Repozitorij Univerze v Novi Gorici

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Naslov:Matrix Gla protein (MGP) is involved in elastic fiber calcification in the dermis of Pseudoxanthoma Elasticum (PXE) patients.
Avtorji:Dealba, Gheduzzi (Avtor)
Boraldi, Federica (Avtor)
Giulia, Annovi (Avtor)
Chiara, Paolinelli Devincenzi (Avtor)
Leon J, Schurgers (Avtor)
Cees, Vermeer (Avtor)
Daniela, Quaglino (Avtor)
Ivonne, Pasquali Ronchetti (Avtor)
et al.
Datoteke:Gradivo nima datotek. Gradivo je morda fizično dosegljivo v knjižnici fakultete, zalogo lahko preverite v COBISS-u. Povezava se odpre v novem oknu
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Mature MGP (Matrix g-carboxyglutamic acid protein) is known to inhibit soft connective tissues calcification. We investigated its possible involvement in pseudoxanthoma elasticum (PXE), a genetic disorder whose clinical manifestations are due to mineralization of elastic fibers. PXE patients have lower serum concentration of total MGP compared to controls (Po0.001). Antibodies specific for the noncarboxylated (Glu-MGP) and for the g-carboxylated (Gla-MGP) forms of MGP were assayed on ultrathin sections of dermis from controls and PXE patients. Normal elastic fibers in controls and patients were slightly positive for both forms of MGP, whereas Gla-MGP was more abundant within control’s than within patient’s elastic fibers (Po0.001). In patients’ calcified elastic fibers, Glu-MGP intensively colocalized with mineral precipitates, whereas Gla-MGP precisely localized at the mineralization front. Data suggest that MGP is present within elastic fibers and is associated with calcification of dermal elastic fibers in PXE.
Ključne besede:calcification, dermal fibroblast, elastic fiber, human skin, MGP, pseudoxanthoma elasticum
Leto izida:2007
Št. strani:998-1008
Številčenje:87
COBISS_ID:5424635 Povezava se odpre v novem oknu
URN:URN:SI:UNG:REP:HP9EHLDU
Licenca:CC BY-NC-ND 4.0
To delo je dosegljivo pod licenco Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Število ogledov:207
Število prenosov:0
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Področja:Gradivo ni uvrščeno v področja.
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Gradivo je del revije

Naslov:Laboratory Investigation
Leto izida:2007

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