1. Characterization of sustainable biocompatible materials based on chitosan : cellulose composites containing sporopollenin exine capsulesDorota Korte, Mohanachandran Nair Sindhu Swapna, Hanna Budasheva, Patricia Cazón, Manisha Chhikara, Tina Škorjanc, Carmen Tripon, Alexandra Farcas, Egon Pavlica, Chieu D. Tran, Mladen Franko, 2024, izvirni znanstveni članek Ključne besede: material characterization, biocompatible materials, chitosan, sporopollenin exine capsules, beam deflection spectrometry
Objavljeno v RUNG: 29.10.2024; Ogledov: 73; Prenosov: 0
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2. Analysis of drug release from CS : CEL based biocomposites modified with antibiotic-loaded sporopolleninDorota Korte, Matevž Može Davidović, Mohanachandran Nair Sindhu Swapna, Petra Makorič, Chieu D. Tran, Mladen Franko, 2024, objavljeni povzetek znanstvenega prispevka na konferenci Ključne besede: CS:CEL based biocomposites, porosity, thermal properties, beam deflection spectrometry
Objavljeno v RUNG: 23.09.2024; Ogledov: 353; Prenosov: 1
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5. Porosity engineering in cellulose-chitosan composites via sporopollenin incorporation for wound healing applicationsMohanachandran Nair Sindhu Swapna, Petra Makorič, Dorota Korte, Chieu D. Tran, Mladen Franko, 2023, objavljeni povzetek znanstvenega prispevka na konferenci Ključne besede: cellulose, chitosan, composite, wound healing, photothermal beam deflection, porosity
Objavljeno v RUNG: 16.10.2023; Ogledov: 1512; Prenosov: 0
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6. Natural sporopollenin microcapsules composites from cellulose and chitosan : synthesis and characterizationPatricia Cazón, Hanna Budasheva, Dorota Korte, Mark Mitmoen, Chieu D. Tran, Mladen Franko, 2021, objavljeni povzetek znanstvenega prispevka na konferenci Ključne besede: CS:CL biocomposites, beam deflection spectrometry, natural sporopollenin, porosity
Objavljeno v RUNG: 31.01.2022; Ogledov: 2704; Prenosov: 17
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8. Facile synthesis, structure, biocompatibility and antimicrobial property of gold nanoparticle composites from cellulose and keratinChieu D. Tran, Franja Prosenc, Mladen Franko, 2018, izvirni znanstveni članek Opis: A novel, one-pot method was developed to synthesize gold nanoparticle composite from cellulose (CEL), wool keratin (KER) and chloroauric acid. Two ionic liquids, butylmethylimmidazolium chloride and ethylmethylimmidazolium bis(trifluoromethylsulfonyl)imide were used to dissolve CEL, KER and HAuCl4. X-ray diffraction and X-ray photoelectron results show that Au3+ was completely reduced to Au0NPs with size of (5.5 ± 1) nm directly in the composite with NaBH4. Spectroscopy and imaging results indicate that CEL and KER remained chemically intact and were homogeneously distributed in the com- posites with Au0NPs. Encapsulating Au0NPs into [CEL+KER] composite made the composite fully biocom- patible and their bactericidal capabilities were increased by the antibacterial activity of Au0NPs. Specifically, the [CEL+KER+Au0NPs] composite exhibited up to 97% and 98% reduction in growth of antibi- otic resistant bacteria such as vancomycin resistant Enterococcus faecalis and methicillin resistant Staphylococcus aureus, and was not cytotoxic to human fibroblasts. While [CEL+KER] composite is known to possess some antibacterial activity, the enhanced antibacterial observed here was due solely to added Au0NPs. These results together with our previous finding that [CEL+KER] composites can be used for con- trolled delivery of drugs clearly indicate that the [CEL+KER+Au0NPs] composites possess all required properties for successful use as dressing to treat chronic ulcerous infected wounds.
