Repository of University of Nova Gorica

Show document
A+ | A- | SLO | ENG

Title:A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing.
Authors:Malatesta, Manuela (Author)
Boraldi, Federica (Author)
Annovi, Giulia (Author)
Baldelli, Beatrice (Author)
Battistelli, Serafina (Author)
Baggiogera, Marco (Author)
Quaglino, Daniela (Author)
Files:This document has no files. This document may have a phisical copy in the library of the organization, check the status via COBISS. Link is opened in a new window
Language:English
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:Liver represents a suitable model for monitoring the effects of a diet, due to its key role in controlling the whole metabolism. Although no direct evidence has been reported so far that genetically modified (GM) food may affect health, previous studies on hepatocytes from young female mice fed on GM soybean demonstrated nuclear modifications involving transcription and splicing pathways. In this study, the effects of this diet were studied on liver of old female mice in order to elucidate possible interference with ageing. The morpho-functional characteristics of the liver of 24-month-old mice, fed from weaning on control or GM soybean, were investigated by combining a proteomic approach with ultrastructural, morphometrical and immunoelectron microscopical analyses. Several proteins belonging to hepatocyte metabolism, stress response, calcium signalling and mitochondria were differentially expressed in GM-fed mice, indicating a more marked expression of senescence markers in comparison to controls. Moreover, hepatocytes of GM-fed mice showed mitochondrial and nuclear modifications indicative of reduced metabolic rate. This study demonstrates that GM soybean intake can influence some liver features during ageing and, although the mechanisms remain unknown, underlines the importance to investigate the long-term consequences of GM-diets and the potential synergistic effects with ageing, xenobiotics and/or stress conditions.
Keywords:Genetically modified soybean, liver, mitochondria
Year of publishing:2008
Number of pages:967-977
Numbering:130
COBISS_ID:5438971 Link is opened in a new window
URN:URN:SI:UNG:REP:CGFYYCW4
DOI:10.1007/s00418-008-0476-x Link is opened in a new window
License:CC BY-NC-ND 4.0
This work is available under this license: Creative Commons Attribution Non-Commercial No Derivatives 4.0 International
Views:525
Downloads:0
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Categories:Document is not linked to any category.
:
  
Average score:(0 votes)
Your score:Voting is allowed only for logged in users.

Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.

Record is a part of a journal

Title:Histochemical cellular biology
Shortened title:Histochem Cell Biol
Year of publishing:2008

Back