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Title:DEHYDROEPIANDROSTERONE SULFATE CLAWS CONCENTRATIONS IN DOGS FROM BIRTH TO 30 DAYS OF AGE: PRELIMINARY RESULTS.
Authors:Peric, Tanja (Authorship owner)
Fusi, Jasmine (Author)
Montillo, Marta (Author)
Bolis, Barbara (Author)
Rota, Alessandro (Author)
Peric, Tanja (Author)
Veronesi, Maria Cristina (Author)
Files:This document has no files. This document may have a phisical copy in the library of the organization, check the status via COBISS. Link is opened in a new window
Language:English
Work type:Not categorized (r6)
Tipology:1.12 - Published Scientific Conference Contribution Abstract
Organization:UNG - University of Nova Gorica
Abstract:Similarly to all other species, also in the dog improvements in the knowledge on perinatology are mandatory for a better management of newborns, mainly aimed to reduce the impact of perinatal mortality. However, until recently, the study of canine perinatology was limited mainly because of the invasiveness of many investigation procedures, such as repeated blood sampling. In recent times, the claws/nails were proved to be a useful, non invasive, matrix for long time-frame retrospective hormone concentrations analysis also in babies and puppies [1,2], providing a suitable matrix for perinatal long-term hormonal changes studies. The last intrauterine foetal stage of development and the neonatal period represent the most challenging phases for the mammals offspring. It was demonstrated that the activation of the fetal hypothalamic-pituitary-adrenal (HPA) axis leads to dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) secretion, the major fetal steroids. Thus, DHEA-S measured at birth in newborns could be considered as a marker of offspring HPA axis activity, under the maternal influence. This study was aimed to assess the DHEA-S concentrations in newborn puppies claws, collected at birth and at 30 days of age, and to evaluate the possible influence of age, gender and type of birth on DHEA-S claws accumulation. The study was performed on 58 large purebred, normal, healthy, viable (Apgar≥7) puppies, 31 males and 27 females, born by vaginal spontaneous (N=22) or caesarean (N=36) parturition. DHEA-S was analysed by RIA. The mean ± SD DHEA-S claws concentration significantly (p<0.01) decreased from birth (210±152.00 pg/mg) to 30 days (91±72.63 pg/mg), evidencing the higher fetal DHEA-S secretion in the last fetal stage of pregnancy in comparison to the first postnatal month of age. According to the type of parturition, higher (p<0.001) DHEA-S claws concentrations were found at birth in puppies born by spontaneous than caesarean parturition (300±167.05 vs 154±112.23 pg/mg, respectively); this finding deserves further investigations. No influence of newborn gender was found. Claws DHEA-S values at birth were a bit higher, but with a lower SD, in comparison to data reported for babies 1-3 weeks old [1]. The trend of decrease is in agreement with data reported for cortisol [2] in dead puppies, and suggests, beside the role of cortisol, the important effects of DHEA-S around the time of birth, also in puppies, as reported for babies [1]. [1] Tegethoff et al. Dehydroepindrosterone in nails of infants: a potential biomarker of intrauterine responses to maternal stress. Biological psychology, 87: 414-420, 2011. [2] Veronesi et al. Coat and claws as new matrices for noninvasive long-term cortisol assessment in dogs from birth up to 30 days of age. Theriogenology, 84: 791-796, 2015.
Keywords:DHEA-S, claw, dog
Year of publishing:2017
Number of pages:1
COBISS_ID:4878331  Link is opened in a new window
URN:URN:SI:UNG:REP:VVZUKWOC
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Record is a part of a monograph

Title:Atti del 71° Convegno Sisvet 2017
Publisher:Società Italiana delle Scienze Veterinarie
Conference organizer:Società Italiana delle Scienze Veterinarie
ISBN:9788890909245
Place of publishing:Napoli
Year of publishing:2017

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