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Title:Untargeted molecular analysis of exhaled breath as a diagnostic test for ventilator-associated lower respiratory tract infections (BreathDx)
Authors:Oort, Pouline M. van (Author)
Nijsen, Tamara M. E. (Author)
White, Iain R. (Author)
Knobel, Hugo (Author)
Felton, Timothy (Author)
Rattray, Nicholas J. W. (Author)
Lawal, Oluwasola (Author)
Bulut, Murtaza (Author)
Ahmed, Waqar (Author)
Artigas, Antonio (Author)
Files:This document has no files. This document may have a phisical copy in the library of the organization, check the status via COBISS. Link is opened in a new window
Language:English
Work type:Unknown ()
Tipology:1.03 - Short Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.
Keywords:ventilator-associated pneumonia, breath analysis, volatile organic compounds, metabolomics, intensive care, hospital acquired infections
Year of publishing:2021
Number of pages:str. 1-3
Numbering:iss. , Vol.
COBISS_ID:75487235 Link is opened in a new window
UDC:616.2
ISSN on article:0040-6376
URN:URN:SI:UNG:REP:PVOIQNHM
DOI:10.1136/thoraxjnl-2021-217362 Link is opened in a new window
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Title:Thorax
Shortened title:Thorax
Publisher:British Medical Association
ISSN:0040-6376
COBISS.SI-ID:5412615 New window

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