanje na konferenci brez natisa

Ključne besede: nanobodies, in vitro panning, phage display
Objavljeno: 23.08.2019; Ogledov: 120; Prenosov: 0
.pdf Polno besedilo (188,41 KB)

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Fibroblast involvement in soft connective tissue calcification
Paolo Cianciulli, Giulia Annovi, Federica Boraldi, Ivonne Pasquali Ronchetti, Daniela Quaglino, 2013, pregledni znanstveni članek

Opis: Soft connective tissue calcification is not a passive process, but the consequence of metabolic changes of local mesenchymal cells that, depending on both genetic and environmental factors, alter the balance between pro- and anti-calcifying pathways. While the role of smooth muscle cells and pericytes in ectopic calcifications has been widely investigated, the involvement of fibroblasts is still elusive. Fibroblasts isolated from the dermis of pseudoxanthoma elasticum (PXE) patients and of patients exhibiting PXE-like clinical and histopathological findings offer an attractive model to investigate the mechanisms leading to the precipitation of mineral deposits within elastic fibers and to explore the influence of the genetic background and of the extracellular environment on fibroblast-associated calcifications, thus improving the knowledge on the role of mesenchymal cells on pathologic mineralization.
Ključne besede: fibroblasts, PXE, PXE-likedisorders, elastin, extracellularmatrix, ectopiccalcification, mesenchymal stromalcells
Objavljeno: 23.08.2019; Ogledov: 112; Prenosov: 0
.pdf Polno besedilo (1,31 MB)

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Heparan Sulfate Affects Elastin Deposition in Fibroblasts Cultured from Donors of Different Ages
Bruna Parma, Roberta Tiozzo, Deanna Guerra, Pasquale Moscarelli, Federica Boraldi, Giulia Annovi, Pascal Sommer, Daniela Quaglino, 2012, izvirni znanstveni članek

Opis: Heparan sulfate (HS), due to its presence on the cell surface and in the extracellular milieu and its ability to modulate cell signaling, has a fundamental role in both physiological and pathological conditions. For decades we have demonstrated the occurrence of interactions between glycosaminoglycans (GAGs) and elastic fibers. In particular, we have recently shown that HS is present inside elastic fibers and plays a role in the assembly and stability of elastin coacervates. Elastin represents, within the extracellular matrix, the component most severely affected during aging, and changes in the synthesis and posttranslational modifications of HS have been described, possibly influencing cellular behavior and protein interactions. Thus, the present study has investigated, in two different in vitro experimental models, the role of HS on elastin deposition and assembly. Results demonstrate that: (1) Biological effects of HS are partly dependent on the physicochemical characteristics of the GAGs; (2) HS does not affect attachment, viability, and growth of human dermal fibroblasts; (3) HS does not modify elastin gene expression nor elastin synthesis, but favors a-elastin aggregation and, independently from the age of donors, elastin assembly; (4) HS significantly increases the expression of fibulin 5, and these effects are especially evident in fibroblasts isolated from aging donors. These data provide a better understanding of the biological role of HS and offer new perspectives regarding the possibility of restoring and/or preserving the elastic component with aging.
Ključne besede: Heparan sulfate, Elastin, Fibroblasts
Objavljeno: 23.08.2019; Ogledov: 66; Prenosov: 0
.pdf Polno besedilo (1,51 MB)

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