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New insights into autophagic cell death in the gypsy moth Lymantria dispar: a proteomic approach.
Enzo Ottaviani, Daniela Quaglino, Giulia Annovi, Federica Boraldi, Davide Malagoli, 2009, izvirni znanstveni članek

Opis: Autophagy is an evolutionary ancient process based on the activity of genes conserved from yeast to metazoan taxa. Whereas its role as a mechanism to provide energy during cell starvation is commonly accepted, debate continues about the occurrence of autophagy as a means specifically activated to achieve cell death. The IPLB-LdFB insect cell line, derived from the larval fat body of the lepidoptera Lymantria dispar, represents a suitable model to address this question, as both autophagic and apoptotic cell death can be induced by various stimuli. Using morphological and functional approaches, we have observed that the culture medium conditioned by IPLB-LdFB cells committed to death by the ATPase inhibitor oligomycin A stimulates autophagic cell death in untreated IPLB-LdFB cells. Moreover, proteomic analysis of the conditioned media suggests that, in IPLB-LdFB cells, oligomycin A promotes a shift towards lipid metabolism, increases oxidative stress and specifically directs the cells towards autophagic activity.
Ključne besede: Autophagic cell death, Fat body, IDGF, IPLB-LdFB, Proteomics
Objavljeno: 23.08.2019; Ogledov: 99; Prenosov: 0
.pdf Polno besedilo (2,33 MB)

A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing.
Serafina Battistelli, Beatrice Baldelli, Giulia Annovi, Federica Boraldi, Manuela Malatesta, Marco Baggiogera, Daniela Quaglino, 2008, izvirni znanstveni članek

Opis: Liver represents a suitable model for monitoring the effects of a diet, due to its key role in controlling the whole metabolism. Although no direct evidence has been reported so far that genetically modified (GM) food may affect health, previous studies on hepatocytes from young female mice fed on GM soybean demonstrated nuclear modifications involving transcription and splicing pathways. In this study, the effects of this diet were studied on liver of old female mice in order to elucidate possible interference with ageing. The morpho-functional characteristics of the liver of 24-month-old mice, fed from weaning on control or GM soybean, were investigated by combining a proteomic approach with ultrastructural, morphometrical and immunoelectron microscopical analyses. Several proteins belonging to hepatocyte metabolism, stress response, calcium signalling and mitochondria were differentially expressed in GM-fed mice, indicating a more marked expression of senescence markers in comparison to controls. Moreover, hepatocytes of GM-fed mice showed mitochondrial and nuclear modifications indicative of reduced metabolic rate. This study demonstrates that GM soybean intake can influence some liver features during ageing and, although the mechanisms remain unknown, underlines the importance to investigate the long-term consequences of GM-diets and the potential synergistic effects with ageing, xenobiotics and/or stress conditions.
Ključne besede: Genetically modified soybean, liver, mitochondria
Objavljeno: 23.08.2019; Ogledov: 93; Prenosov: 0
.pdf Polno besedilo (514,70 KB)

Matjaž Valant, 2019, izvirni znanstveni članek

Ključne besede: kanabidiol, CBD, nanodelci, metoda obarjanja
Objavljeno: 14.08.2019; Ogledov: 191; Prenosov: 0
.pdf Polno besedilo (860,67 KB)

Advanced applications of amorphous alumina: From nano to bulk
Matjaz Valant, Boštjan Mavrič, 2019, pregledni znanstveni članek

Ključne besede: amorfni oksidi, funkcionalne lastnosti površin, amorfna struktura
Objavljeno: 12.08.2019; Ogledov: 190; Prenosov: 0
.pdf Polno besedilo (4,40 MB)

Weak embeddable hypernear-rings
Jelena Dakić, Sanja Jančić-Rašović, Irina Cristea, 2019, izvirni znanstveni članek

Ključne besede: hypernear-ring, multitransformation, embedding
Objavljeno: 07.08.2019; Ogledov: 213; Prenosov: 7
.pdf Polno besedilo (248,69 KB)

A robotic pipeline for fast GRB followup with the Las Cumbrés observatory network
Andreja Gomboc, 2019, izvirni znanstveni članek

Ključne besede: izbruhi sevanja gama, teleskopi, mreža teleskopov
Objavljeno: 31.07.2019; Ogledov: 267; Prenosov: 0
.pdf Polno besedilo (2,44 MB)

Editorial: Scalar Implicatures
Anne Reboul, Penka Stateva, 2019, kratki znanstveni prispevek

Opis: In 1975, Grice introduced the notion of implicature, arguing that it was more appropriate to account for a class of apparent lexical ambiguities through pragmatic processes than by multiplying lexical meanings (Modified Ockham's razor: Do not multiply meanings beyond necessity; Grice, 1975). For the past 20 years, experimental approaches have superseded purely theoretical ones, with mixed results. Paradigms using verification tasks on infelicitous sentences, with rate of pragmatic answers and reaction time as measures, have generally concluded in favor of the post-Gricean views (Bott and Noveck, 2004; Noveck and Reboul, 2008). However, some recent studies discuss additional factors affecting implicature processing and have introduced new paradigms which suggest a different conclusion (Katsos and Bishop, 2011; Breheny et al., 2013; Degen and Tanenhaus, 2015; Foppolo and Marelli, 2017; Bill et al.; Jasbi et al.; Sikos et al.). In addition, current research has shown that lexical scales may play a role in the process in keeping with neo-Gricean views. This Frontiers topic is a collection of 12 contributions in experimental pragmatics focusing on different aspects of child and adult processing of implicatures, factors affecting their rate, relevance of testing paradigms, scale diversity, cross-linguistic differences, and variation in triggers.
Ključne besede: scalar implicature, experimental pragmatics, neo-Gricean pragmatics, post-Gricean pragmatics, grammatical theory of implicatures
Objavljeno: 31.07.2019; Ogledov: 283; Prenosov: 7
.pdf Polno besedilo (181,24 KB)

БІОХІМІЯ: Методичні вказівки до виконання лабораторних робіт для студентів напрямів підготовки «Хімія», «Біологія» денної та заочної форм навчання Вінниця ДонНУ
Ганна Степаненко, Олена Душенко, Юлія Лесишина, 2016, drugo učno gradivo

Opis: Навчальне видання рекомендоване студентам, що навчаються за напрямами підготовки «Хімія», «Біологія» денної та заочної форм навчання, для виконання лабораторних робіт з дисципліни «Біохімія». Методичні вказівки включають назви лабораторних робіт, порядок виконання робіт, контрольні питання для закріплення матеріалу з теми, список рекомен-дованої літератури.
Ključne besede: методичні вказівки, біохімія
Objavljeno: 30.07.2019; Ogledov: 198; Prenosov: 0
.pdf Polno besedilo (960,90 KB)

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