1. The relationship between exhaled volatile organic compounds and lung function change in idiopathic pulmonary fibrosisConal Hayton, Waqar Ahmed, Dayle Terrington, Iain R. White, Nazia Chaudhuri, Colm Leonard, Andrew M. Wilson, Stephen J. Fowler, 2025, izvirni znanstveni članek Opis: Volatile organic compounds (VOCs) in exhaled breath have shown promise as biomarkers in idiopathic pulmonary fibrosis (IPF). We analysed breath from 57 people with IPF using thermal desorption–gas chromatography–mass spectrometry to identify VOCs related to lung function change over 12 months. A LASSO regression model selected 63 VOCs associated with relative change in forced vital capacity (8 with correlation coefficient (CC) ≥0.20 on Spearman’s rank analysis), and 28 associated with relative change in diffusion capacity of the lung for carbon monoxide % predicted (12 with CC ≥0.20). Secondary analyses demonstrated a correlation between VOCs and baseline lung function parameters and association with survival. This study suggests that there may be a volatile signature of prognosis in IPF that merits further validation.
Ključne besede: idiopathic pulmonary fibrosis, volatile organic compound, thermal desorption mass spectrometry, exhaled breath
Objavljeno v RUNG: 13.05.2025; Ogledov: 136; Prenosov: 1
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2. Fermi-GBM discovery of GRB 221009A : an extraordinarily bright GRB from onset to afterglowS. Lesage, P. Veres, M. S. Briggs, A. Goldstein, D. Kocevski, E. Burns, C. A. Wilson-Hodge, P. N. Bhat, D. Huppenkothen, Gabrijela Zaharijas, 2023, izvirni znanstveni članek Ključne besede: gamma-ray bursts, GRB 221009A, cosmic ray astronomy
Objavljeno v RUNG: 15.01.2024; Ogledov: 1837; Prenosov: 5
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3. Changes in exhaled volatile organic compounds following indirect bronchial challenge in suspected asthmaAdam Peel, Ran Wang, Waqar Ahmed, Iain R. White, Maxim Wilkinson, Yoon K. Loke, Andrew M. Wilson, Stephen J. Fowler, 2023, izvirni znanstveni članek Opis: Background Inhaled mannitol provokes bronchoconstriction via mediators released during osmotic degranulation of inflammatory cells, and, hence represents a useful diagnostic test for asthma and model for acute attacks. We hypothesised that the mannitol challenge would trigger changes in exhaled volatile organic compounds (VOCs), generating both candidate biomarkers and novel insights into their origin.
Methods Participants with a clinical diagnosis of asthma, or undergoing investigation for suspected asthma, were recruited. Inhaled mannitol challenges were performed, followed by a sham challenge after 2 weeks in participants with bronchial hyper-responsiveness (BHR). VOCs were collected before and after challenges and analysed using gas chromatography–mass spectrometry.
Results Forty-six patients (mean (SD) age 52 (16) years) completed a mannitol challenge, of which 16 (35%) were positive, and 15 of these completed a sham challenge. Quantities of 16 of 51 identified VOCs changed following mannitol challenge (p<0.05), of which 11 contributed to a multivariate sparse partial least square discriminative analysis model, with a classification error rate of 13.8%. Five of these 16 VOCs also changed (p<0.05) in quantity following the sham challenge, along with four further VOCs. In patients with BHR to mannitol distinct postchallenge VOC signatures were observed compared with post-sham challenge.
Conclusion Inhalation of mannitol was associated with changes in breath VOCs, and in people with BHR resulted in a distinct exhaled breath profile when compared with a sham challenge. These differentially expressed VOCs are likely associated with acute airway inflammation and/or bronchoconstriction and merit further investigation as potential biomarkers in asthma.
Ključne besede: asthma, exhaled volatile organic compounds, pulmonology, breath metabolomics
Objavljeno v RUNG: 31.07.2023; Ogledov: 2764; Prenosov: 5
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