11. Univerza v Novi Gorici, Spremljanje, ugotavljanje in zagotavljanje kakovosti, Poročilo za študijsko leto 2015/2016Martina Bergant Marušič, Lorena Butinar, IMRE CIKAJLO, Saša Dobričič, Renata Kop, Urška Lavrenčič Štangar, Martin Knez, Boštjan Potokar, Branka Mozetič Vodopivec, Egon Pavlica, Samo Stanič, Tea Stibilj Nemec, Arthur Stepanov, Veronika Piccinini, Tamara Podveršič, Peter Purg, Aljaž Rener, Nives Štefančič, Ana Toroš, Tanja Urbančič, Vanesa Valentinčič, Aleš Vaupotič, Sabina Zelinšček, 2016, elaborat, predštudija, študija Ključne besede: zagotavljanje kakovosti, visoko šolstvo, univerza Objavljeno v RUNG: 05.02.2018; Ogledov: 4335; Prenosov: 0 Gradivo ima več datotek! Več... |
12. Univerza v Novi Gorici, Spremljanje, ugotavljanje in zagotavljanje kakovosti, Poročilo za študijsko leto 2014/2015Martina Bergant Marušič, Aleš Bogovič, Lorena Butinar, IMRE CIKAJLO, Saša Dobričič, Elsa Fabbretti, Renata Kop, Urška Lavrenčič Štangar, Martin Knez, Katja Mihurko, Branka Mozetič Vodopivec, Egon Pavlica, Samo Stanič, Tea Stibilj Nemec, Arthur Stepanov, Boštjan Potokar, Veronika Piccinini, Peter Purg, Aljaž Rener, Nives Štefančič, Ana Toroš, Tanja Urbančič, Vanesa Valentinčič, Aleš Vaupotič, Sabina Zelinšček, 2015, elaborat, predštudija, študija Ključne besede: zagotavljanje kakovosti, visoko šolstvo, univerza Objavljeno v RUNG: 05.02.2018; Ogledov: 4546; Prenosov: 0 Gradivo ima več datotek! Več... |
13. Univerza v Novi Gorici, Spremljanje, ugotavljanje in zagotavljanje kakovosti, Poročilo za študijsko leto 2013/2014Iztok Arčon, Martina Bergant Marušič, Aleš Bogovič, Lorena Butinar, Gvido Bratina, IMRE CIKAJLO, Saša Dobričić, Elsa Fabbretti, Mladen Franko, Renata Kop, Urška Lavrenčič Štangar, Martin Knez, Katja Mihurko, Jana Laganis, Branka Mozetič Vodopivec, Egon Pavlica, Ingrid Petrič, Samo Stanič, Tea Stibilj Nemec, Arthur Stepanov, Boštjan Potokar, Veronika Piccinini, Peter Purg, Aljaž Rener, Nives Štefančič, Ana Toroš, Tanja Urbančič, Vanesa Valentinčič, Aleš Vaupotič, Sabina Zelinšček, 2014, elaborat, predštudija, študija Ključne besede: zagotavljanje kakovosti, visoko šolstvo, univerza Objavljeno v RUNG: 05.02.2018; Ogledov: 4407; Prenosov: 0 Gradivo ima več datotek! Več... |
14. Univerza v Novi Gorici, Fakulteta za znanosti o okolju: Spremljanje, ugotavljanje in zagotavljanje kakovosti Poročilo za študijsko leto 2013/2014 z analizo vseh področij delovanja iz vseh let po zadnji akreditacijiIztok Arčon, Marina Artico, Janja Humar, Renata Kop, Veronika Piccinini, Urška Lavrenčič Štangar, Tea Stibilj Nemec, Lucija Vidrih, Sabina Zelinšček, 2014, elaborat, predštudija, študija Ključne besede: zagotavljanje kakovosti, visoko šolstvo, akreditacija, univerza Objavljeno v RUNG: 05.02.2018; Ogledov: 4120; Prenosov: 0 Gradivo ima več datotek! Več... |
15. Bilirubin is an Endogenous Antioxidant in Human Vascular Endothelial CellsLovro Žiberna, Mitja Martelanc, Mladen Franko, Sabina Passamonti, 2016, izvirni znanstveni članek Opis: Bilirubin is a standard serum biomarker of liver function. Inexplicably, it is inversely correlated with
cardiovascular disease risk. Given the role of endothelial dysfunction in originating cardiovascular
diseases, direct analysis of bilirubin in the vascular endothelium would shed light on these relationships.
