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Naslov:Comparison of ex vivo and in vitro human fibroblast ageing models.
Avtorji:ID Boraldi, Federica, Università di Modena e Reggio Emilia (Avtor)
ID Annovi, Giulia, Università di Modena e Reggio Emilia (Avtor)
ID Tiozzo, Roberta, Università di Modena e Reggio Emilia (Avtor)
ID Sommer, Pascal, Institut de Biologie et Chimie des Prote´ines, CNRS - Universite´ Lyon 1 ( (Avtor)
ID Quaglino, Daniela, Università di Modena e Reggio Emilia (Avtor)
Datoteke: Gradivo nima datotek, ki so prostodostopne za javnost. Gradivo je morda fizično dosegljivo v knjižnici fakultete, zalogo lahko preverite v COBISS-u. Povezava se odpre v novem oknu
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Several studies have analyzed modulation of gene expression during physiological ageing with interesting, but often contradictory results, depending on the model used. In the present report we compare age-related metabolic and synthetic parameters in human dermal fibroblasts (HDF) isolated from young and old subjects (ex vivo ageing model) and cultured from early up to late cumulative population doublings (CPD) (in vitro ageing model) in order to distinguish changes induced in vivo by the aged environment and maintained in vitro, from those associated with cell senescence and progressive CPD. Results demonstrate that fibroblasts from aged donors, already at early CPD, exhibit an impaired redox balance, highlighting the importance of this parameter during ageing, even in the presence of standard environmental conditions, which are considered optimal for cell growth. By contrast, several proteins, as those related to heat shock response, or involved in endoplasmic reticulum and membrane trafficking, appeared differentially expressed only during in vitro ageing, suggesting that, at high CPD, the whole cell machinery becomes permanently altered. Finally, given the importance of the elastic component for a long-lasting connective tissue structural and functional compliance, this study focuses also on elastin and fibulin-5 synthesis and deposition, demonstrating a close relationship between fibulin-5 and ageing.
Ključne besede:Ageing Fibroblast Connective tissue Oxidative stress Protein expression Elastin
Leto izida:2010
Št. strani:625-635
Številčenje:131
PID:20.500.12556/RUNG-4695-16d8e3d1-15e9-8095-a6a4-f1747e602515 Novo okno
COBISS.SI-ID:5441019 Novo okno
DOI:10.1016/j.mad.2010.08.008 Novo okno
NUK URN:URN:SI:UNG:REP:GJIOVNFF
Datum objave v RUNG:23.08.2019
Število ogledov:4545
Število prenosov:0
Metapodatki:XML DC-XML DC-RDF
:
BORALDI, Federica, ANNOVI, Giulia, TIOZZO, Roberta, SOMMER, Pascal in QUAGLINO, Daniela, 2010, Comparison of ex vivo and in vitro human fibroblast ageing models. Mechanism of age and development [na spletu]. 2010. Vol. 131, p. 625–635. [Dostopano 11 april 2025]. DOI 10.1016/j.mad.2010.08.008. Pridobljeno s: https://repozitorij.ung.si/IzpisGradiva.php?lang=slv&id=4695
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Gradivo je del revije

Naslov:Mechanism of age and development
Leto izida:2010

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:22.08.2019

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