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Studying TDEs in the era of LSST
Katja Bricman, Andreja Gomboc, 2019, objavljeni povzetek znanstvenega prispevka na konferenci

Ključne besede: The observing strategy with continuous scanning and large sky coverage of the upcoming ground-based Large Synoptic Survey Telescope (LSST) will make it a perfect tool in search of rare transients, such as Tidal Disruption Events (TDEs). Bright optical flares resulting from tidal disruption of stars by their host supermassive black hole (SMBH) can provide us with important information about the mass of the SMBH involved in the disruption and thus enable the study of quiescent SMBHs, which represent a large majority of SMBHs found in centres of galaxies. These types of transients are extremely rare, with only about few tens of candidates discovered so far. It is expected that the LSST will provide a large sample of new TDE light curves. Here we present simulations of TDE observations using an end-to-end LSST simulation framework. Based on the analysis of simulated light curves we estimate the number of TDEs with good quality light curves the LSST is expected to discover in 10 years of observations. In addition, we investigate whether TDEs observed by the LSST could be used to probe the SMBH mass distribution in the universe. The participation at this conference is supported by the Action CA16104 Gravitational waves, black holes and fundamental physics (GWverse), supported by COST (European Cooperation in Science and Technology).
Objavljeno v RUNG: 04.01.2021; Ogledov: 2533; Prenosov: 0

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Advantages and disadvantages of experiments with ultrashort two-color pulses
Matija Stupar, 2020, doktorska disertacija

Opis: Advances in the development of lasers have led to a new class of radiation sources generating coherent, tunable, ultrashort light pulses in the spectral region ranging from infrared to soft X-rays. This includes high-order harmonics generation in gas (HHG), on which relies the CITIUS facility at University of Nova Gorica (Slovenia), and free-electron lasers (FELs), such as the facility FERMI at Elettra-Sincrotrone Trieste (Italy). The distinctive structure of HHG and FEL radiation paved the way to time-resolved experiments, which are performed to investigate events occurring on a short, or very short, temporal scale, from picoseconds to femtoseconds. This work focuses on the advantages and disadvantages of some experimental techniques based on using these novel light sources to investigate the microscopic and/or ultrafast dynamics of matter samples, which have been previously driven out of equilibrium. Advantages rely on the implementation of various applications based on two-color schemes and, more specifically, include the possibility of acquiring two-dimensional frequency maps, measuring electrons’ effective masses, or investigating electronic properties decoupled from the influence of the lattice. Particular focus will be put on experimental methods relying on photoelectric effect and photoelectron spectroscopy. In all experiments, we took advantage of one or more specific properties of HHG and FEL sources, such as controllable chirp, to study laser dressed states in helium, variable polarization, to study electronic properties of iron-based pnictides and ultrashort pulses (< 10 fs) to study the purely electronic dynamics in transition metal dichalcogenides. On the other hand, the study of the interface between a molecule and a topological insulator revealed some intrinsic limitations and physical drawbacks of the technique, such as spurious effects originating from the high power pulses, like multiphoton absorption and the space charge effect, or the reduction of experimental resolution when pushing for shorter and shorter pulse durations. Some disadvantages are also connected to the current state-of-the-art in the field of ultrashort laser systems, where a trade-off needs to be found between repetition rate and laser power. Finally, state-of-the-art experiments based on the ability to generate ultrashort pulses carrying orbital angular momentum in visible, near-infrared as well as extreme UV range will be presented. The use of these pulses opens the door to the investigation of new physical phenomena, such as probing magnetic vortices using extreme ultraviolet light from a free-electron laser or imprinting the spatial distribution of an ultrashort infrared pulse carrying orbital angular momentum onto a photoelectron wave packet.
Ključne besede: ultrafast lasers, two-color experiments, photoemission, high-order harmonic generation, free-electron lasers, hot-electrons dynamics, surface science, pump-probe photoemission, ultraviolet photoemission, orbital angular momentum
Objavljeno v RUNG: 02.12.2020; Ogledov: 3655; Prenosov: 112
.pdf Celotno besedilo (19,78 MB)

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In silico generation of peptides by replica exchange Monte Carlo: Docking-based optimization of maltose-binding-protein ligands
Anna Russo, Pasqualina Liana Scognamiglio, Rolando Pablo Hong Enriquez, Carlo Santambrogio, Rita Grandori, Daniela Marasco, Antonio Giordano, Giacinto Scoles, Sara Fortuna, 2015, izvirni znanstveni članek

Opis: Short peptides can be designed in silico and synthesized through automated techniques, making them advantageous and versatile protein binders. A number of docking-based algorithms allow for a computational screening of peptides as binders. Here we developed ex-novo peptides targeting the maltose site of the Maltose Binding Protein, the prototypical system for the study of protein ligand recognition. We used a Monte Carlo based protocol, to computationally evolve a set of octapeptides starting from a polialanine sequence. We screened in silico the candidate peptides and characterized their binding abilities by surface plasmon resonance, fluorescence and electrospray ionization mass spectrometry assays. These experiments showed the designed binders to recognize their target with micromolar affinity. We finally discuss the obtained results in the light of further improvement in the ex-novo optimization of peptide based binders.
Ključne besede: peptides, docking, optimisation, computation, maltose binding protein, probe, ligand
Objavljeno v RUNG: 12.10.2016; Ogledov: 3921; Prenosov: 140
.pdf Celotno besedilo (4,27 MB)

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