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Title:Real-time multi-marker measurement of organic compounds in human breath: Towards fingerprinting breath
Authors:White, Iain R (Author)
Willis, Kerry A (Author)
Whyte, Christopher (Author)
Cordell, Rebecca (Author)
Blake, Robert S (Author)
Wardlaw, Andrew J (Author)
Files:This document has no files. This document may have a phisical copy in the library of the organization, check the status via COBISS. Link is opened in a new window
Language:English
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:The prospects for exploiting proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) in medical diagnostics are illustrated through a series of case studies. Measurements of acetone levels in the breath of 68 healthy people are presented along with a longitudinal study of a single person over a period of 1 month. The median acetone concentration across the population was 484 ppbV with a geometric standard deviation (GSD) of 1.6, whilst the average GSD during the single subject longtitudinal study was 1.5. An additional case study is presented which highlights the potential of PTR-ToF-MS in pharmacokinetic studies, based upon the analysis of online breath samples of a person following the consumption of ethanol. PTR-ToF-MS comes into its own when information across a wide mass range is required, particularly when such information must be gathered in a short time during a breathing cycle. To illustrate this property, multicomponent breath analysis in a small study of cystic fibrosis patients is detailed, which provides tentative evidence that online PTR-ToF-MS analysis of tidal breath can distinguish between active infection and non-infected patients.
Keywords:Volatile Organic Compounds, breath, proton transfer reaction mass spectrometry, Cystic Fibrosis
Year of publishing:2013
Number of pages:11
Numbering:7, 1
COBISS_ID:5423867 Link is opened in a new window
URN:URN:SI:UNG:REP:WRX9CNKR
DOI:10.1088/1752-7155/7/1/017112 Link is opened in a new window
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