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Real-time multi-marker measurement of organic compounds in human breath: Towards fingerprinting breathIain R. White,
Kerry A Willis,
Christopher Whyte,
Rebecca Cordell,
Robert S Blake,
Andrew J Wardlaw, 2013, izvirni znanstveni članek
Opis: The prospects for exploiting proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) in medical diagnostics are illustrated through a series of case studies. Measurements of acetone levels in the breath of 68 healthy people are presented along with a longitudinal study of a single person over a period of 1 month. The median acetone concentration across the population was 484 ppbV with a geometric standard deviation (GSD) of 1.6, whilst the average GSD during the single subject longtitudinal study was 1.5. An additional case study is presented which highlights the potential of PTR-ToF-MS in pharmacokinetic studies, based upon the analysis of online breath samples of a person following the consumption of ethanol. PTR-ToF-MS comes into its own when information across a wide mass range is required, particularly when such information must be gathered in a short time during a breathing cycle. To illustrate this property, multicomponent breath analysis in a small study of cystic fibrosis patients is detailed, which provides tentative evidence that online PTR-ToF-MS analysis of tidal breath can distinguish between active infection and non-infected patients.
Ključne besede: Volatile Organic Compounds, breath, proton transfer reaction mass spectrometry, Cystic Fibrosis
Objavljeno v RUNG: 22.07.2019; Ogledov: 4218; Prenosov: 0
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