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Opis: Following the evidence for a hotspot in the arrival directions of the highest energy cosmic rays, the Telescope Array (TA) Experiment undertook the TAx4 upgrade to expand the area of our Surface Detectors (SD) by a factor of 4 and have added new Fluorescence Detector (FD) stations to view over the new SD arrays. Currently, TAx4 consists of 12 FDs and 257 SDs, of a planned 500, at a spacing of 2.08 km spread over two sites. TAx4 North (4 FDs), completed in 2018, views over the northern wing of the new SD, and TAx4 South (8 FDs), completed in 2019, views over the southern wing. Both FD sites are in routine observation, with data being taken remotely at the TAx4 South site. In this work, we will report on the performance of the TAx4 FD, showing data/MC comparisons. We will present a preliminary monocular energy spectrum for the TAx4 fluorescence detector and the progress of the hybrid analysis.
Ključne besede: Telescope Array, TAx4, indirect detection, fluorescence detection, ultra-high energy, cosmic rays, energy spectrum
Objavljeno v RUNG: 02.10.2023; Ogledov: 520; Prenosov: 4
Celotno besedilo (21,90 MB)
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Opis: The Telescope Array (TA) cosmic rays detector located in the State of Utah in the United States is the largest ultra high energy cosmic rays detector in the northern hemisphere. The Telescope Array Low Energy Extension (TALE) fluorescence detector (FD) was added to TA in order to lower the detector's energy threshold, and has succeeded in measuring the cosmic rays energy spectrum down to PeV energies, by making use of the direct Cherenkov light produced by air showers. In this contribution we present the results of a measurement of the cosmic-ray energy spectrum using TALE FD data collected over a period of ∼7 years. The data set used for this measurement is the same one used for the mass composition measurement that is presented, as a separate contribution, at this conference. The energy spectrum shows features consistent with the "knee" and the "second knee"; a similar result to our previous energy spectrum publication. This time using a different hadronic model, and different event selection criteria as explained in the text of this proceeding.
Ključne besede: Telescope Array, TALE, low energy extension, indirect detection, fluorescence detection, cerenkov light, ultra-high energy, cosmic rays, energy spectrum
Objavljeno v RUNG: 02.10.2023; Ogledov: 534; Prenosov: 6
Celotno besedilo (2,92 MB)
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Opis: The Pierre Auger Observatory is the most sensitive detector to primary photons with energies above ∼ 0.2 EeV. It measures extensive air showers using a hybrid technique that combines a fluorescence detector (FD) with a ground array of particle detectors (SD). The signatures of a photon-induced air shower are a larger atmospheric depth at the shower maximum (Xmax) and a steeper lateral distribution function, along with a lower number of muons with respect to the bulk of hadron-induced background. Using observables measured by the FD and SD, three photon searches in different energy bands are performed. In particular, between threshold energies of 1–10 EeV, a new analysis technique has been developed by combining the FD-based measurement of Xmax with the SD signal through a parameter related to its muon content, derived from the universality of the air showers. This technique has led to a better photon/hadron separation and, consequently, to a higher search sensitivity, resulting in a tighter upper limit than before. The outcome of this new analysis is presented here, along with previous results in the energy ranges below 1 EeV and above 10 EeV. From the data collected by the Pierre Auger Observatory in about 15 years of operation, the most stringent constraints on the fraction of photons in the cosmic flux are set over almost three decades in energy.
Ključne besede: Pierre Auger Observatory, indirect detection, fluorescence detection, surface array, hybrid detection, ultra-high energy, cosmic rays, photons
Objavljeno v RUNG: 29.09.2023; Ogledov: 730; Prenosov: 5
Celotno besedilo (1,12 MB)
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Opis: The Telescope Array (TA) is the largest cosmic ray observatory in the Northern Hemisphere. It is designed to measure the properties of cosmic rays over a wide range of energies. TA with it's low energy extension (TALE) observe cosmic-ray induced extensive air showers between 2 PeV and 100 EeV in hybrid mode using multiple instruments, including an array of scintillator detectors at the Earth's surface and telescopes to measure the fluorescence and Cerenkov light. The statistics at the highest energies is being enhanced with the ongoing construction of the TAx4 experiment which will quadruple the surface area of the detector. We review the present status of the experiments and most recent physics results on the cosmic ray anisotropy, chemical composition and energy spectrum. Notable highlights include a new feature in the energy spectrum at about 10^19.2 eV, and a new clustering of events in the direction of Perseus-Pisces supercluster above this energy. We also report on updated diffuse photon flux limits and new spectrum and composition results in the lower energy range from the TALE extension.
Ključne besede: Telescope Array, TALE, low energy extension, TAx4, indirect detection, hybrid detection, ground array, fluorescence detection, Cherenkov light, ultra-high energy, cosmic rays, energy spectrum, composition, anisotropy
Objavljeno v RUNG: 26.09.2023; Ogledov: 675; Prenosov: 5
Celotno besedilo (6,75 MB)
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Opis: Hypoxia refers to a condition where cells and tissues experience low, inadequate levels of O2. While healthy tissues are typically supplied with sufficient O2 (normoxia), cancerous tissues commonly face hypoxia due to the tumor’s extraordinarily high demand for oxygen. Various fluorescent small-molecule probes have been designed for selective detection of hypoxia in living cells, but few nanomaterials have been investigated for this type of bioimaging. Herein, we prepare a fluorescent covalent organic framework (COF) with β-ketoenamine linkages and post-synthetically modify it to conjugate hypoxia-sensitive nitroimidazole moieties into its pores (NI-COF). Stacks of sheets in NI-COF observed under electron microscopy were exfoliated by ultrasonication, and dynamic light scattering measurements confirmed particle size of less than 200 nm. Thus-prepared material exhibited good stability in physiological conditions and low cytotoxicity in in vitro experiments. NI-COF also showed useful fluorescence properties with an emission peak at 490 nm (λex = 420 nm) at both neutral and mildly acidic pH levels that are characteristic of tumor tissues. Encouraged by the favorable properties of the material, we incubated HeLa cells pre-treated in either hypoxic or normoxic conditions with NI-COF. Fluorescence microscopy images demonstrated that the material was preferentially taken up by hypoxic cells, which showed higher fluorescence signal in their interior than cells cultured under normoxia conditions. It is anticipated that this study will stimulate further developments of COFs for imaging various biological conditions.
Ključne besede: hypoxia, fluorescence, covalent organic frameworks, imaging, tumor cells
Objavljeno v RUNG: 19.09.2023; Ogledov: 794; Prenosov: 3
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