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Opis: With data on the depth of maximum Xmax collected during more than a decade of operation of the Pierre Auger Observatory, we report on the inferences on the mass composition of UHECRs in the energy range E = 10[sup]17.2 − 10[sup]19.6 eV and on the measurements of the proton-air cross section for energies up to 10[sup]18.5 eV. We also present the results on Xmax obtained using the information on the particle arrival times recorded by the SD stations allowing us to extend the Xmax measurements up to 10[sup]20 eV. The inferences on mass composition, in particular using the data of the SD, are subject to systematic uncertainties due to uncertainties in the description of hadronic interactions at ultra-high energies. We discuss this problem with respect to the properties of the muonic component of extensive air-showers as derived from the SD data.
Ključne besede: ultra-high-energy cosmic rays (UHECRs), extensive air showers (EAS), EAS muonic component, EAS electromagnetic component, Pierre Auger Observatory, UHECR mass composition, UHECR hadronic interactions
Objavljeno v RUNG: 11.10.2023; Ogledov: 659; Prenosov: 8
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Opis: The Pierre Auger Observatory has been very successful in determining many aspects of the highest-energy cosmic rays including, among others, the flux suppression at energies above 4 × 10[sup]19 eV, stringent upper limits on photon and neutrino fluxes at ultra-high energies and an unexpected evolution of the mass composition with energy. We expect an extension of the frontiers of our knowledge on these aspects from a major upgrade of the Observatory. The upgrade, known as AugerPrime, will include an addition of a 4 sq. m Surface Scintillator Detector atop each water-Cherenkov station of the Surface array. The new detectors will provide us with an unprecedented opportunity to perform a complementary measurement of the shower particles and thus determine the primary mass composition with good accuracy on an event-by-event basis. AugerPrime will also include an upgrade of electronics, installation of the AMIGA Underground Muon Detector and a change of observation mode of the Fluorescence Detector, which will increase its current duty cycle by about 50%. Current status of the upgrade with the main focus on the Surface Scintillator Detectors will be presented, following a brief description of the physics motivation for the upgrade.
Ključne besede: ultra-high-energy cosmic rays (UHECRs), Pierre Auger Observatory, AugerPrime upgrade
Objavljeno v RUNG: 11.10.2023; Ogledov: 910; Prenosov: 5
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Opis: Background Inhaled mannitol provokes bronchoconstriction via mediators released during osmotic degranulation of inflammatory cells, and, hence represents a useful diagnostic test for asthma and model for acute attacks. We hypothesised that the mannitol challenge would trigger changes in exhaled volatile organic compounds (VOCs), generating both candidate biomarkers and novel insights into their origin. Methods Participants with a clinical diagnosis of asthma, or undergoing investigation for suspected asthma, were recruited. Inhaled mannitol challenges were performed, followed by a sham challenge after 2 weeks in participants with bronchial hyper-responsiveness (BHR). VOCs were collected before and after challenges and analysed using gas chromatography–mass spectrometry. Results Forty-six patients (mean (SD) age 52 (16) years) completed a mannitol challenge, of which 16 (35%) were positive, and 15 of these completed a sham challenge. Quantities of 16 of 51 identified VOCs changed following mannitol challenge (p<0.05), of which 11 contributed to a multivariate sparse partial least square discriminative analysis model, with a classification error rate of 13.8%. Five of these 16 VOCs also changed (p<0.05) in quantity following the sham challenge, along with four further VOCs. In patients with BHR to mannitol distinct postchallenge VOC signatures were observed compared with post-sham challenge. Conclusion Inhalation of mannitol was associated with changes in breath VOCs, and in people with BHR resulted in a distinct exhaled breath profile when compared with a sham challenge. These differentially expressed VOCs are likely associated with acute airway inflammation and/or bronchoconstriction and merit further investigation as potential biomarkers in asthma.
Ključne besede: asthma, exhaled volatile organic compounds, pulmonology, breath metabolomics
Objavljeno v RUNG: 31.07.2023; Ogledov: 865; Prenosov: 3
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Ključne besede: AFM, chitosan, graphene oxide, fuel cells, membrane, roughness
Objavljeno v RUNG: 01.03.2023; Ogledov: 1307; Prenosov: 3
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Opis: Background: Ventilator-associated pneumonia (VAP) is associated with high morbidity and health care costs, yet diagnosis remains a challenge. Analysis of airway microbiota by amplicon sequencing provides a possible solution, as pneumonia is characterised by a disruption of the microbiome. However, studies evaluating the diagnostic capabilities of microbiome analysis are limited, with a lack of alignment on possible biomarkers. Using bronchoalveolar lavage fluid (BALF) from ventilated adult patients suspected of VAP, we aimed to explore how key characteristics of the microbiome differ between patients with positive and negative BALF cultures and whether any differences could have a clinically relevant role. Methods: BALF from patients suspected of VAP was analysed using 16s rRNA sequencing in order to: (1) differentiate between patients with and without a positive culture; (2) determine if there was any association between microbiome diversity and local inflammatory response; and (3) correctly identify pathogens detected by conventional culture. Results: Thirty-seven of 90 ICU patients with suspected VAP had positive cultures. Patients with a positive culture had significant microbiome dysbiosis with reduced alpha diversity. However, gross compositional variance was not strongly associated with culture positivity (AUROCC range 0.66–0.71). Patients with a positive culture had a significantly higher relative abundance of pathogenic bacteria compared to those without [0.45 (IQR 0.10–0.84), 0.02 (IQR 0.004–0.09), respectively], and an increased interleukin (IL)-1β was associated with reduced species evenness (rs = − 0.33, p < 0.01) and increased pathogenic bacteria presence (rs = 0.28, p = 0.013). Untargeted 16s rRNA pathogen detection was limited by false positives, while the use of pathogen-specific relative abundance thresholds showed better diagnostic accuracy (AUROCC range 0.89–0.998). Conclusion: Patients with positive BALF culture had increased dysbiosis and genus dominance. An increased caspase-1-dependent IL-1b expression was associated with a reduced species evenness and increased pathogenic bacterial presence, providing a possible causal link between microbiome dysbiosis and lung injury development in VAP. However, measures of diversity were an unreliable predictor of culture positivity and 16s sequencing used agnostically could not usefully identify pathogens; this could be overcome if pathogen-specific relative abundance thresholds are used.
Ključne besede: Microbiome, Next-generation sequencing, Ventilator-associated pneumonia
Objavljeno v RUNG: 26.10.2022; Ogledov: 1027; Prenosov: 0
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