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1.
Exhaled volatile organic compounds and respiratory disease : recent progress and future outlook
Maria Chiara Magnano, Waqar Ahmed, Ran Wang, Martina Bergant Marušič, Stephen J. Fowler, Iain R. White, 2024, pregledni znanstveni članek

Opis: The theoretical basis of eVOCs as biomarkers for respiratory disease diagnosis is described, followed by a review of the potential biomarkers that have been proposed as targets from in vitro studies. The utility of these targets is then discussed based on comparison with results from clinical breath studies. The current status of breath research is summarised for various diseases, with emphasis placed on quantitative and targeted studies. Potential for bias highlights several important concepts related to standardization, including practices adopted for compound identification, correction for background inspired VOC levels and computation of mixing ratios. The compiled results underline the need for targeted studies across different analytical platforms to understand how sampling and analytical factors impact eVOC quantification. The impact of environmental VOCs as confounders in breath analysis is discussed alongside the potential that eVOCs have as biomarkers of air pollution exposure and future perspectives on clinical breath sampling are provided.
Ključne besede: breath analysis, disease diagnosis, exhaled volatile organic compounds, respiratory disease, environmental exposure analysis, breath analysis
Objavljeno v RUNG: 06.05.2024; Ogledov: 537; Prenosov: 6
.pdf Celotno besedilo (1,36 MB)
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2.
Tumour virus research
2021

Objavljeno v RUNG: 07.12.2023; Ogledov: 786; Prenosov: 2
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Contribution of APOBEC proteins 3A and 3B to the oncogenicity of HPV viruses
Nika Marija Lovšin, Fabio Lapenta, Urša Pečar Fonović, Katerina Jazbec, Elvira Maličev, Martina Bergant Marušič, 2023, objavljeni povzetek znanstvenega prispevka na konferenci

Ključne besede: APOBEC, HPV, oncogenicity, gene expression
Objavljeno v RUNG: 10.10.2023; Ogledov: 1110; Prenosov: 9
.pdf Celotno besedilo (7,73 MB)

5.
In vitro tumor hypoxia imaging with fluorescent covalent organic frameworks
Tina Skorjanc, Dinesh Shetty, Damjan Makuc, Gregor Mali, Martina Bergant Marušič, Matjaž Valant, 2023, objavljeni povzetek znanstvenega prispevka na konferenci

Opis: Hypoxia refers to a condition where cells and tissues experience low, inadequate levels of O2. While healthy tissues are typically supplied with sufficient O2 (normoxia), cancerous tissues commonly face hypoxia due to the tumor’s extraordinarily high demand for oxygen. Various fluorescent small-molecule probes have been designed for selective detection of hypoxia in living cells, but few nanomaterials have been investigated for this type of bioimaging. Herein, we prepare a fluorescent covalent organic framework (COF) with β-ketoenamine linkages and post-synthetically modify it to conjugate hypoxia-sensitive nitroimidazole moieties into its pores (NI-COF). Stacks of sheets in NI-COF observed under electron microscopy were exfoliated by ultrasonication, and dynamic light scattering measurements confirmed particle size of less than 200 nm. Thus-prepared material exhibited good stability in physiological conditions and low cytotoxicity in in vitro experiments. NI-COF also showed useful fluorescence properties with an emission peak at 490 nm (λex = 420 nm) at both neutral and mildly acidic pH levels that are characteristic of tumor tissues. Encouraged by the favorable properties of the material, we incubated HeLa cells pre-treated in either hypoxic or normoxic conditions with NI-COF. Fluorescence microscopy images demonstrated that the material was preferentially taken up by hypoxic cells, which showed higher fluorescence signal in their interior than cells cultured under normoxia conditions. It is anticipated that this study will stimulate further developments of COFs for imaging various biological conditions.
Ključne besede: hypoxia, fluorescence, covalent organic frameworks, imaging, tumor cells
Objavljeno v RUNG: 19.09.2023; Ogledov: 1151; Prenosov: 4
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6.
APOBEC proteins play an important role in human papillomavirus infection and oncogenesis
Martina Bergant Marušič, Fabio Lapenta, Nika Lovšin, 2023, objavljeni povzetek znanstvenega prispevka na konferenci (vabljeno predavanje)

Ključne besede: HPV, APOBEC, oncogenesis, infection
Objavljeno v RUNG: 20.07.2023; Ogledov: 1281; Prenosov: 7
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7.
Covalent organic frameworks for fluorescent imaging of hypoxia
Tina Škorjanc, Dinesh Shetty, Gregor Mali, Damjan Makuc, Martina Bergant Marušič, Matjaž Valant, 2023, objavljeni povzetek znanstvenega prispevka na konferenci

Ključne besede: hypoxia, covalent organic frameworks, imaging, fluorescence, post-synthetic modification
Objavljeno v RUNG: 06.06.2023; Ogledov: 1422; Prenosov: 2
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Correlation of APOBEC3A and APOBEC3B gene expression in HNSCC TCGA study
Fabio Lapenta, Christina Paparokidou, Martina Bergant Marušič, 2022, objavljeni povzetek znanstvenega prispevka na konferenci

Ključne besede: HPV, APOBEC proteins, gene expression, TCGA data
Objavljeno v RUNG: 29.11.2022; Ogledov: 1391; Prenosov: 44
.pdf Celotno besedilo (830,01 KB)
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