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Naslov:Heparan Sulfate Affects Elastin Deposition in Fibroblasts Cultured from Donors of Different Ages
Avtorji:ID Annovi, Giulia, Università di Modena e Reggio Emilia (Avtor)
ID Boraldi, Federica, Università di Modena e Reggio Emilia (Avtor)
ID Moscarelli, Pasquale, Università della Basilicata (Avtor)
ID Guerra, Deanna, Università di Modena e Reggio Emilia (Avtor)
ID Tiozzo, Roberta, Università di Modena e Reggio Emilia (Avtor)
ID Parma, Bruna, Opocrin (Avtor)
ID Sommer, Pascal, Institut de Biologie et Chimie des Prote´ines, CNRS– Universite´ Lyon 1 (Avtor)
ID Quaglino, Daniela, Università di Modena e Reggio Emilia (Avtor)
Datoteke: Gradivo nima datotek, ki so prostodostopne za javnost. Gradivo je morda fizično dosegljivo v knjižnici fakultete, zalogo lahko preverite v COBISS-u. Povezava se odpre v novem oknu
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Heparan sulfate (HS), due to its presence on the cell surface and in the extracellular milieu and its ability to modulate cell signaling, has a fundamental role in both physiological and pathological conditions. For decades we have demonstrated the occurrence of interactions between glycosaminoglycans (GAGs) and elastic fibers. In particular, we have recently shown that HS is present inside elastic fibers and plays a role in the assembly and stability of elastin coacervates. Elastin represents, within the extracellular matrix, the component most severely affected during aging, and changes in the synthesis and posttranslational modifications of HS have been described, possibly influencing cellular behavior and protein interactions. Thus, the present study has investigated, in two different in vitro experimental models, the role of HS on elastin deposition and assembly. Results demonstrate that: (1) Biological effects of HS are partly dependent on the physicochemical characteristics of the GAGs; (2) HS does not affect attachment, viability, and growth of human dermal fibroblasts; (3) HS does not modify elastin gene expression nor elastin synthesis, but favors a-elastin aggregation and, independently from the age of donors, elastin assembly; (4) HS significantly increases the expression of fibulin 5, and these effects are especially evident in fibroblasts isolated from aging donors. These data provide a better understanding of the biological role of HS and offer new perspectives regarding the possibility of restoring and/or preserving the elastic component with aging.
Ključne besede:Heparan sulfate, Elastin, Fibroblasts
Leto izida:2012
Št. strani:22-31
Številčenje:15
PID:20.500.12556/RUNG-4697-5731c1ce-7354-e26d-b6fa-16d34a1895da Novo okno
COBISS.SI-ID:5441275 Novo okno
DOI:10.1089/rej.2011.1182 Novo okno
NUK URN:URN:SI:UNG:REP:9HFVVJV2
Datum objave v RUNG:23.08.2019
Število ogledov:4036
Število prenosov:0
Metapodatki:XML DC-XML DC-RDF
:
ANNOVI, Giulia, BORALDI, Federica, MOSCARELLI, Pasquale, GUERRA, Deanna, TIOZZO, Roberta, PARMA, Bruna, SOMMER, Pascal in QUAGLINO, Daniela, 2012, Heparan Sulfate Affects Elastin Deposition in Fibroblasts Cultured from Donors of Different Ages. Rejuvenation research [na spletu]. 2012. Vol. 15, p. 22–31. [Dostopano 12 april 2025]. DOI 10.1089/rej.2011.1182. Pridobljeno s: https://repozitorij.ung.si/IzpisGradiva.php?lang=slv&id=4697
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Gradivo je del revije

Naslov:Rejuvenation research
Leto izida:2012

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:22.08.2019

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