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Title:Cardiac stem cell aging and heart failure
Authors:Cesselli, Daniela (Author)
Aleksova, Aneta (Author)
Mazzega, Elisa (Author)
Caragnano, Angela (Author)
Beltrami, Antonio Paolo (Author)
Files:This document has no files. This document may have a phisical copy in the library of the organization, check the status via COBISS. Link is opened in a new window
Language:English
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:UNG - University of Nova Gorica
Abstract:A side effect of the medical improvements of the last centuries is the progressive aging of the world population, which is estimated to reach the impressive number of 2 billion people with more than 65 years by 2050. As a consequence, age-related diseases, such as heart failure, will affect more and more patients in the next years. To understand the biological bases of these diseases will be a crucial task in order to find better treatments, and possibly slow age-related morbidity and mortality. Cardiac stem cells have been at the center of a heated debate and their potential involvement in cardiac homeostasis has been questioned. In this review, we summarize evidence obtained by independent groups, on different animal models and humans, that strongly support the important role played by immature, cardiac resident cells in the cardioprotection against heart failure.
Keywords:Aging, Heart failure, Cardiomyocyte turnover, Stem cells, Cell senescence, cKit, Sca1, PDGFRα, Cardiospheres
Year of publishing:2017
Number of pages:7
Numbering:XXX
COBISS_ID:4759291  Link is opened in a new window
URN:URN:SI:UNG:REP:P7XRQDSR
DOI:10.1016/j.phrs.2017.01.013 Link is opened in a new window
License:CC BY-NC-ND 4.0
This work is available under this license: Creative Commons Attribution Non-Commercial No Derivatives 4.0 International
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Record is a part of a journal

Title:Pharmacological Research
Publisher:Elsevier
ISSN:1043-6618
Year of publishing:2017

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