20.500.12556/RUNG-6203
Treatment strategies targeting persister cell formation in bacterial pathogens
Persister cells are transiently antibiotic-tolerant and dormant subpopulations that are produced to escape the effects of antibiotics within biofilms or planktonic cell populations. Persister cells are of high clinical importance due to their tolerance to antimicrobial agents and subsequent failure in antibiotic treatments. Understanding persister cell formation mechanisms is therefore highly important for developing effective therapeutic strategies against pathogenic bacterial persisters. Several anti-persister compounds have been previously identified via isolation from natural resources or chemical synthesis. Furthermore, a combination of these compounds with antibiotics or non-antibiotic drugs also allows action on multiple targets while reducing the administration frequency. Here, we present a comprehensive overview of the clinical importance and formation mechanisms of persister cells as well as the current treatment strategies against persister cell formations in chronic infections.
Biofilm
anti-persister agents
persister cells
pathogenic bacteria
chronic infections
true
true
false
Angleški jezik
Ni določen
Delo ni kategorizirano
2021-01-14 12:08:04
2021-01-14 15:44:39
2023-06-09 03:42:10
0000-00-00 00:00:00
2020
0
0
665-688
46
6
2020
0000-00-00
NiDoloceno
NiDoloceno
NiDoloceno
0000-00-00
0000-00-00
0000-00-00
47104259
10.1080/1040841X.2020.1822278
URN:SI:UNG:REP:P60IPYY7
Univerza v Novi Gorici
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1
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