Repozitorij Univerze v Novi Gorici

Izpis gradiva
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Naslov:Nanobody technology: principles & applications
Avtorji:De Marco, Ario (Avtor)
Datoteke:Gradivo nima datotek. Gradivo je morda fizično dosegljivo v knjižnici fakultete, zalogo lahko preverite v COBISS-u. Povezava se odpre v novem oknu
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:3.14 - Predavanje na tuji univerzi
Organizacija:UNG - Univerza v Novi Gorici
Opis:Antibodies possess unattainable capacity to bind selectively and at high affinity their cognates. For this reason they have been largely used in applications which rely on specific molecular recognition. Biosensors, nanoparticles, and even cells can be functionalized with antibodies for improving sensitivity and target specificity. However, conventional antibodies (IgGs) are large molecules (150 kDa) that are difficult to engineer. In the last years, antibody fragments have become more and more popular as an effective alternative and specifically nanobodies raised enthusiasm because of their minimal mass (14 kDa), high stability, relative similarity to human sequences, and simplified mutagenesis. Pre-immune nanobody libraries have the further advantage of enabling blind selection for antigens that can be used to discriminate between subpopulations of cells and vesicles. The panning can be performed directly on intact cells and the resulting binders are specific for the native antigen conformation
Ključne besede:Nanobodies, in vitro panning, cancer biomarkers, recombinant antibody engineering
Leto izvedbe:2017
Kraj izvedbe:University of Gent
COBISS_ID:4775675 Povezava se odpre v novem oknu
URN:URN:SI:UNG:REP:Q2FGGR23
Število ogledov:1696
Število prenosov:0
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Gradivo ni uvrščeno v področja.
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Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.

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Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Program financ.:Sofinanciranje znanstvenoraziskovalnega sodelovanja med RS in Flamsko skupnostjo ter Flamsko regijo
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