3301. Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailtyNicholas Rattray, Drupad Trivedi, Yun Xu, Tarani Chandola, Caroline Johnson, Alan Marshall, Krisztina Mekli, Zahra Rattray, Gindo Tampubolon, Bram Vanhoutte, Iain R. White, Frederick Wu, Neil Pendleton, James Nazroo, Royston Goodacre, 2019, izvirni znanstveni članek Opis: Global ageing poses a substantial economic burden on health and social care costs. Enabling a greater proportion of older people to stay healthy for longer is key to the future sustainability of health, social and economic policy. Frailty and associated decrease in resilience plays a central role in poor health in later life. In this study, we present a population level assessment of the metabolic phenotype associated with frailty. Analysis of serum from 1191 older individuals (aged between 56 and 84 years old) and subsequent longitudinal validation (on 786 subjects) was carried out using liquid and gas chromatography-mass spectrometry metabolomics and stratified across a frailty index designed to quantitatively summarize vulnerability. Through multivariate regression and network modelling and mROC modeling we identified 12 significant metabolites (including three tocotrienols and six carnitines) that differentiate frail and non-frail phenotypes. Our study provides evidence that the dysregulation of carnitine shuttle and vitamin E pathways play a role in the risk of frailty.
Ključne besede: metabolomics, frailty, ageing, LC-MS, serum
Objavljeno v RUNG: 08.11.2019; Ogledov: 3304; Prenosov: 90
 Celotno besedilo (2,35 MB) |
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3305. Scalar Implicaturesznanstvena monografija Opis: Scalar implicatures have enjoyed the status of one of the most researched topics in both theoretical and experimental pragmatics in recent years. This Research Topic presents new developments in studying the comprehension, as well as the production of scalar inferences, suggests new testing paradigms that trigger important discussions about the methodology of experimental investigation, explores the effect of prosody and context on inference rates. To a great extent the articles reflect the state of the art in the domain and outline promising paths for future research.
Ključne besede: Scalar implicature, Lexical scales, Scalar variability, Cross-linguistic variation, Production, Comprehension, Prosody, Context
Objavljeno v RUNG: 06.11.2019; Ogledov: 3202; Prenosov: 116
Celotno besedilo (15,33 MB) |
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3307. On the nature of prenumeral adjectivesFranc Marušič, Rok Žaucer, 2019, objavljeni znanstveni prispevek na konferenci (vabljeno predavanje) Opis: Following Greenberg’s generalization 20 prenominal adjectives follow numerals. In
this paper we discuss a group of adjectives that appear in unexpected positions: adjectives
preceding numerals prenominally. We argue that these adjectives violate cross-linguistic
generalizations only apparently, as the noun phrases with such adjectives actually contain
additional covert structure – structure that is not realized phonologically/phonetically.
Ključne besede: Greenberg’s generalization 20, adjectives, numerals, noun phrase, Slovenian syntax
Objavljeno v RUNG: 05.11.2019; Ogledov: 2725; Prenosov: 0
Gradivo ima več datotek! Več... |
3308. Tvorbeno jezikoslovje o slovenščiniFranc Marušič, Petra Mišmaš, Rok Žaucer, druga izvedena dela Opis: Tvorbeno jezikoslovje je nastalo v petdesetih letih prejšnjega stoletja in se hitro razširilo po Severni Ameriki in drugod po svetu. Spodbudilo je tudi nastanek številnih variacij osnovne ideje ter tudi tako pripomoglo k prepoznavnosti splošnega jezikoslovja. V Sloveniji je bilo tvorbeno jezikoslovje dolgo časa obrobno, četudi smo imeli s tvorbenim jezikoslovje stik že vsaj od šestdesetih let. V zadnjih letih je število tvorbenih objav o slovenščini skokovito naraslo, zaradi česar se zdi primerno narediti pregled nekaj najodmevnejših objav, ki vključujejo slovenske podatke.
Ključne besede: jezikoslovje, tvorbeno jezikoslovje, slovenščina, skladnja, pregled
Objavljeno v RUNG: 04.11.2019; Ogledov: 2677; Prenosov: 0
Gradivo ima več datotek! Več... |
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