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Title:Circadian rhythm of exhaled biomarkers in health and asthma
Authors:Wilkinson, Max (Author)
Maidstone, Robert (Author)
Loudon, Andrew (Author)
Blaikley, John (Author)
White, Iain (Author)
Singh, Dave (Author)
Ray, David (Author)
Goodacre, Royston (Author)
Fowler, Stephen (Author)
Durrington, Hannah (Author)
Files:This document has no files. This document may have a phisical copy in the library of the organization, check the status via COBISS. Link is opened in a new window
Language:English
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:Circadian rhythms control many biological processes in the body in both health and disease. Greater understanding of diurnal variability in disease related biomarkers is crucial for their application in clinical practice and biomarkers of circadian rhythm are required to facilitate further research into disturbed chronicity. To determine if fractional exhaled nitric oxide and breath volatile biomarkers vary rhythmically during the day in healthy and asthmatic individuals. Ten individuals with moderate, atopic asthma (on regular inhaled corticosteroids) and 10 healthy volunteers (all non-smokers) completed an overnight visit where their exhaled breath volatiles and forced exhaled nitric oxide levels were collected every 6 h. Breath volatiles were analysed using gas chromatography mass spectrometry, after trapping these volatiles on sorbent materials for thermal desorption. Nine breath volatiles (including acetone and isoprene) exhibit diurnal variation across all individuals. Furthermore the circadian pattern of several VOCs is altered in individuals with asthma and fractional exhaled nitric oxide is rhythmic in asthma but not in healthy controls. Markers of circadian rhythm can be identified in breath and may offer insight into circadian profiling to help treat disease. Additionally this work suggests that time of day must be controlled when designing future biomarker discovery studies. Further work is required with larger cohorts to validate and extend these findings.
Keywords:VOCs, breath, asthma, circadian
Year of publishing:2019
Number of pages:4
Numbering:54, 4
COBISS_ID:5466107 Link is opened in a new window
URN:URN:SI:UNG:REP:ZNHSLATV
DOI:10.1183/13993003.01068-2019 Link is opened in a new window
License:CC BY-NC-SA 4.0
This work is available under this license: Creative Commons Attribution Non-Commercial Share Alike 4.0 International
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Record is a part of a journal

Title:European Respiratory Journal
Shortened title:ERJ
Publisher:European Respiratory Society
ISSN:0903-1936
Year of publishing:2019

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