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1.
Sustained delivery of Cu(II)-based DNA intercalators by nanometer-sized cyclodextrin-based porous polymers
Tina Škorjanc, Julian Heinrich, Damjan Makuc, Nora Kulak, Matjaž Valant, 2023, izvirni znanstveni članek

Opis: DNA intercalators are small molecules that insert between adjacent DNA base pairs and thus disturb DNA replication and transcription, which can lead to cell death. Certain metal complexes are excellent DNA intercalators, and have shown promise in chemotherapy. Here, a cyclodextrin porous polymer was prepared, characterized, exfoliated to form nanometer-sized particles, and used as a delivery vehicle for metal-free and Cu(II)-metalated anthraquinone-based DNA intercalators with a goal to minimize side effects of the highly toxic DNA intercalators. NMR experiments, including DOSY NMR, have shown the interaction between the cyclodextrin building block and the studied DNA intercalators. Porous nature of the delivery vehicle provided ample surface area for interaction with the drug candidates, resulting in encapsulation rates of up to 56%. Sustained cargo release from the polymer was achieved over eight days, and time-dependent cytotoxicity was observed. Furthermore, optical microscopy images indicated delivery vehicle internalization as well as disturbed cellular morphology within 24 hours of incubation. We anticipate that this study will stimulate further interest in the development of polymeric delivery systems for metal complexes.
Ključne besede: porous organic polymers, cyclodextrin, DNA intercalators, Cu(II) complexes, metal complexes
Objavljeno v RUNG: 10.11.2023; Ogledov: 512; Prenosov: 4
.pdf Celotno besedilo (5,10 MB)
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2.
A rational design of isoindigo-based conjugated microporous n-type semiconductors for high electron mobility and conductivity
Kayaramkodath C. Ranjeesh, Ayman Rezk, Jose Ignacio Martinez, Safa Gaber, Areej Merhi, Tina Škorjanc, Matjaž Finšgar, Gisha Elizabeth Luckachan, Ali Trabolsi, Bilal R. Kaafarani, 2023, izvirni znanstveni članek

Opis: The development of n-type organic semiconductors has evolved significantly slower in comparison to that of p-type organic semiconductors mainly due to the lack of electron-deficient building blocks with stability and processability. However, to realize a variety of organic optoelectronic devices, high-performance n-type polymer semiconductors are essential. Herein, conjugated microporous polymers (CMPs) comprising isoindigo acceptor units linked to benzene or pyrene donor units (BI and PI) showing n-type semiconducting behavior are reported. In addition, considering the challenges of deposition of a continuous and homogeneous thin film of CMPs for accurate Hall measurements, a plasma-assisted fabrication technique is developed to yield uniform thin films. The fully conjugated 2D networks in PI- and BI-CMP films display high electron mobility of 6.6 and 3.5 cm2 V−1 s−1, respectively. The higher carrier concentration in PI results in high conductivity (5.3 mS cm−1). Both experimental and computational studies are adequately combined to investigate structure–property relations for this intriguing class of materials in the context of organic electronics.
Ključne besede: conjugated microporous polymers, isoindigo, semiconductors, conductivity, electron mobility
Objavljeno v RUNG: 18.08.2023; Ogledov: 676; Prenosov: 7
.pdf Celotno besedilo (2,08 MB)
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3.
Biological applications of porous polymers and covalent organic frameworks : lecture at the Otto-von-Guericke Universität Magdeburg, Tuesday, 27th June 2023, Magdeburg, Germany
Tina Škorjanc, 2023, prispevek na konferenci brez natisa

Opis: Porous organic polymers (POPs) and covalent organic frameworks (COFs) have gained significant attention in the scientific community for a wide array of applications because of their attractive physical and chemical properties. Porosity of these materials provides ample surface area for interaction with targets, while crystallinity allows for highly specific structural tuning. In this seminar, I will present two strategies of utilizing these features of newly prepared materials in biosensing. Firstly, a cationic POP was synthesized, deposited onto interdigitated electrode arrays via a nontraditional electrophoresis technique, and utilized for electrochemical sensing of bacterial cells. As the principle of detection relied on electrostatic interactions between the cationic POP and the anionic bacterial surface, the sensor operated for both Gram-positive and Gram-negative bacteria. Secondly, a small-molecule nitroimidazole target for hypoxia, a low oxygen environment present in tumors, was post-synthetically conjugated to the pores of a fluorescent COF. This material served as a useful hypoxia imaging agent in cancerous cells. The seminar will conclude with some future perspectives on POPs and COFs in biological applications followed by Q & A.
Ključne besede: Porous organic polymers, covalent organic frameworks, biosensors, hypoxia
Objavljeno v RUNG: 13.07.2023; Ogledov: 707; Prenosov: 0
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Photoexcited charge mobility in quasi two-dimensional polyacetylene
Nadiia Pastukhova, Kejun Liu, Renhao Dong, Gvido Bratina, Xinliang Feng, Egon Pavlica, 2022, objavljeni povzetek znanstvenega prispevka na konferenci

Opis: Two-dimensional conjugated polymers (2DCPs) have been described and recognised as crystalline, one- to two-layer polymer nanosheets prepared by 2D covalent polymerization exhibiting strong in-plane π-electron delocalization with two orthogonal directions and weak out-of-plane π-π stacking.[1,2] The extension of polymer dimensionality into two dimensions improves the alignment of individual polymer sheets and overcomes the limitations associated with charge carrier hopping between polymer chains in one-dimensional and crosslinked polymers.[3] Compared to other two-dimensional materials such as graphene or transition metal dichalcogenides, 2DCPs offer a high degree of flexibility in chemical design and are compatible with liquid-based processing methods. Various 2DCPs have been synthesised by surfactant monolayer-assisted interfacial synthesis (SMAIS).[5] Of particular interest is the photoresponse of these materials due to their tunable properties, such as bandgap and associated wavelength-dependent photoexcitation, which enables a wide range of applications in optoelectronic devices. Using time-of-flight photoconductivity (TOF-PC) measurements [4], we investigate the charge transport properties of 2D polyacetylene prepared by SMAIS method. We preform TOF-PC measurement of 2D polyacetylene using a focused nanosecond pulse laser at 325 nm and electrode separation of 250 µm. From the bias polarity and time duration of the photocurrent, we can determine the polarity, velocity and mobility of photoexcited charge carriers as a function of applied bias voltage and excitation wavelength. Using excitation at 325 m, we observed an electron mobility in the range of 150 cm2 V-1 s-1, which is in the realm of most advances small-molecule single-crystal organic semiconductors and almost an order of magnitude higher than linear polymeric semiconductors.
Ključne besede: Two-dimensional conjugated polymers, 2DCPs, 2Dpolymers, charge mobility, time-of-flight photoconductivity
Objavljeno v RUNG: 29.11.2022; Ogledov: 914; Prenosov: 0
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Pulling polymers : models and experiment
Knarik Yeritsyan, 2021, druge monografije in druga zaključena dela

Ključne besede: polymers, DNA pulling, worm-like chain
Objavljeno v RUNG: 19.08.2021; Ogledov: 1569; Prenosov: 47
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10.
Polymer-based nano-composites for thermal insulation
Alessandro Fraleoni-Morgera, Manisha Chhikara, 2019, pregledni znanstveni članek

Ključne besede: nano-composites, polymers, thermal insulation
Objavljeno v RUNG: 13.07.2021; Ogledov: 1962; Prenosov: 0

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