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Title:Effects of alfaxalone or propofol on giant-breed dog neonates viability during elective caesarean sections
Authors:Melandri, Monica (Author)
Peric, Tanja (Author)
et al.
Files:.pdf animals-09-00962.pdf (234,45 KB)
 
Language:English
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:Attention must be paid to C-section anesthesia effects on mother and offspring. Alfaxalone induction results in improved puppy viability when compared to propofol. The present study aims to evaluate effects of alfaxalone or propofol induction for elective C-section on newborns, expressed as Apgar score and fetal fluids cortisol concentration. Anesthesia was induced with alfaxalone 3 mg/kg iv in 5 bitches (group A), and propofol 4 mg/kg iv in another 5 (group P), maintained with isoflurane. Amniotic and allantoic fluids were collected to determine cortisol concentration. Apgar score, litter size, newborn gender, birth-weight, maternal age, and parity were recorded. ANOVA, U Mann-Whitney test and ANCOVA assessed the effects of drugs on the Apgar score and fetal fluids cortisol. Thirty-six puppies were randomly selected for the study: 16 from group A and 20 from group P. Only the Apgar score significantly differed between groups. ANCOVA confirmed a significantly higher Apgar score in group A underlining the influence of fetal fluids cortisol concentrations, both resulting in covariates. Present results confirm the effect of anesthesia on the Apgar score of newborns, which is significantly higher for alfaxalone than propofol, suggesting the use of fetal fluids cortisol as a covariate. These findings could be a starting point for further investigations when less viable puppies are detected or expected, such as during an emergency C-section. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords:Alfaxalone, Apgar score, C-section, Canine neonates, Cortisol, Fetal fluids
Year of publishing:2019
Number of pages:11
Numbering:9, 2019
COBISS_ID:5485563 Link is opened in a new window
URN:URN:SI:UNG:REP:AIYHD2IL
DOI:10.3390/ani9110962 Link is opened in a new window
License:CC BY-NC-ND 4.0
This work is available under this license: Creative Commons Attribution Non-Commercial No Derivatives 4.0 International
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Title:Animals
ISSN:20762615
Year of publishing:2019

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