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91.
Nanobodies: towards rational design of immune-reagents
Ario De Marco, 2017, objavljeni povzetek znanstvenega prispevka na konferenci (vabljeno predavanje)

Opis: Antibodies are irreplaceable reagents in both research and clinical practice. Despite their relevance, the structural complexity of conventional mono- and polyclonal antibodies (IgG) has always been a limit for their engineering towards reagents optimized for specific applications, such as in vivo diagnostics and therapy. Furthermore, their isolation is time consuming, their production expensive, and their functionalization results often in heterogeneous macromolecule populations. These drawbacks promoted the search for both innovative antibody isolation strategies and alternative scaffolds. In vitro panning of pre-immune collections of recombinant antibody fragments allows for the simple and fast recovery of binders. Since they did not undergo somatic maturation, their affinity for targets can be insufficient but on the other hand they can be rapidly mutated by standard molecular biology techniques to generate second-generation antibodies among which to identify clones with improved characteristics. Both stochastic and rational methods have been proposed for the optimization process. Random mutagenesis followed by panning at stringent conditions has been successful used to select binders with improved physical characteristics. Rational methods try to identify in silico key residues involved in the regulation of specific antibody features, such as stability or binding affinity. The accuracy of these methods usually depends on the calculation resources. In this perspective, smaller molecules can be analyzed “better” than larger because of their restricted number of residues. Nanobodies small dimensions have been long appreciated since enable better tissue penetration, shorter clearance time, higher yields. Now it becomes evident that this characteristic makes them also optimal objects for modeling.
Ključne besede: recombinant antibody modeling, nanobody engineering, molecular dynamics and docking
Objavljeno v RUNG: 21.03.2018; Ogledov: 4375; Prenosov: 0
Gradivo ima več datotek! Več...

92.
Nanobodies: flexible structures for biotechnological applications
Ario De Marco, vabljeno predavanje na konferenci brez natisa

Ključne besede: nanobodies, in vitro panning, extracellular vesicles, oncology, toxic algae
Objavljeno v RUNG: 16.03.2018; Ogledov: 3619; Prenosov: 0
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93.
Nanomaterial bio-activation and macromolecules functionalization: the search for reliable protocols
Ario De Marco, 2018, pregledni znanstveni članek

Ključne besede: protein functionalization, tags, site-directed protein labeling, sample homogeneity
Objavljeno v RUNG: 28.02.2018; Ogledov: 3654; Prenosov: 0
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94.
A caccia di proteine usando gli anticorpi come esca
Ario De Marco, vabljeno predavanje na konferenci brez natisa

Ključne besede: Fluorescent proteins, antibodies, microscopy, diagnostics
Objavljeno v RUNG: 13.02.2018; Ogledov: 3607; Prenosov: 0
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Naked protein nanoparticles
Ario De Marco, 2017, objavljeni povzetek znanstvenega prispevka na konferenci (vabljeno predavanje)

Ključne besede: Protein nanoparticles, targeted delivery, cell uptake
Objavljeno v RUNG: 15.12.2017; Ogledov: 3351; Prenosov: 415
.pdf Celotno besedilo (2,09 MB)

98.
In vitro isolation of anti Alexandrium minutum nanobodies from a pre-immune library
Elisa Mazzega, Alfred Beran, Marina Cabrini, Ario De Marco, 2017, objavljeni povzetek znanstvenega prispevka na konferenci

Ključne besede: nanobodies, toxic microalgae, biopanning
Objavljeno v RUNG: 04.12.2017; Ogledov: 4106; Prenosov: 33
URL Povezava na celotno besedilo
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Engineered cross-reacting nanobodies simplify comparative oncology between humans and dogs
Elisa Mazzega, Ario De Marco, 2017, izvirni znanstveni članek

Ključne besede: HER2, nanobodies, inter-species cross-reactivity, thermophoresis
Objavljeno v RUNG: 19.10.2017; Ogledov: 4507; Prenosov: 0
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