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Opis: The Auger Engineering Radio Array, an extension of the Pierre Auger Observatory with antennas in the MHz range, requires to monitor the atmospheric conditions, which have a large influence on the radio emission of air showers. In particular, amplified signals up to an order of magnitude have been detected as an affect of thunderstorms. For a more detailed investigation and more generally, for detecting thunderstorms, a new lightning detection system has been installed at the Pierre Auger Observatory in Argentina. In addition, an electric-field mill measures the field strength on ground level at the antenna array. With these measurements, data periods affected by thunderstorms can be identified. Additionally, a lightning trigger for the water-Cherenkov detectors was developed to read out individual stations when a lightning was detected nearby. With these data, a possible correlation between the formation of lightning and cosmic rays can be investigated even at low energies of about 10[sup]15 eV. The structure and functionality of the lightning detection are described and first data analyses are shown.
Najdeno v: ključnih besedah
Povzetek najdenega: ...The Auger Engineering Radio Array, an extension of the Pierre Auger...
Ključne besede: Pierre Auger Observatory, Auger Engineering Radio Array, atmospheric monitoring, lightning detectors
Objavljeno: 03.03.2016; Ogledov: 3610; Prenosov: 189
Polno besedilo (1,10 MB)

Opis: The Auger Engineering Radio Array (AERA) is an extension of the Pierre Auger Observatory. It is used to detect radio emission from extensive air showers in the 30 - 80 MHz frequency band. A focus of interest is the dependence of the radio emission on shower parameters such as the energy and the atmospheric depth of the shower maximum. After three phases of deployment, AERA now consists of 153 autonomous radio stations with different spacings, covering an area of about 17 km2. The size, station spacings, and geographic location at the same site or near other Auger extensions, are all targeted at cosmic ray energies above 10[sup]17 eV. The array allows us to explore different technical schemes to measure the radio emission as well as to cross calibrate our measurements with the established baseline detectors of the Auger Observatory. We present the most recent technological developments and selected experimental results obtained with AERA.
Najdeno v: ključnih besedah
Ključne besede: Pierre Auger Observatory, the Auger Engineering Radio Array (AERA), radio emission from extensive air showers, detector cross-calibration
Objavljeno: 03.03.2016; Ogledov: 3743; Prenosov: 184
Polno besedilo (2,79 MB)

Opis: Lecture relative to the biotechnological features of nanobodies
Najdeno v: ključnih besedah
Ključne besede: nanobodies, phage display, antibody engineering, panning
Objavljeno: 14.07.2016; Ogledov: 3588; Prenosov: 0
Polno besedilo (22,12 KB)

Najdeno v: ključnih besedah
Ključne besede: cosmic rays (CR), extensive air showers, EAS radio emission, Pierre Auger Observatory, Auger Engineering Radio Array, multi-hybrid CR detection
Objavljeno: 09.11.2016; Ogledov: 3642; Prenosov: 255
Polno besedilo (1,98 MB)

Opis: Antibodies are irreplaceable reagents in both research and clinical practice. Despite their relevance, the structural complexity of conventional mono- and polyclonal antibodies (IgG) has always been a limit for their engineering towards reagents optimized for specific applications, such as in vivo diagnostics and therapy. Furthermore, their isolation is time consuming, their production expensive, and their functionalization results often in heterogeneous macromolecule populations. These drawbacks promoted the search for both innovative antibody isolation strategies and alternative scaffolds. In vitro panning of pre-immune collections of recombinant antibody fragments allows for the simple and fast recovery of binders. Since they did not undergo somatic maturation, their affinity for targets can be insufficient but on the other hand they can be rapidly mutated by standard molecular biology techniques to generate second-generation antibodies among which to identify clones with improved characteristics. Both stochastic and rational methods have been proposed for the optimization process. Random mutagenesis followed by panning at stringent conditions has been successful used to select binders with improved physical characteristics. Rational methods try to identify in silico key residues involved in the regulation of specific antibody features, such as stability or binding affinity. The accuracy of these methods usually depends on the calculation resources. In this perspective, smaller molecules can be analyzed “better” than larger because of their restricted number of residues. Nanobodies small dimensions have been long appreciated since enable better tissue penetration, shorter clearance time, higher yields. Now it becomes evident that this characteristic makes them also optimal objects for modeling.
Najdeno v: ključnih besedah
Povzetek najdenega: ...has always been a limit for their engineering towards reagents optimized for specific applications, such...
Ključne besede: recombinant antibody modeling, nanobody engineering, molecular dynamics and docking
Objavljeno: 21.03.2018; Ogledov: 3585; Prenosov: 0
Polno besedilo (638,20 KB)