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Naslov:A novel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies
Avtorji:ID De Luca, Roberto (Avtor)
ID Kachel, Paul (Avtor)
ID Kropivšek, Klara (Avtor)
ID Snijder, Berend (Avtor)
ID Manz, Markus G. (Avtor)
ID Neri, Dario (Avtor)
Datoteke:URL http://academic.oup.com/peds/article-pdf/31/5/173/25825666/gzy015.pdf
 
Jezik:Angleški jezik
Vrsta gradiva:Neznano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:A novel dual-cytokine–antibody fusion protein, consisting of an antibody directed against CD38 [a tumor-associated antigen mainly expressed on the surface of multiple myeloma (MM) cells], simultaneously fused to both tumor necrosis factor ligand superfamily member 10 (TRAIL) and interleukin-2 (IL2), was designed, expressed and purified to homogeneity. The novel fusion protein, termed IL2-αCD38-αCD38-scTRAIL, was able to selectively recognize its cognate antigen expressed on the surface of MM and lymphoma cell lines, as evidenced by flow cytometry analysis. Moreover, the targeted version of TRAIL was able to induce cancer cell death in vitro, both with MM cell lines and with fresh isolates from the bone marrow of MM patients. The experiments provide a rationale for possible future applications of IL2-αCD38-αCD38-scTRAIL for the treatment of patients with MM or other CD38-positive malignancies.
Ključne besede:antibodies, dual-cytokine-antibody, CD38, multiple myeloma, TRAIL, IL2
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.01.2018
Leto izida:2018
Št. strani:str. 173-179
Številčenje:Vol. 31, no. 5
PID:20.500.12556/RUNG-9467 Novo okno
ISSN:1741-0126
COBISS.SI-ID:214568195 Novo okno
UDK:57
ISSN pri članku:1741-0126
eISSN:1741-0134
DOI:10.1093/protein/gzy015 Novo okno
NUK URN:URN:SI:UNG:REP:A11OVUW0
Datum objave v RUNG:11.11.2024
Število ogledov:643
Število prenosov:2
Metapodatki:XML DC-XML DC-RDF
:
DE LUCA, Roberto, KACHEL, Paul, KROPIVŠEK, Klara, SNIJDER, Berend, MANZ, Markus G. in NERI, Dario, 2018, A novel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies. Protein engineering, design & selection : PEDS [na spletu]. 2018. Vol. 31, no. 5, p. 173–179. [Dostopano 12 april 2025]. DOI 10.1093/protein/gzy015. Pridobljeno s: http://academic.oup.com/peds/article-pdf/31/5/173/25825666/gzy015.pdf
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Gradivo je del revije

Naslov:Protein engineering, design & selection : PEDS
Založnik:Oxford University Press
ISSN:1741-0126
COBISS.SI-ID:19649831 Novo okno

Licence

Licenca:Drugo
Opis:https://academic.oup.com/journals/pages/about_us/legal/notices
Začetek licenciranja:05.07.2018

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