Ključne besede: Ionic liquid
Green
Sustainable
Polysaccharide
Keratin
Wound dressing
Gold nanoparticles Antibiotic-resistant bacteria
Objavljeno v RUNG: 27.09.2017; Ogledov: 5136; Prenosov: 0
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9. One-pot synthesis of biocompatible silver nanoparticle composites from cellulose and keratin: characterization and antimicrobial activityChieu Ding Tran, Franja Prosenc, Mladen Franko, Gerald Benzi, 2016, izvirni znanstveni članek Opis: A novel, simple method was developed to synthesize biocompatible composites containing 50% cellulose (CEL) and 50% keratin (KER) and silver in the form of either ionic (Ag+) or Ag0 nanoparticle (Ag+NPs or Ag0NPs). In this method, butylmethylimmidazolium chloride ([BMIm+Cl-]), a simple ionic liquid, was used as the sole solvent and silver chloride was added to the [BMIm+Cl-] solution of [CEL+KER] during the dissolution process. The silver in the composites can be maintained as ionic silver (Ag+) or completely converted to metallic silver (Ag0) by reducing it with NaBH4. Results of spectroscopy (Fourier-transform infrared (FTIR), X-ray diffraction (XRD)) and imaging (scanning electron microscope (SEM)) measurements confirm that CEL and KER remain chemically intact and homogeneously distributed in the composites. Powder X-ray diffraction (XRD) and SEM results show that the silver in the [CEL+KER+Ag+] and [CEL+KER+Ag0] composites is homogeneously distributed throughout the composites in either Ag+ (in the form of Ag2O nanoparticles (NPs)) or Ag0NPs form with size of (9 ± 1) nm or (27 ± 2) nm, respectively. Both composites were found to exhibit excellent antibacterial activity against many bacteria including Escherichia coli, Staphylococus aureus, Pseudomonas aeruginosa, methicillin resistant Staphylococus aureus (MRSA), vancomycin resistant Enterococus faecalis (VRE). The antibacterial activity of both composites increases with the Ag+ or Ag0 content in the composites. More importantly, for the same bacteria and the same silver content, [CEL+KER+Ag0] composite exhibits relatively greater antimicrobial activity against bacteria compared to the corresponding [CEL+KER+Ag+] composite. Experimental results confirm that there was hardly any Ag0NPs release from the [CEL+KER+Ag0NPs] composite, and hence its antimicrobial activity and biocompatibility is due, not to any released Ag0NPs but rather entirely to the Ag0NPs embedded in the composite. Both Ag2ONPs or Ag0NPs were found to be toxic to human fibroblasts at higher concentration (>0.72 mmol), and that for the same silver content, [CEL+KER+Ag2ONPs] composite is relatively more toxic than [CEL+KER+Ag0NPs] composite. As expected, by lowering the Ag0NPs concentration to 0.48 mmol or less, the [CEL+KER+Ag0NPs] composite can be made biocompatible while still retaining its antimicrobial activity against bacteria such are E. coli, S. aureus, P. aeruginosa, MRSA, VRE. These results together with our previous finding that [CEL+KER] composites can be used for controlled delivery of drugs such as ciprofloxacin clearly indicate that the [CEL+KER+Ag0NPs] composite possess all required properties for successfully used as high performance dressing to treat chronic ulcerous infected wounds.
Ključne besede: Celulose, Keratin, Cmposites, Biocompatible, Ag nanoparticles, one-pot synthesis, Antibacterial, Antiviral
Objavljeno v RUNG: 28.11.2016; Ogledov: 5847; Prenosov: 0
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10. Synthesis, Structure and Antimicrobial Property of Green Composites from Cellulose, Wool, Hair and Chicken FeatherChieu Tran, Franja Prosenc, Mladen Franko, Gerald Benzi, 2016, izvirni znanstveni članek Opis: Novel composites between cellulose (CEL) and keratin (KER) from three different sources (wool, hair and chicken feather) were successfully synthesized in a simple one-step
process in which butylmethylimidazolium chloride (BMIm+Cl-), an ionic liquid, was used as the sole solvent. The method is green and recyclable because [BMIm+Cl-] used was recovered for reuse. Spectroscopy (FTIR, XRD) and imaging (SEM) results confirm that CEL and KER remain chemically intact and homogeneously distributed in the composites. KER retains some of its secondary structure in the composites. Interestingly, the minor differences in the structure of
KER in wool, hair and feather produced pronounced differences in the conformation of their corresponding composites with wool has the highest α-helix content and feather has the lowest content. These results correlate well with mechanical and antimicrobial properties of the composites. Specifically, adding CEL into KER substantially improves mechanical strength of [CEL+KER] composites made from all three different sources, wool, hair and chicken feathers (i.e., [CEL+wool], [CEL+hair] and [CEL+feather]. Since mechanical strength is due to CEL, and CEL has only random structure, [CEL+feather] has, expectedly, the strongest mechanical property because feather has the lowest content of α-helix. Conversely, [CEL+wool] composite
has the weakest mechanical strength because wool has the highest α-helix content. All three composites exhibit antibacterial activity against methicillin resistant S. aureus (MRSA). The antibacterial property is due not to CEL but to the protein and strongly depends on the type of the
keratin, namely, the bactericidal effect is strongest for feather and weakest for wool. These results together with our previous finding that [CEL+KER] composites can control release of drug such as ciprofloxacin clearly indicate that these composites can potentially be used as wound dressing.
Ključne besede: Green synthesis, Ionic liquid, Keratin, Antibacteria, Wound dressing
Objavljeno v RUNG: 08.06.2016; Ogledov: 5179; Prenosov: 0
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