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Contribution of APOBEC proteins 3A and 3B to the oncogenicity of HPV viruses
Nika Marija Lovšin, Fabio Lapenta, Urša Pečar Fonović, Katerina Jazbec, Elvira Maličev, Martina Bergant Marušič, 2023, published scientific conference contribution abstract

Keywords: APOBEC, HPV, oncogenicity, gene expression
Published in RUNG: 10.10.2023; Views: 259; Downloads: 9
.pdf Full text (7,73 MB)

In vitro tumor hypoxia imaging with fluorescent covalent organic frameworks
Tina Skorjanc, Dinesh Shetty, Damjan Makuc, Gregor Mali, Martina Bergant Marušič, Matjaz Valant, 2023, published scientific conference contribution abstract

Abstract: Hypoxia refers to a condition where cells and tissues experience low, inadequate levels of O2. While healthy tissues are typically supplied with sufficient O2 (normoxia), cancerous tissues commonly face hypoxia due to the tumor’s extraordinarily high demand for oxygen. Various fluorescent small-molecule probes have been designed for selective detection of hypoxia in living cells, but few nanomaterials have been investigated for this type of bioimaging. Herein, we prepare a fluorescent covalent organic framework (COF) with β-ketoenamine linkages and post-synthetically modify it to conjugate hypoxia-sensitive nitroimidazole moieties into its pores (NI-COF). Stacks of sheets in NI-COF observed under electron microscopy were exfoliated by ultrasonication, and dynamic light scattering measurements confirmed particle size of less than 200 nm. Thus-prepared material exhibited good stability in physiological conditions and low cytotoxicity in in vitro experiments. NI-COF also showed useful fluorescence properties with an emission peak at 490 nm (λex = 420 nm) at both neutral and mildly acidic pH levels that are characteristic of tumor tissues. Encouraged by the favorable properties of the material, we incubated HeLa cells pre-treated in either hypoxic or normoxic conditions with NI-COF. Fluorescence microscopy images demonstrated that the material was preferentially taken up by hypoxic cells, which showed higher fluorescence signal in their interior than cells cultured under normoxia conditions. It is anticipated that this study will stimulate further developments of COFs for imaging various biological conditions.
Keywords: hypoxia, fluorescence, covalent organic frameworks, imaging, tumor cells
Published in RUNG: 19.09.2023; Views: 348; Downloads: 3
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APOBEC proteins play an important role in Human papillomavirus infection and oncogenesis
Martina Bergant Marušič, Fabio Lapenta, Nika Marija Lovšin, 2023, published scientific conference contribution abstract (invited lecture)

Keywords: HPV, APOBEC, oncogenesis, infection
Published in RUNG: 20.07.2023; Views: 471; Downloads: 5
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Correlation of APOBEC3A and APOBEC3B gene expression in HNSCC TCGA study
Fabio Lapenta, Christina Paparokidou, Martina Bergant Marušič, 2022, published scientific conference contribution abstract

Keywords: HPV, APOBEC proteins, gene expression, TCGA data
Published in RUNG: 29.11.2022; Views: 774; Downloads: 38
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Diagnostics and Monitoring of COVID-19 Infection – Current Understanding
Martina Bergant, Ario de Marco, 2020, review, book review, critique

Keywords: SARS-CoV-2, RT-PCR, seroconversion, serum biomarkers, neutralizing antibodies
Published in RUNG: 30.09.2022; Views: 824; Downloads: 18
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Frontiers in cellular and infection microbiology

Published in RUNG: 14.09.2022; Views: 896; Downloads: 7
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Human papillomaviruses interfere with host cell processes during infection
Martina Bergant Marušič, invited lecture at foreign university

Keywords: human papillomaviruses, APOBEC, infection, oncogenesis
Published in RUNG: 07.07.2022; Views: 928; Downloads: 0
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