Hence, we used high-performance liquid chromatography coupled with thermal lens spectrometric
detection and diode array detection for the determination of endogenous cellular IXα-bilirubin. To
confirm the isomer IXα-bilirubin, we used ultra-performance liquid chromatography coupled with a
high-resolution mass spectrometer using an electrospray ionization source, as well as tandem mass
spectrometric detection. We measured bilirubin in both arterial and venous rat endothelium (0.9–1.5
pmol mg−1 protein). In the human endothelial Ea.hy926 cell line, we demonstrated that intracellular
bilirubin (3–5 pmol mg−1 protein) could be modulated by either extracellular bilirubin uptake, or by
up-regulation of heme oxygenase-1, a cellular enzyme related to endogenous bilirubin synthesis.
Moreover, we determined intracellular antioxidant activity by bilirubin, with EC50 = 11.4 ± 0.2 nM, in
the range of reported values of free serum bilirubin (8.5–13.1 nM). Biliverdin showed similar antioxidant
properties as bilirubin. We infer from these observations that intra-endothelial bilirubin oscillates, and
may thus be a dynamic factor of the endothelial function. Ključne besede: Antioxidants, bilirubin, endothelial cells Objavljeno v RUNG: 07.07.2016; Ogledov: 5196; Prenosov: 406 Celotno besedilo (585,86 KB) Gradivo ima več datotek! Več... |
16. Application of high-performance liquid chromatography combined with ultra-sensitive thermal lens spectrometric detection for simultaneous biliverdin and bilirubin assessment at trace levels in human serumMitja Martelanc, Lovro Žiberna, Sabina Passamonti, Mladen Franko, 2016, izvirni znanstveni članek Opis: We present the applicability of a new ultra sensitive analytical method for the simultaneous determination of biliverdin and bilirubin in human serum. The method comprises isocratic reversed-phase(RP) C18 high-performance liquid chromatography (HPLC) and thermal lens spectrometric detection (TLS)based on excitation by a krypton laser emission line at 407 nm. This method enables the separation of IX-α biliverdin and IX-α bilirubin in 11 min. with limit of detection (LOD) and limit of quantitation (LOQ) for
biliverdin of 1.2 nM and 3 nM, and 1nM and 2.8 nM for bilirubin,respectively.In addition, a step-gradient elution was set up, by changing the mobile phase composition, in order to further enhance the sensitivity for bilirubin determination with LOD and LOQ of 0.5 nM and 1.5 nM, respectively. In parallel, an isocraticHPLC-DAD method was developed for benchmarking against HPLC-TLS methods. The LOD
and LOQ forbiliverdin were 6 nM and 18 nM, and 2.5 nM and 8nM for bilirubin,respectively. Additionally, both isocratic methods were applied for measuring biliverdin and free bilirubin in human serum samples (from 2 male and 2 female healthy donors). Combining isocratic HPLC method with TLS
detector was crucial for first ever biliverdin determination in serum together with simultaneous free bilirubin determination. We showed for the first time the concentration ratio of free bilirubin versus unbound biliverdin in human serum samples. Ključne besede: Bilirubin, biliverdin, serum, HPLC, TLS Objavljeno v RUNG: 29.03.2016; Ogledov: 5777; Prenosov: 0 Gradivo ima več datotek! Več... |
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