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Naslov:Sustained delivery of Cu(II)-based DNA intercalators by nanometer-sized cyclodextrin-based porous polymers
Avtorji:ID Škorjanc, Tina (Avtor)
ID Heinrich, Julian (Avtor)
ID Makuc, Damjan (Avtor)
ID Kulak, Nora (Avtor)
ID Valant, Matjaž (Avtor)
Datoteke:.pdf skorjanc-et-al-2023-sustained-delivery-of-cu(ii)-based-dna-intercalators-by-nanometer-sized-cyclodextrin-based-porous.pdf (5,10 MB)
MD5: 8C5BB3FF5CBC63730FB06CF8AD1DF317
 
URL https://pubs.acs.org/doi/10.1021/acsanm.3c04219
 
Jezik:Angleški jezik
Vrsta gradiva:Neznano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:DNA intercalators are small molecules that insert between adjacent DNA base pairs and thus disturb DNA replication and transcription, which can lead to cell death. Certain metal complexes are excellent DNA intercalators, and have shown promise in chemotherapy. Here, a cyclodextrin porous polymer was prepared, characterized, exfoliated to form nanometer-sized particles, and used as a delivery vehicle for metal-free and Cu(II)-metalated anthraquinone-based DNA intercalators with a goal to minimize side effects of the highly toxic DNA intercalators. NMR experiments, including DOSY NMR, have shown the interaction between the cyclodextrin building block and the studied DNA intercalators. Porous nature of the delivery vehicle provided ample surface area for interaction with the drug candidates, resulting in encapsulation rates of up to 56%. Sustained cargo release from the polymer was achieved over eight days, and time-dependent cytotoxicity was observed. Furthermore, optical microscopy images indicated delivery vehicle internalization as well as disturbed cellular morphology within 24 hours of incubation. We anticipate that this study will stimulate further interest in the development of polymeric delivery systems for metal complexes.
Ključne besede:porous organic polymers, cyclodextrin, DNA intercalators, Cu(II) complexes, metal complexes
Status publikacije:Objavljeno
Verzija publikacije:Recenzirani rokopis
Datum objave:01.01.2023
Leto izida:2023
Št. strani:str. 21162–21168
Številčenje:Vol. 6, issue 22
PID:20.500.12556/RUNG-8622-4400015f-6a88-4758-2112-fd3c8d03009c Novo okno
COBISS.SI-ID:171624963 Novo okno
UDK:53
ISSN pri članku:2574-0970
DOI:10.1021/acsanm.3c04219 Novo okno
NUK URN:URN:SI:UNG:REP:KHUBGTNG
Datum objave v RUNG:10.11.2023
Število ogledov:2990
Število prenosov:7
Metapodatki:XML DC-XML DC-RDF
:
ŠKORJANC, Tina, HEINRICH, Julian, MAKUC, Damjan, KULAK, Nora in VALANT, Matjaž, 2023, Sustained delivery of Cu(II)-based DNA intercalators by nanometer-sized cyclodextrin-based porous polymers. ACS applied nano materials [na spletu]. 2023. Vol. 6, no. 22. [Dostopano 14 april 2025]. DOI 10.1021/acsanm.3c04219. Pridobljeno s: https://repozitorij.ung.si/IzpisGradiva.php?lang=slv&id=8622
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Gradivo je del revije

Naslov:ACS applied nano materials
Skrajšan naslov:ACS appl. nano mater.
Založnik:American Chemical Society
ISSN:2574-0970
COBISS.SI-ID:32649255 Novo okno

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:P2-0412
Naslov:Heterogeni procesi na površinah trdnin za trajnostne tehnologije

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Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

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