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1.
Novel bispecific nanobody mitigates experimental intestinal inflammation in mice by targeting TNF-▫$\alpha$▫ and IL-23p19 bioactivities
Jiewen Wang, Guangbo Kang, Huiying Lu, Ario De Marco, Haibin Yuan, Zelin Feng, Mengxue Gao, Xiaoli Wang, Huahong Wang, Xiaolan Zhang, 2024, original scientific article

Keywords: bispecific constructs, nanobodies, intestinal inflammation
Published in RUNG: 27.03.2024; Views: 2390; Downloads: 10
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2.
Affinity maturation of antibody fragments : a review encompassing the development from random approaches to computational rational optimization
Jiaqi Liu, Guangbo Kang, Jiewen Wang, Haibin Yuan, Yili Wu, Shuxian Meng, Ping Wang, Miao Zhang, Yuli Wang, Yuanhang Feng, He Huang, Ario De Marco, 2023, review article

Keywords: deep learning, protein modeling, random mutagenesis, rational mutagenesis
Published in RUNG: 17.07.2023; Views: 2612; Downloads: 9
.pdf Full text (2,21 MB)

3.
Design of nanobody-based bispecific constructs by in silico affinity maturation and umbrella sampling simulations
Zixuan Bai, Jiewen Wang, Jiaqi Liu, Haibin Yuan, Ping Wang, Miao Zhang, Yuanhang Feng, Xiangtong Cao, Xiangan Cao, Guangbo Kang, Ario De Marco, He Huang, 2023, original scientific article

Keywords: nanobody rational design, bispecific binders, protein activity inhibition
Published in RUNG: 03.01.2023; Views: 2834; Downloads: 7
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4.
Research progress and applications of multivalent, multispecific and modified nanobodies for disease treatment
Jiewen Wang, Guangbo Kang, Haibin Yuan, Xiaocang Cao, He Huang, Ario De Marco, 2022, original scientific article

Keywords: nanobody multimers, immunomodulation, intrabodies, imaging, nanobody functionalization
Published in RUNG: 18.01.2022; Views: 3082; Downloads: 162
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